{
  "abstract": "Background The aim of this study is to assess the feasibility of identifying the hemodynamic status of intracranial atherosclerotic stenosis (ICAS) using angio-based fractional flow (FF) calculated from a single angiographic view, with wire-based FF as the reference standard.Method The study retrospectively recruited 100 ICAS patients who underwent pressure wire measurement and digital subtraction angiography. The AccuICAD software was used to calculate angio-based FF, with the wire-measured value serving as the reference standard for evaluating the accuracy, consistency, and diagnostic performance of angio-based FF.Results The mean±SD value of wire-based FF was 0.77±0.18, while the mean value of angio-based FF was 0.77±0.19. A good correlation between angio-based FF and wire-based FF was evident (r=0.90, P<0.001), with good agreement (mean difference 0.00±0.08). The diagnostic accuracy of angio-based FF and percent diameter stenosis (DS%) were 93.23% versus 72.18%, 91.73% versus 72.93%, and 89.47% versus 78.95% for predicted wire-based FF thresholds of 0.70, 0.75, and 0.80, respectively. The area under the curve (AUC) values for angio-based FF and DS% were 0.975 versus 0.822, 0.970 versus 0.814, and 0.943 versus 0.826 at the respective thresholds, respectively.Conclusion The FF calculated from a single angiographic view can be considered an effective tool for functional assessment of cerebral arterial stenosis.",
  "authors": [
    {
      "affiliations": [
        "ArteryFlow Technology Co Ltd, Hangzhou, China"
      ],
      "name": "Jianping Xiang"
    },
    {
      "affiliations": [
        "Neurovascular Center, Changhai Hospital, Naval Medical Uniervisty, Shanghai, China"
      ],
      "name": "Lei Zhang"
    },
    {
      "affiliations": [
        "ArteryFlow Technology Co Ltd, Hangzhou, China"
      ],
      "name": "Chenbin Rong"
    },
    {
      "affiliations": [
        "ArteryFlow Technology Co Ltd, Hangzhou, China"
      ],
      "name": "Rong Zou"
    },
    {
      "affiliations": [
        "ArteryFlow Technology Co Ltd, Hangzhou, China"
      ],
      "name": "Yumeng Hu"
    },
    {
      "affiliations": [
        "Neurovascular Center, Changhai Hospital, Naval Medical Uniervisty, Shanghai, China"
      ],
      "name": "Yongwei Zhang"
    },
    {
      "affiliations": [
        "Brain Center, Zhejiang Hospital, Hangzhou, China"
      ],
      "name": "Ming Wang"
    },
    {
      "affiliations": [
        "Dept. of Neuroradiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany"
      ],
      "name": "Jens Fiehler"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA"
      ],
      "name": "Adnan H Siddiqui"
    },
    {
      "affiliations": [
        "Department of Neurology, Chinese PLA General Hospital, Beijing, China"
      ],
      "name": "Jun Wang"
    },
    {
      "affiliations": [
        "Interventional Neuroradiology Center, Beijing Tiantan Hospital, Beijing, China"
      ],
      "name": "Zhongrong Miao"
    },
    {
      "affiliations": [
        "Neurovascular Center, Changhai Hospital, Naval Medical Uniervisty, Shanghai, China"
      ],
      "name": "Pengfei Yang"
    },
    {
      "affiliations": [
        "Brain Center, Zhejiang Hospital, Hangzhou, China"
      ],
      "name": "Shu Wan"
    },
    {
      "affiliations": [
        "Neurovascular Center, Changhai Hospital, Naval Medical Uniervisty, Shanghai, China"
      ],
      "name": "Jianmin Liu"
    }
  ],
  "title": "Diagnostic accuracy of hemodynamic assessment of intracranial atherosclerotic stenosis from a single angiographic view: a validation study",
  "uid": "937dcfc4-20ba-589a-ad9f-0c03609761f8"
}