{
  "abstract": "Background The incidence of thrombosis in patients with intracranial atherosclerotic stenosis (ICAS) remains unclear. Optical coherence tomography (OCT) has the potential to explore the vessel wall structure of posterior-circulation ICAS because of its relatively straight anatomical structure compared with that of the anterior cerebral arteries. This study aimed to determine the prevalence and characteristics of thrombosis in the posterior-circulation ICAS using OCT.Methods This prospective study was conducted on 135 patients with posterior-circulation arterial stenosis who underwent OCT. All patients were symptomatic and had a severely stenotic lesion (70–99%) in the vetebrobasilar artery. The enrolled patients were classified according to the presence of in situ thrombus as defined by OCT. Clinical data and OCT characteristics were compared.Results Eighty-two patients diagnosed with posterior-circulation ICAS were enrolled. In situ thrombi were identified in 34 patients. Clinically, patients with in situ thrombus were more prone to cerebral infarctions than transient ischemic attacks. The percentage area of stenosis in the non-thrombus group was significantly lower than that in the thrombus group. The thrombus burden, mean flow area, mean thrombus area, maximum lipid arc, and mean lumen area were significantly different among white, red, and mixed thrombi.Conclusions We achieved in vivo vessel wall structural analysis of posterior-circulation ICAS with the largest sample size. We also revealed the true incidence of in situ thrombosis and potential corresponding clinical events of posterior-circulation ICAS for the first time.",
  "authors": [
    {
      "affiliations": [
        "Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, People's Republic of China",
        "China International Neuroscience Institute (China-INI), Beijing, People's Republic of China"
      ],
      "name": "Ran Xu"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, People's Republic of China",
        "China International Neuroscience Institute (China-INI), Beijing, People's Republic of China"
      ],
      "name": "Bin Yang"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, People's Republic of China",
        "China International Neuroscience Institute (China-INI), Beijing, People's Republic of China"
      ],
      "name": "Tao Wang"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, People's Republic of China",
        "China International Neuroscience Institute (China-INI), Beijing, People's Republic of China"
      ],
      "name": "Xiao Zhang"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, People's Republic of China",
        "China International Neuroscience Institute (China-INI), Beijing, People's Republic of China"
      ],
      "name": "Tianhua Li"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, People's Republic of China",
        "China International Neuroscience Institute (China-INI), Beijing, People's Republic of China"
      ],
      "name": "Yao Feng"
    },
    {
      "affiliations": [
        "Department of Neurology, Loma Linda University Health, Loma Linda, California, USA"
      ],
      "name": "Xiaofan Guo"
    },
    {
      "affiliations": [
        "School of Public Health and Center for Statistical Science, Peking University, Beijing, People's Republic of China"
      ],
      "name": "Jinzhu Jia"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, People's Republic of China",
        "China International Neuroscience Institute (China-INI), Beijing, People's Republic of China"
      ],
      "name": "Yan Ma"
    },
    {
      "affiliations": [
        "Neuroendovascular Program, Massachusetts General Hospital, Boston, Massachusetts, USA",
        "Neuroradiology and Neurointervention, Brigham and Women's Hospital, Boston, Massachusetts, USA"
      ],
      "name": "Adam A Dmytriw"
    },
    {
      "affiliations": [
        "Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China"
      ],
      "name": "Haibo Jia"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, People's Republic of China",
        "China International Neuroscience Institute (China-INI), Beijing, People's Republic of China",
        "Department of Interventional Neuroradiology, Xuanwu Hospital Capital Medical University, Beijing, People's Republic of China",
        "Daepartment of Neurosurgery and Neurology, Jinan Hospital of Xuanwu Hospital, Shandong First Medical University, Jinan, People's Republic of China"
      ],
      "name": "Liqun Jiao"
    }
  ],
  "title": "Prevalence of intracerebral thrombus detected by optical coherence tomography in patients with posterior circulation stroke or transient ischemic attack",
  "uid": "0b8024ef-0b9b-5b1d-9e39-9f45769e6aec"
}