{
  "abstract": "Background Several coating strategies have been recently introduced to reduce thrombogenicity of flow diverters (FDs), while the P8RI coating focuses on stimulating endothelial cells for faster arterial healing. This study aims to evaluate early neointimal growth over the FD struts by comparing these two strategies in an animal model.Methods Bare Silk Vista (bare-SV), P8RI Silk Vista (P8RI-SV), and Pipeline Vantage with Shield technology (Shield-PV) were implanted in rabbits to treat elastase-induced aneurysms (n=6, 10, and 7, respectively) and in the aorta (n=6, 7, and 4, respectively). At 5 and 28 days, the devices were imaged with optical coherence tomography (OCT) to evaluate the stent-coverage ratio. Conventional histology and multiphoton microscopy were also performed.Results The aneurysm occlusion rate was similar in all three groups (P=0.577). On OCT images, the stent-coverage ratio on day 5 and day 28 (overall and at each location) was significantly higher with P8RI-SV compared with both bare-SV and Shield-PV (Kruskal-Wallis P<0.0001, Dunn post-test P<0.001 for both timepoints). Histological and multiphoton microscopy evaluations confirmed that the struts of P8RI-SV were covered by well-organized neointima expressing a high rate of collagen at the aneurysm neck and in the aorta, compatible with an advanced stage of tissue remodeling and stabilized neointima.Conclusion P8RI-SV demonstrated higher rates of neointimal formation covering the FD struts compared with bare-SV and Shield-PV at day 5 and day 28 in rabbits. These results confirm faster and improved arterial healing with P8RI coating; however, further studies are needed to evaluate the clinical benefits in patients.",
  "authors": [
    {
      "affiliations": [
        "EMIS Research Laboratory, CHU Limoges, Limoges, France",
        "NEURI Vascular Center, Hôpital Bicêtre NEURI, Le Kremlin-Bicêtre, France",
        "CNRS, XLIM, UMR 7252, University of Limoges, Limoges, France",
        "INSERM U1195, Paris-Saclay University Faculty of Medecine, Le Kremlin-Bicetre, France"
      ],
      "name": "Jonathan Cortese"
    },
    {
      "affiliations": [
        "EMIS Research Laboratory, CHU Limoges, Limoges, France"
      ],
      "name": "Géraud Forestier"
    },
    {
      "affiliations": [
        "EMIS Research Laboratory, CHU Limoges, Limoges, France",
        "CNRS, XLIM, UMR 7252, University of Limoges, Limoges, France"
      ],
      "name": "Sylvia M Bardet"
    },
    {
      "affiliations": [
        "EMIS Research Laboratory, CHU Limoges, Limoges, France",
        "Interventional neuroradiology, Centre Hospitalier Universitaire de Limoges, Limoges, France"
      ],
      "name": "Maxime Baudouin"
    },
    {
      "affiliations": [
        "EMIS Research Laboratory, CHU Limoges, Limoges, France",
        "Vascular Surgery, CHU Limoges, Limoges, France"
      ],
      "name": "Romain Chauvet"
    },
    {
      "affiliations": [
        "EMIS Research Laboratory, CHU Limoges, Limoges, France",
        "CNRS, XLIM, UMR 7252, University of Limoges, Limoges, France"
      ],
      "name": "Marie Laure Perrin"
    },
    {
      "affiliations": [
        "EMIS Research Laboratory, CHU Limoges, Limoges, France"
      ],
      "name": "Alexis Belgacem"
    },
    {
      "affiliations": [
        "EMIS Research Laboratory, CHU Limoges, Limoges, France",
        "Interventional Neuroradiology, Vall d’Hebron University Hospital, Barcelona, Spain",
        "Vall d’Hebron Research Institute, Barcelona, Spain"
      ],
      "name": "Francesco Diana"
    },
    {
      "affiliations": [
        "Pharmacy, University-hospital of Limoges, Limoges, France",
        "Inserm U1094, IRD U270, EpiMaCT - Epidémiologie des maladies chroniques en zone tropicale, Institut d’Epidémiologie et de Neurologie Tropicale, OmegaHealth, University of Limoges, Limoges, France"
      ],
      "name": "Voahirana Ratsimbazafy"
    },
    {
      "affiliations": [
        "Pharmacy, University-hospital of Limoges, Limoges, France",
        "Inserm U1094, IRD U270, EpiMaCT - Epidémiologie des maladies chroniques en zone tropicale, Institut d’Epidémiologie et de Neurologie Tropicale, OmegaHealth, University of Limoges, Limoges, France"
      ],
      "name": "Marine Coulomb"
    },
    {
      "affiliations": [
        "Pharmacy, University-hospital of Limoges, Limoges, France",
        "Inserm U1094, IRD U270, EpiMaCT - Epidémiologie des maladies chroniques en zone tropicale, Institut d’Epidémiologie et de Neurologie Tropicale, OmegaHealth, University of Limoges, Limoges, France"
      ],
      "name": "Margot D’Arrigo"
    },
    {
      "affiliations": [
        "Pharmacy, University-hospital of Limoges, Limoges, France",
        "Inserm U1094, IRD U270, EpiMaCT - Epidémiologie des maladies chroniques en zone tropicale, Institut d’Epidémiologie et de Neurologie Tropicale, OmegaHealth, University of Limoges, Limoges, France"
      ],
      "name": "Edouard Lefebvre"
    },
    {
      "affiliations": [
        "Pharmacy, University-hospital of Limoges, Limoges, France",
        "Inserm U1094, IRD U270, EpiMaCT - Epidémiologie des maladies chroniques en zone tropicale, Institut d’Epidémiologie et de Neurologie Tropicale, OmegaHealth, University of Limoges, Limoges, France"
      ],
      "name": "Sylvain Dulaurent"
    },
    {
      "affiliations": [
        "EMIS Research Laboratory, CHU Limoges, Limoges, France"
      ],
      "name": "Gregory Sasselina"
    },
    {
      "affiliations": [
        "EMIS Research Laboratory, CHU Limoges, Limoges, France"
      ],
      "name": "Daphnee Chandellier"
    },
    {
      "affiliations": [
        "EMIS Research Laboratory, CHU Limoges, Limoges, France"
      ],
      "name": "Jérémy Mounier"
    },
    {
      "affiliations": [
        "EMIS Research Laboratory, CHU Limoges, Limoges, France"
      ],
      "name": "Claude Couquet"
    },
    {
      "affiliations": [
        "EMIS Research Laboratory, CHU Limoges, Limoges, France"
      ],
      "name": "Caroline Croguennec"
    },
    {
      "affiliations": [
        "EMIS Research Laboratory, CHU Limoges, Limoges, France"
      ],
      "name": "Ludovic Micallef"
    },
    {
      "affiliations": [
        "EMIS Research Laboratory, CHU Limoges, Limoges, France"
      ],
      "name": "Aurélien Le Flahec"
    },
    {
      "affiliations": [
        "EMIS Research Laboratory, CHU Limoges, Limoges, France"
      ],
      "name": "Nicolas Dubois"
    },
    {
      "affiliations": [
        "NEURI Vascular Center, Hôpital Bicêtre NEURI, Le Kremlin-Bicêtre, France",
        "INSERM U1195, Paris-Saclay University Faculty of Medecine, Le Kremlin-Bicetre, France"
      ],
      "name": "Laurent Spelle"
    },
    {
      "affiliations": [
        "EMIS Research Laboratory, CHU Limoges, Limoges, France",
        "Interventional Neuroradiology, CHU Limoges, Limoges, France"
      ],
      "name": "Charbel Mounayer"
    },
    {
      "affiliations": [
        "CNRS, XLIM, UMR 7252, University of Limoges, Limoges, France",
        "Cell Biology, CHU Limoges, Limoges, France"
      ],
      "name": "Faraj Terro"
    },
    {
      "affiliations": [
        "EMIS Research Laboratory, CHU Limoges, Limoges, France",
        "CNRS, XLIM, UMR 7252, University of Limoges, Limoges, France",
        "Interventional neuroradiology, Centre Hospitalier Universitaire de Limoges, Limoges, France"
      ],
      "name": "Aymeric Rouchaud"
    }
  ],
  "title": "Comparative assessment of early neointimal formation: P8RI-coated Silk Vista versus Pipeline Vantage (Shield) in a rabbit model using optical coherence tomography",
  "uid": "8f46e097-1ac1-5065-8623-4580c7c6927a"
}