{
  "abstract": "Introduction Thromboembolic complications following complex aneurysm treatments may be prevented by long-term administration of tirofiban. However, due to the potential risk of complications—particularly intraparenchymal hemorrhage—surgical aneurysm occlusion may be preferred in such cases.Aim of study In this retrospective, propensity score-matched cohort study, we investigated whether long-term administration of tirofiban is associated with an increased risk of intraparenchymal hemorrhage after subarachnoid hemorrhage (SAH).Method We included 99 patients who underwent interventional treatment for ruptured aneurysms between 2006 and 2024. Fifty-two patients were initially identified from our database who received tirofiban peri- and post-interventionally after endovascular treatment of ruptured complex aneurysms. The control group (n = 43) was selected using propensity score matching based on clinical and imaging morphological characteristics. Within the tirofiban group, further stratification was performed into short-term (≤7 days; n = 29) and long-term (>7 days; n = 18) tirofiban administration.Results All intracranial bleeding complications occurred in association with surgical procedures. No significant differences in intraparenchymal hemorrhage were observed between the control group and patients receiving tirofiban for ≤7 days (p = 0.3) or >7 days (p = 0.8). Surgery-associated subdural hematomas were rare (5%) and did not differ significantly between patients without tirofiban and those receiving tirofiban for ≤7 days (p = 0.8) or >7 days (p = 0.2).Conclusion Long-term administration of tirofiban for more than 7 days following treatment of ruptured aneurysms is not associated with bleeding complications after intracranial surgery in patients with ruptured intracranial aneurysms.Conflict of Interest No",
  "authors": [
    {
      "affiliations": [
        "Department of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, TUM Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany"
      ],
      "name": "Julian Schwarting"
    },
    {
      "affiliations": [
        "Department of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, TUM Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany"
      ],
      "name": "Michael Griessmair"
    },
    {
      "affiliations": [
        "Department of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, TUM Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany"
      ],
      "name": "Jannis Bodden"
    },
    {
      "affiliations": [
        "Department of Neurosurgery, School of Medicine and Health, TUM Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany"
      ],
      "name": "Maria Wostrack"
    },
    {
      "affiliations": [
        "Department of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, TUM Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany"
      ],
      "name": "Martin Renz"
    },
    {
      "affiliations": [
        "Department of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, TUM Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany"
      ],
      "name": "Jan S Kirschke"
    },
    {
      "affiliations": [
        "Department of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, TUM Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany"
      ],
      "name": "Tobias Boeckh-Behrens"
    }
  ],
  "title": "A251 Long-term tirofiban administration is not associated with increased surgical risks after treatment of ruptured aneurysms",
  "uid": "bd2309cb-3580-5330-aef5-4ce4a59e3dc6"
}