{
  "abstract": "Introduction The efficacy and safety of endovascular treatment (EVT) in large core strokes (LCS) have been recently demonstrated by six RCTs. However, data regarding the benefit of EVT in real-world settings is limited.Aim of Study To describe the experience of an Argentinian center in treating LCS outside the setting of clinical trials, focusing on safety and efficacy outcomes.Method Retrospective review of consecutive patients with anterior circulation LCS who received EVT within 24 hours of symptom onset at our center during 2015–2025 with a minimum follow up of 90 days. LCS was defined as stroke with an ASPECTS score of 0–5 or ischemic core volume ≥50 ml. Primary outcome was defined as modified Rankin Scale (mRS) score ≤3 and ≤2 at 90 days. Safety outcomes were 90-day mortality and symptomatic intracranial hemorrhage (sICH) <48 hours.Results 150 patients fulfilled inclusion criteria, median age 72 years (IQR 58–80), 82 (55%) men. Median NIHSS at admission was 18 (IQR 14–22). Median time from symptom onset to groin puncture was 8.0 (IQR 4.7–10.4) hours, with 17% of patients within 12–24 hours and 78% achieving TICI 2b-3. Median infarct core volume was 80 (IQR 44–127), and median ASPECTS score 4 (IQR 3–5), with 22% patients scoring 0–2. At 90 days, 31% achieved mRS ≤3, 21% mRS ≤2, mortality was 45% and sICH rate was 23%.Abstract A259 Table 1Conclusion This real-world study demonstrates that EVT for LCS within 24 hours of symptom onset are similar from clinical trials.Conflict of Interest No",
  "authors": [
    {
      "affiliations": [
        "Clinica Sagrada Familia-ENERI, Ciudad Autonoma de Buenos Aires, Argentina"
      ],
      "name": "Julieta Rosales"
    },
    {
      "affiliations": [
        "Clinica Sagrada Familia-ENERI, Ciudad Autonoma de Buenos Aires, Argentina"
      ],
      "name": "Juan Cirio"
    },
    {
      "affiliations": [
        "Clinica Sagrada Familia-ENERI, Ciudad Autonoma de Buenos Aires, Argentina"
      ],
      "name": "Matias Lopez"
    },
    {
      "affiliations": [
        "Clinica Sagrada Familia-ENERI, Ciudad Autonoma de Buenos Aires, Argentina"
      ],
      "name": "David Freire"
    },
    {
      "affiliations": [
        "Clinica Sagrada Familia-ENERI, Ciudad Autonoma de Buenos Aires, Argentina"
      ],
      "name": "Laura Caballero"
    },
    {
      "affiliations": [
        "Clinica Sagrada Familia-ENERI, Ciudad Autonoma de Buenos Aires, Argentina"
      ],
      "name": "Manuel Chasco"
    },
    {
      "affiliations": [
        "Clinica Sagrada Familia-ENERI, Ciudad Autonoma de Buenos Aires, Argentina"
      ],
      "name": "Nicolas Perez"
    },
    {
      "affiliations": [
        "Clinica Sagrada Familia-ENERI, Ciudad Autonoma de Buenos Aires, Argentina"
      ],
      "name": "Esteban Scrivano"
    },
    {
      "affiliations": [
        "Clinica Sagrada Familia-ENERI, Ciudad Autonoma de Buenos Aires, Argentina"
      ],
      "name": "Carlos Bleise"
    },
    {
      "affiliations": [
        "Clinica Sagrada Familia-ENERI, Ciudad Autonoma de Buenos Aires, Argentina"
      ],
      "name": "Pedro Nicolas Lylyk"
    },
    {
      "affiliations": [
        "Clinica Sagrada Familia-ENERI, Ciudad Autonoma de Buenos Aires, Argentina"
      ],
      "name": "Ivan Lylyk"
    },
    {
      "affiliations": [
        "Clinica Sagrada Familia-ENERI, Ciudad Autonoma de Buenos Aires, Argentina"
      ],
      "name": "Lylyk Pedro"
    }
  ],
  "title": "A259 Endovascular therapy in large core strokes, a real world experience",
  "uid": "41d69c26-a42b-54b8-ae0c-2c78eb36cf2e"
}