{
  "abstract": "Introduction The safety and efficacy of the middle meningeal artery embolization (MMAE) in patients with non-acute or chronic subdural hematoma (cSDH) has significant reporting within recent literature, however mainly in the form of observational data.Aim of Study Evaluation of MMAE for cSDH.Method We conducted a comperhensive review including all available randomized clinical trials (RCTs) that compared MMAE in addition to standard of care (SOC) versus SOC alone for cSDH. The primary outcome was the rate of recurrence and reoperation. Secondary outcomes included serious adverse events (SAE), mortality rate, independent ambulation (Modified Rankin Scale (mRS) score 0–3), and changes in hematoma characteristics at 90 days. The fixed-effect or random-effects model was used based on the significance of the heterogeneity (I2>50%, P<0.1).Results Findings showed significant superiority of MMAE over SOC in 90-day recurrence (RR=0.55, 95%CI= 0.36 – 0.83, P=0.0047), 180-day reoperation (RR=0.38, 95%CI= 0.26 – 0.56, P<0.001), mRS0–3 (RR=1.034, 95%CI= 1.0 – 1.07, P=0.0296), SAE (RR= 0.59, 95%CI= 0.38 – 0.94, P=0.025), and 90-day mortality (RR=0.29, 95%CI= 0.14 – 0.6, P=0.0008). Successful embolization and 30-day embolization-related complications occurred in 99.2% (95%CI= 94.54% – 100%) and 1.18% (95%CI= 0.39% – 2.31%) of patients, respectively. Additionally, these findings were confirmed by subgroup analyses on major and pilot RCTs, embolic agents comparison, and MMAE adjuvant to surgery versus surgery alone.Abstract A222 Figure 1Conclusion MMAE appears to be safe and effective in the management of cSDH with low recurrence and SAE rateConflict of Interest No",
  "authors": [
    {
      "affiliations": [
        "Gonabad University of Medical Sciences, Gonabad, Iran"
      ],
      "name": "Ali Mortezaei"
    },
    {
      "affiliations": [
        "Central Michigan University, Michigan, USA"
      ],
      "name": "Nadir Al-Saidi"
    },
    {
      "affiliations": [
        "Gonabad University of Medical Sciences, Gonabad, Iran"
      ],
      "name": "Kiana Yahyaei"
    },
    {
      "affiliations": [
        "University of Miami, Miami, USA"
      ],
      "name": "Ahmed Abdelsalam"
    },
    {
      "affiliations": [
        "University of Miami, Miami, USA"
      ],
      "name": "Luis Guada Delgado"
    },
    {
      "affiliations": [
        "University of Miami, Miami, USA"
      ],
      "name": "Joshua Hanna"
    },
    {
      "affiliations": [
        "University of Pennsylvania, Pennsylvania, USA"
      ],
      "name": "Redi Rahmani"
    },
    {
      "affiliations": [
        "University of Miami, Miami, USA"
      ],
      "name": "Adib Abla"
    },
    {
      "affiliations": [
        "University of Miami, Miami, USA"
      ],
      "name": "Robert Starke"
    }
  ],
  "title": "A222 Middle meningeal artery embolization versus standard of care for chronic subdural hematoma: meta-analysis of randomized controlled trials",
  "uid": "e5f54323-1888-51c1-98af-0b78574e7835"
}