{
  "abstract": "Introduction Evolocumab decreases level of low-density lipoprotein cholesterol (LDL-C) and mitigate vascular events.Aim of Study This study aimed to assess the efficacy and adverse events of intensive lipid-lowering treatment including evolocumab and ezetimibe (triple therapy) after endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) secondary to large vessel occlusion (LVO).Method This is retrospective analysis of the cohorts of the 5 comprehensive stroke centers between January 2021 and December 2024. The study included consecutive patients who had AIS secondary to LVO underwent successful EVT. Patients were dichotomized into 2 groups: triple therapy including evolocumab (140 mg every 2 weeks) and high intensity statin alone (standard therapy) during 12 weeks. The effect of triple therapy over high intensity statin alone was assessed.Results Of 197 patients (mean age 70.8, men 63.5%), 55 received triple therapy. While baseline lipid profile was similar between the two groups, triple therapy group showed significantly lower mean cholesterol and TG level. Triple therapy group showed a lower discharge NIHSS (2.7 ± 2.2 vs. 5.5 ± 6.9, p <0.001) and percentage of patients with early neurologic deterioration (1.8% vs. 17.6%, p = 0.002). At the 3-month follow-up, there was a non-significant trend suggesting improved outcomes in the triple therapy group. Multivariable analysis indicated that triple therapy had a potential impact on early neurologic deterioration (aOR: 13.820 [1.453–131.471]).Conclusion Triple therapy in AIS patients undergoing EVT appeared to be safe and associated with better early neurological outcomes.Conflict of Interest No",
  "authors": [
    {
      "affiliations": [
        "Kyung Hee University College of Medicine, Seoul, South Korea"
      ],
      "name": "Ho Geol Woo"
    },
    {
      "affiliations": [
        "Inha University Hospital, Incheon, South Korea"
      ],
      "name": "Hee Kwon Park"
    }
  ],
  "title": "A140 Effect of standard versus triple lipid lowering therapy after endovascular thrombectomy on functional outcomes in large vessel occlusion stroke (STYLE study): a multicenter experience",
  "uid": "64e2b5c4-3265-5121-a5cc-5fcfc2b80635"
}