{
  "abstract": "The New Zealand rabbit elastase-induced arterial aneurysm of the right common carotid artery remains a widely used model for assessing the effectiveness and safety of new neuroendovascular devices.1 This model offers a simple and reliable platform for pre-clinical in vivo investigations, crucial for comprehending the biological processes underlying aneurysm healing after endovascular treatment.2 Notably, the induced aneurysm exhibits morphological, hemodynamic, and histological characteristics similar to human intracranial aneurysms. The creation of the aneurysm is performed using open and endovascular techniques. Each step of the procedure requires a meticulous and controlled gesture to ensure reproducibility of the aneurysm and minimize animal misuse. In video 1 we present a step-by-step procedural guide for aneurysm creation and follow-up. We hope this resource will help in promoting this model and provide useful guidance for researchers in the field. Video 1Surgical procedure of creating elastase-induced aneurysms in rabbits. media110.1136/jnis-2024-021912.video016354210921112jnis2024021912media1",
  "authors": [
    {
      "affiliations": [
        "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA",
        "NEURI Neurointerventional Radiology, Bicêtre Hospital, Le Kremlin-Bicêtre, France",
        "INSERM U1195, Paris-Saclay University, Le Kremlin-Bicêtre, France"
      ],
      "name": "Jonathan Cortese"
    },
    {
      "affiliations": [
        "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA"
      ],
      "name": "Esref Alperen Bayraktar"
    },
    {
      "affiliations": [
        "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA"
      ],
      "name": "Alexander A Oliver"
    },
    {
      "affiliations": [
        "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA"
      ],
      "name": "Cem Bilgin"
    },
    {
      "affiliations": [
        "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA"
      ],
      "name": "Yong-Hong Ding"
    },
    {
      "affiliations": [
        "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA"
      ],
      "name": "Yasuhito Ueki"
    },
    {
      "affiliations": [
        "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA"
      ],
      "name": "Sarah Lortscher"
    },
    {
      "affiliations": [
        "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA"
      ],
      "name": "Waleed Brinjikji"
    },
    {
      "affiliations": [
        "Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA"
      ],
      "name": "Ramanathan Kadirvel"
    },
    {
      "affiliations": [
        "Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA"
      ],
      "name": "David F Kallmes"
    }
  ],
  "title": "Creating elastase aneurysms in rabbits: a video primer",
  "uid": "9ccfc908-06ed-5edd-9de2-180a83850ba4"
}