{
  "abstract": "Background Large-bore aspiration catheters are integral to mechanical thrombectomy (MT) for large vessel occlusions (LVOs), offering potential for improved first pass success and faster recanalization.Objective To assess the clinical performance, efficacy, and safety profile of the Broadway 8 system as a primary aspiration device in MT of LVOs.Methods This is a multicenter observational study conducted across 8 US comprehensive stroke centers. Efficacy outcomes included first pass effect (FPE), defined as a single-pass modified Treatment In Cerebral Infarction (mTICI) score ≥2c, and successful reperfusion (final mTICI ≥2b). Safety outcomes included device-related complications, symptomatic intracranial hemorrhage (sICH), and inpatient mortality. Functional outcomes included modified Rankin Scale (mRS) at discharge and delta National Institutes of Health Stroke Scale (NIHSS) score. Logistic regression was used to assess predictors of thrombus access and intermediate catheter use.Results 49 patients were included. The Broadway 8 system reached the thrombus in 44 (89.8%). Median puncture-to-thrombus and puncture-to-reperfusion times were 11 min (IQR 9–18) and 20 min (14–31), respectively. FPE was achieved in 20 (40.8%). Successful reperfusion was achieved in 46/49 (93.8%), with 35 (71.4%) using Broadway 8. sICH occurred in 2 patients (4.1%). Median mRS at discharge was 3.0 (IQR 1.0–4.0); delta NIHSS was 8 (IQR 5–12). Regression analysis showed faster reperfusion when Broadway 8 was used without an intermediate catheter.Conclusion The Broadway 8 system appears to be a safe and effective frontline aspiration device, demonstrating a safety and efficacy profile comparable to other large-bore aspiration systems that incorporate delivery-assist technology.",
  "authors": [
    {
      "affiliations": [
        "HCA Florida Ocala Hospital, UCF College of Medicine, Ocala, Florida, USA"
      ],
      "name": "Rime Ezzeldin"
    },
    {
      "affiliations": [
        "Radiology, New York University Langone Medical Center, New York, New York, USA"
      ],
      "name": "Osman Mir"
    },
    {
      "affiliations": [
        "Emergency Medicine, HCA Houston, Kingwood, Texas, USA"
      ],
      "name": "Adam Delora"
    },
    {
      "affiliations": [
        "Department of Radiology, West Virginia University, Morgantown, West Virginia, USA"
      ],
      "name": "SoHyun Boo"
    },
    {
      "affiliations": [
        "Neurology, Neurosurgery and Radiology, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA"
      ],
      "name": "Santiago Ortega-Gutierrez"
    },
    {
      "affiliations": [
        "Department of Neurology, Emory University, Atlanta, Georgia, USA"
      ],
      "name": "Jaydevsinh Dolia"
    },
    {
      "affiliations": [
        "Neurology and Radiology, Emory University School of Medicine, Atlanta, Georgia, USA"
      ],
      "name": "Diogo C Haussen"
    },
    {
      "affiliations": [
        "Neurosurgery, Geisinger Health System, Wilkes-Barre, Pennsylvania, USA"
      ],
      "name": "Clemens Maria Schirmer"
    },
    {
      "affiliations": [
        "Neurosurgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"
      ],
      "name": "Fadi Alsaiegh"
    },
    {
      "affiliations": [
        "Neurosurgery, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA"
      ],
      "name": "Justin Mascitelli"
    },
    {
      "affiliations": [
        "Department of Neurology, University of Texas Rio Grande Valley, Harlingen, Texas, USA"
      ],
      "name": "Ameer E Hassan"
    },
    {
      "affiliations": [
        "Carondelet Neurological Institute, Carondelet Health Network, Tucson, Arizona, USA"
      ],
      "name": "Muhammad Waqas Khan"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, NYU Langone Health, New York, New York, USA"
      ],
      "name": "Jan-Karl Burkhardt"
    },
    {
      "affiliations": [
        "The University of Texas Medical Branch John Sealy School of Medicine, Galveston, Texas, USA"
      ],
      "name": "Omar Malik"
    },
    {
      "affiliations": [
        "West Virginia University, Morgantown, West Virginia, USA"
      ],
      "name": "Daniel Diehl"
    },
    {
      "affiliations": [
        "Neurosurgery, University of Iowa, Iowa City, Iowa, USA"
      ],
      "name": "Mario Zanaty"
    },
    {
      "affiliations": [
        "Geisinger Health, Danville, Pennsylvania, USA"
      ],
      "name": "Ahmed Aljuboori"
    },
    {
      "affiliations": [
        "Department of Neuroscience, Valley Baptist Medical Center, Harlingen, Texas, USA"
      ],
      "name": "Samantha Miller"
    },
    {
      "affiliations": [
        "University of Pennsylvania, Philadelphia, Pennsylvania, USA"
      ],
      "name": "Visish M Srinivasan"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA"
      ],
      "name": "Kyle Scott"
    },
    {
      "affiliations": [
        "HCA Houston Healthcare Kingwood, Kingwood, Texas, USA"
      ],
      "name": "Zuhair Ali"
    },
    {
      "affiliations": [
        "Department of Clinical Sciences, College of Medicine, University of Houston, Houston, Texas, USA",
        "Neuroendovascular surgery, HCA Houston, Houston, Texas, USA"
      ],
      "name": "Mohamad Ezzeldin"
    }
  ],
  "title": "Broadway 8 system: a multicenter early evaluation of safety, performance, and clinical outcomes in mechanical thrombectomy",
  "uid": "22db77e6-90bc-5897-b5dc-ada14e6caf9b"
}