{
  "abstract": "Aspiration thrombectomy is an established method of clot removal in acute ischemic stroke. Recent advancements have resulted in the generation of superbore catheters (SBCs) (ID>0.88’). SBCs offer potential for better recanalization rates via enhanced control of blood pressure and flow during the procedure.Aim of Study We aimed to assess the benefit of SBCs in comparison to conventional guide catheters (CGCs) systems.Method Two distinct in vitro anatomical models were used. Two SBC (A&B) and two CGC (C&D) systems were evaluated. Two groups of thrombus analogues: cohesive and friable, were prepared with ovine blood to create an occlusion in the M1 MCA. Device tracking and clot retrieval performance were evaluated by two neurointerventionalist’s. Five replicates were completed per device. Physiological blood pressure and flow were simulated and monitored throughout the experiment at defined time points.Abstract A131 Figure 1Influence of location of the guide catheter on flow rate through the MCA with a 6Fr LBC in placed in M1. A: CEREGLIDE™ 92 & CEREGLIDE™ 71, B: Zoom/Trac Star LDP 088 & Zoom 071, C: NeuronMax & SOFIA, D: NeuronMax & RED68Results Placement of SBCs in the MCA resulted in significant reductionof blood pressure and flow in comparison to CGC systems (p<0.001). However, when the SBC could not reach the MCA, they displayed similar haemodynamic control to CGC systems. SBC systems had the highest rates of clot retrieval success for friable thrombi, due to the ability of the 6Fr catheter to achieve flow reversal (p<0.001). Cohesive clot retrieval was found to be more sensitive to clot interactions with the catheter tip. The Zoom SBC, which possesses a bevelled tip, displayed lower rates of retrieval success compared to the CEREGLIDE TM 092 SBC.Abstract A131 Figure 2Percentage (%) flow restored to the MCA following first pass aspiration with a 6Fr aspiration catheter. A: CEREGLIDE™ 92 & CEREGLIDE™ 71, B: Zoom/Trac Star LDP 088 & Zoom 071, C: NeuronMax & SOFIA, D: NeuronMax & RED68Conclusion SBCs offer local reduction blood pressure and flow during aspiration, increasing the likelihood of clot retrieval success.Conflict of Interest Yes Aoife Glynn and Ray McCarthy are employees of Johnson and Johnson Med Tech Neurovascular",
  "authors": [
    {
      "affiliations": [
        "Johnson and Johnson Med Tech Neurovascular, Galway, Ireland",
        "Trinity College Dublin, Dublin, Ireland"
      ],
      "name": "Aoife Glynn"
    },
    {
      "affiliations": [
        "Karolinska Institute, Sweden, Ireland"
      ],
      "name": "Tommy Andersson"
    },
    {
      "affiliations": [
        "Beaumont Hospital, Dublin, Ireland"
      ],
      "name": "Sarah Power"
    },
    {
      "affiliations": [
        "Trinity College Dublin, Dublin, Ireland",
        "Advanced Materials and Bioengineering Research Centre (AMBER), RCSI and TCD, Dublin, Ireland"
      ],
      "name": "Bruce Murphy"
    },
    {
      "affiliations": [
        "Trinity College Dublin, Dublin, Ireland",
        "Advanced Materials and Bioengineering Research Centre (AMBER), RCSI and TCD, Dublin, Ireland"
      ],
      "name": "Caitríona Lally"
    },
    {
      "affiliations": [
        "Johnson and Johnson Med Tech Neurovascular, Galway, Ireland"
      ],
      "name": "Ray McCarthy"
    }
  ],
  "title": "A131 Super bore catheter’s reduce local blood pressure and flow increasing the likelihood of clot retrieval successs",
  "uid": "0c9c8115-27d6-5268-99bf-280ba2817109"
}