{
  "abstract": "Objectives Pulmonary diseases (PDs) in SLE are thought to be common and of clinical importance but can be difficult to diagnose. Prior studies report divergent estimates of the prevalence of PD in SLE ranging from 30% to 98%. Therefore, our primary objective was to determine the prevalence of PD in patients with SLE, through a population-based cross-sectional study. Our secondary objectives were to investigate in patients with SLE: (1) the prevalence of specific subtypes of PD, (2) pulmonary function and (3) associations between selected patient characteristics and presence of PD and subtypes of PD.Methods We invited adult patients with SLE who met the classification criteria and lived in Region Southern Denmark. Each participant underwent a clinical assessment, pulmonary function tests (PFTs) and a chest high-resolution CT scan (HRCT). Subsequently, participants were assessed and diagnosed according to the presence of PD and subtypes of PD at a multidisciplinary discussion.Results We found PDs were prevalent in 109 (59%) of the 185 included participants, among whom interstitial lung diseases were prevalent in 22 (12%), pleural diseases in 35 (19%) and airway diseases in 70 (38%). PD and subtypes of PD were associated with decreased pulmonary function, but the PFT measures showed a low combined sensitivity and specificity for detecting PD and subtypes of PD. We found no strong associations between selected patient characteristics and the presence of PD or subtypes of PD.Conclusion 59% of patients with SLE have PD, and PD was associated with decreased pulmonary function. Diagnosing PD in SLE remains challenging because clinical assessment and PFTs have limited utility. Accurate diagnosis often requires HRCT or other specialised investigations.Trial registration number NCT06087523.",
  "authors": [
    {
      "affiliations": [
        "Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark"
      ],
      "name": "Henrik Zachar Langkilde"
    },
    {
      "affiliations": [
        "Odense Respiratory Research Unit (ODIN), Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark",
        "South Danish Center for Interstitial Lung Diseases (SCILS) and Pulmo-Rheuma Frontline Center (PURE) Department of Respiratory Medicine, Odense Universitetshospital, Odense, Denmark"
      ],
      "name": "Jesper Rømhild Davidsen"
    },
    {
      "affiliations": [
        "Research Unit of Department of Radiology, University of Southern Denmark, Odense Universitetshospital, Odense, Denmark"
      ],
      "name": "Stefan Harders"
    },
    {
      "affiliations": [
        "Odense Respiratory Research Unit (ODIN), Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark"
      ],
      "name": "Stefan Luef"
    },
    {
      "affiliations": [
        "Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark"
      ],
      "name": "Susan Due Kay"
    },
    {
      "affiliations": [
        "Department of Rheumatology, Vejle Hospital, Vejle, Denmark"
      ],
      "name": "Tine Lottenburger"
    },
    {
      "affiliations": [
        "Department of Rheumatology, Vejle Hospital, Vejle, Denmark",
        "Department of Rheumatology, University Hospital of Southern Denmark, Esbjerg and Grindsted Hospital, Esbjerg, Denmark"
      ],
      "name": "Stavros Chrysidis"
    },
    {
      "affiliations": [
        "Danish Center for Expertise in Rheumatology, Danish Hospital for Rheumatic Diseases, Sønderborg, Denmark",
        "Institute for Regional Health Research, Southern Danish University, Sønderborg, Denmark"
      ],
      "name": "Karen Schreiber"
    },
    {
      "affiliations": [
        "Medicine Solna, Unit of Rheumatology, Karolinska Institutet/Karolinska University Hospital, Stockholm, Sweden"
      ],
      "name": "Elisabet Svenungsson"
    },
    {
      "affiliations": [
        "Systemic Lupus Erythematosus Patient Research Partner, Department of Rheumatology, Odense Universitetshospital, Odense, Denmark"
      ],
      "name": "Sille Fløjborg"
    },
    {
      "affiliations": [
        "Section for Biostatistics and Evidence-Based Research, Parker Instituttet, Copenhagen, Denmark"
      ],
      "name": "Robin Christensen"
    },
    {
      "affiliations": [
        "Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Odense, Denmark",
        "Department of Clinical Research, University of Southern Denmark Faculty of Health Sciences, Odense, Denmark"
      ],
      "name": "Anne Voss"
    }
  ],
  "title": "Pulmonary diseases in SLE: a population-based cross-sectional study",
  "uid": "9675416c-9a22-5052-8cfc-ea7955d88d6c"
}