{
  "abstract": "Introduction Women with systemic lupus erythematosus (SLE) have increased prevalence of precancer cervical squamous intraepithelial lesions (SIL). This study aimed to compare human papillomavirus (HPV) seroprevalence, cervical HPV-DNA detection and HPV-related cervical lesions between SLE and immunocompetent women.Methods In this cross-sectional study, women aged 18–45 years with SLE receiving immunosuppressive or disease-modifying antirheumatic drugs were compared with immunocompetent women, selected from the same hospital in Sao Paulo, Brazil. Eligible participants had no self-reported history of genital warts or any other HPV-related cervical, vaginal or vulvar lesions, nor received prior HPV vaccination. Cervical samples were tested for HPV-DNA using PapilloCheck and for SIL lesions by liquid-based cytology. A multiplex pseudovirion-based serology assay (PsV-Luminex) measured serum antibodies against eight of the HPV types targeted by non-valent (9vHPV) HPV vaccine.Results A total of 122 women with SLE and 132 immunocompetent women (mean age 34.3 and 32.5 years, respectively) were enrolled. Compared with immunocompetent women, SLE participants had higher prevalence of HPV-related cervical lesions (low-grade and high-grade SIL combined, 11.3% vs 2.4%, p=0.009), higher prevalence of at least one cervical HPV type (38.8% vs 20.2%, p=0.003), non-significantly higher prevalence of cervical high-risk HPV types (23.5% vs 14.9% p=0.286) and higher HPV seroprevalence to eight HPV types included in the 9vHPV vaccine (80.4% vs 59.7%, p=0.001).Conclusion Our findings underscore the importance of tailored cervical cancer screening and HPV vaccination of SLE women at young age.",
  "authors": [
    {
      "affiliations": [
        "Departamento de Infectologia e Medicina Tropical, Universidade de Sao Paulo, São Paulo, Brazil",
        "Centro de Referencia para Imunobiologicos Especiais, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil"
      ],
      "name": "Vanessa Infante"
    },
    {
      "affiliations": [
        "Centro de Referencia para Imunobiologicos Especiais, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil",
        "Departamento de Infectologia e Medicina Tropical, Universidade de Sao Paulo (FMUSP), São Paulo, Brazil"
      ],
      "name": "Karina Takesaki Miyaji"
    },
    {
      "affiliations": [
        "Centro de Referencia para Imunobiologicos Especiais, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil"
      ],
      "name": "Camila Cristina Rodrigues Martini"
    },
    {
      "affiliations": [
        "Centro de Referencia para Imunobiologicos Especiais, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil"
      ],
      "name": "Camila Picone"
    },
    {
      "affiliations": [
        "Rheumatology, Universidade de Sao Paulo Faculdade de Medicina, São Paulo, Brazil"
      ],
      "name": "Sandra G Pasoto"
    },
    {
      "affiliations": [
        "Laboratorio de Investigacao Medica - Virologia (LIM-52), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil"
      ],
      "name": "Jose Eduardo Levi"
    },
    {
      "affiliations": [
        "Laboratorio de Investigacao Medica - Virologia (LIM-52), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil"
      ],
      "name": "Ana Carolina Soares Oliveira"
    },
    {
      "affiliations": [
        "Centro de Referencia para Imunobiologicos Especiais, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil"
      ],
      "name": "Amanda Lara"
    },
    {
      "affiliations": [
        "Center for Cervical Cancer Elimination, Karolinska Institutet, Stockholm, Sweden"
      ],
      "name": "Hanna Kann"
    },
    {
      "affiliations": [
        "Center for Cervical Cancer Elimination, Karolinska Institutet, Stockholm, Sweden"
      ],
      "name": "Carina Eklund"
    },
    {
      "affiliations": [
        "Center for Cervical Cancer Elimination, Karolinska Institutet, Stockholm, Sweden"
      ],
      "name": "Joakim Dilner"
    },
    {
      "affiliations": [
        "Clinica de Ginecologia, FMUSP, São Paulo, Brazil"
      ],
      "name": "Cristina Paula Castanheira"
    },
    {
      "affiliations": [
        "Clinica de Ginecologia, FMUSP, São Paulo, Brazil"
      ],
      "name": "Maricy Tacla"
    },
    {
      "affiliations": [
        "Laboratorio de Investigacao Medica – Imunologia (LIM-48), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil"
      ],
      "name": "Paula Sato"
    },
    {
      "affiliations": [
        "Rheumatology, Universidade de Sao Paulo Faculdade de Medicina, São Paulo, Brazil"
      ],
      "name": "Eloisa Bonfá"
    },
    {
      "affiliations": [
        "Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK"
      ],
      "name": "Philippe Mayaud"
    },
    {
      "affiliations": [
        "Centro de Referencia para Imunobiologicos Especiais, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil",
        "Departamento de Infectologia e Medicina Tropical, Universidade de Sao Paulo (FMUSP), São Paulo, Brazil"
      ],
      "name": "Ana Mari Christovam Sartori"
    }
  ],
  "title": "Human papillomavirus (HPV) seroprevalence, cervical HPV prevalence and cervical lesions in systemic lupus erythematosus (SLE) and immunocompetent women",
  "uid": "a2f1e159-4845-5f20-97f4-8ee493156d13"
}