{
  "abstract": "Background Virtual simulation is increasingly used for aneurysm treatment. This study aimed to explore whether mechanical behavior biomarkers of the Woven EndoBridge (WEB) device as computed by Sim&Size simulation software were associated with aneurysmal occlusion status at follow-up.Methods Consecutive patients with aneurysms treated with WEB were retrospectively enrolled (January 2014 to December 2021). Aneurysms were included if three-dimensional digital subtraction angiography and follow-up imaging were available. Device apposition and compression within the aneurysm sac were retrospectively calculated by Sim&Size simulation software. Mean global and maximum compression, mid-device and neck compression, and the Spruce index of heterogeneity of deformation of the simulated device were calculated. A multivariate Lasso regression was performed.Results A total of 81 aneurysms in 80 patients (56 females; mean age 60±12 years) were analyzed. At a mean radiological follow-up of 3±2 years, 62 (77%) showed an adequate occlusion. Mean apposition in the inadequate and adequate occlusion group was 42.9±11% and 53.97±12%, respectively (P=0.002), mean global compression was 4.95±3% and 7.85±6% (P=0.035), respectively, and maximal compression was 13.44±6% and 20.73±11%, respectively (P=0.009). Compressions at mid-level and neck level were comparable between the two groups. The Spruce index was higher in the inadequate occlusion group (0.16±0.05 vs 0.20±0.05, P=0.005). Multivariate analysis showed that wall apposition, maximum compression and the Spruce index were independent prognosticators of aneurysm occlusion.Conclusions Wall apposition, maximum compression and the Spruce index computed by Sim&Size software predicted the likelihood of aneurysm occlusion at follow-up, after WEB treatment.",
  "authors": [
    {
      "affiliations": [
        "Neuroradiology department, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"
      ],
      "name": "Federico Cagnazzo"
    },
    {
      "affiliations": [
        "Sim&Cure, Montpellier, France"
      ],
      "name": "Alexis Atallah"
    },
    {
      "affiliations": [
        "Neuroradiology department, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"
      ],
      "name": "Liesjet E H van Dokkum"
    },
    {
      "affiliations": [
        "Neuroradiology, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"
      ],
      "name": "Carolina Capirossi"
    },
    {
      "affiliations": [
        "Neuroradiology, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"
      ],
      "name": "Gregory Gascou"
    },
    {
      "affiliations": [
        "Neuroradiology, Gui de Chauliac, University Hospital Centre Montpellier, Montpellier, France"
      ],
      "name": "Cyril Dargazanli"
    },
    {
      "affiliations": [
        "Neuroradiology, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"
      ],
      "name": "Pierre Henri Lefevre"
    },
    {
      "affiliations": [
        "Neuroradiology, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"
      ],
      "name": "Gianfranco Di Salle"
    },
    {
      "affiliations": [
        "Department of Diagnostics, Diagnostic and Interventional Neuroradiology, HUG, Geneve, Switzerland",
        "Brain Endovascular Therapeutics Research & Development Lab, Radiology and Medical Informatics, University of Geneva, Geneve, Switzerland"
      ],
      "name": "Paolo Machi"
    },
    {
      "affiliations": [
        "Neuroradiology, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"
      ],
      "name": "Francois-Louis Collemiche"
    },
    {
      "affiliations": [
        "Neuroradiology, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"
      ],
      "name": "Quentin Varnier"
    },
    {
      "affiliations": [
        "Neuroradiology, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"
      ],
      "name": "Thomas Checkouri"
    },
    {
      "affiliations": [
        "Sim&Cure, Montpellier, France"
      ],
      "name": "Christophe Chnafa"
    },
    {
      "affiliations": [
        "Sim&Cure, Montpellier, France"
      ],
      "name": "Amandine Rene"
    },
    {
      "affiliations": [
        "Neuroradiology, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"
      ],
      "name": "Răzvan Alexandru Radu"
    },
    {
      "affiliations": [
        "Neuroradiology, Gui de Chauliac, University Hospital Centre of Montpellier, Montpellier, France"
      ],
      "name": "Vincent Costalat"
    }
  ],
  "title": "Woven EndoBridge device apposition and compression using Sim&Size virtual simulation correlate with aneurysm occlusion status: a retrospective cohort study",
  "uid": "23e6dd3b-d390-5eb8-a902-51c0d29171c4"
}