{
  "abstract": "Objectives Patients (pts) with systemic lupus erythematosus (SLE) have a significantly increased risk of atherosclerotic cardiovascular disease (ASCVD). EULAR recommends comprehensive assessment and management of cardiovascular risk (CVR), following general population guidelines. Statin therapy plays a key role in reducing CVR and preventing ASCVD events. We aimed to determine the proportion of pts with SLE eligible for statin use for primary ASCVD prevention, based on American and European CVR guidelines.Methods This observational, cross-sectional study of GLADEL 2.0, a multi-ethnic Latin-American SLE cohort, analyzed demographics, comorbidities, medications, disease activity, and laboratory data. Statin eligibility was determined using the 2019 ACC/AHA and 2021 ESC guidelines. CVR was assessed using the ASCVD risk calculator from ACC/AHA, SCORE2, and PAHO risk scores. Both guidelines only consider pts >=40 years of age as candidates for CVR prevention with statins, due to eligibility dependence on CVR scores. Therefore, a comparative analysis was conducted between pts above and below this age threshold.Results Among 1083 pts, 394 (36.4%) were >=40 years of age ( table 1). ACC/AHA could only be calculated for 164 pts, PAHO for 351 pts, and SCORE2 for 181 pts. Most of these pts were categorized as having low CVR, regardless of the calculator used. 15 pts were indicated to receive statin therapy based on European guidelines; among these only 5 (33%) had a previous prescription for statin. Among 50 pts eligible for statins based on American guidelines, only 13 (26%) had been prescribed them. Inter-guideline agreement on statin eligibility was fair (Cohen’s Kappa=0.35; 95% CI: 0.15–0.55). Pts <40 years were more obese and had higher disease activity than those >=40 years (table 2).Abstract PO:03:076 Table 1Baseline clinical characteristics, disease activity, damage index, and treatmentsAbstract PO:03:076 Table 2Comparision of clinical characteristics based on their age groupConclusions Only a small percentage of pts were candidates for statin therapy, primarily due to the predominance of pts under age 40, where traditional CVR assessment tools are not applicable. Among eligible pts, statin prescribing rates remain low. The moderate agreement between differing guidelines highlights the inconsistency in risk assessment and management approaches for this population. Tailored strategies and more inclusive guidelines are needed to comprehensively evaluate and address CVR in younger pts with chronic inflammatory conditions like SLE.",
  "authors": [
    {
      "affiliations": [
        "Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina"
      ],
      "name": "Guillermo Pons-Estel"
    },
    {
      "affiliations": [
        "Centro Traumatológico Bariloche, Río Negro, Argentina"
      ],
      "name": "Carolina A Isnardi"
    },
    {
      "affiliations": [
        "Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico"
      ],
      "name": "Ileana Cecilia Reynosa-Silva"
    },
    {
      "affiliations": [
        "Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico"
      ],
      "name": "Iris Jazmin Colunga-Pedraza"
    },
    {
      "affiliations": [
        "Universidad Nacional de Rosario, Rosario, Argentina"
      ],
      "name": "Guillermina Harvey"
    },
    {
      "affiliations": [
        "Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico"
      ],
      "name": "Dionicio Ángel Galarza-Delgado"
    },
    {
      "affiliations": [
        "Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico"
      ],
      "name": "José Ramón Azpiri-López"
    },
    {
      "affiliations": [
        "Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico"
      ],
      "name": "Fernanda Massiel García García"
    },
    {
      "affiliations": [
        "Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico"
      ],
      "name": "Oscar Azael Garza Flores"
    },
    {
      "affiliations": [
        "Hospital Italiano de Buenos Aires, Argentina"
      ],
      "name": "Marina Scolnik"
    },
    {
      "affiliations": [
        "Hospital Italiano de Córdoba, Córdoba, Argentina"
      ],
      "name": "Gisela Subils"
    },
    {
      "affiliations": [
        "Servicio de Reumatología Hospital Córdoba y Sanatorio Allende, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina"
      ],
      "name": "Cintia Otaduy"
    },
    {
      "affiliations": [
        "Hospital Privado Centro Médico de Córdoba",
        "Córdoba, Argentina"
      ],
      "name": "Verónica Saurit"
    },
    {
      "affiliations": [
        "Hospital San Martin de La Plata, La Plata, Argentina"
      ],
      "name": "Valeria Arturi"
    },
    {
      "affiliations": [
        "Sanatorio Británico",
        "Rosario, Argentina"
      ],
      "name": "Leonel Berbotto"
    },
    {
      "affiliations": [
        "Hospital Ángel C. Padilla, Tucumán, Argentina"
      ],
      "name": "Luciana Gonzalez Lucero"
    },
    {
      "affiliations": [
        "Hospital J.M Ramos Mejía, Buenos Aires, Argentina"
      ],
      "name": "Melissa Brenda Serna Góngora"
    },
    {
      "affiliations": [
        "Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires",
        "Buenos Aires, Argentina"
      ],
      "name": "María De Los Angéles Gargiulo"
    },
    {
      "affiliations": [
        "CEMIC Centro de Educación Médica e Investigaciones Clínicas ‘‘Norberto Quirno,’’ Buenos Aires, Argentina"
      ],
      "name": "Cecilia Nora Pisoni"
    },
    {
      "affiliations": [
        "Hospital Señor del Milagro Salta, Salta, Argentina"
      ],
      "name": "Maria Elena Crespo"
    },
    {
      "affiliations": [
        "Hospital General de Agudos Dr. Juan A. Fernández, Buenos Aires, Argentina"
      ],
      "name": "Mónica Sánchez Guamán"
    },
    {
      "affiliations": [
        "Hospital das Clinicas da Universidade Federal de Goias, Goiania, Brazil"
      ],
      "name": "Vitalina De Souza Barbosa"
    },
    {
      "affiliations": [
        "Hospital de Clínicas de Porto Alegre, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil"
      ],
      "name": "Andrese Aline Gasparin"
    },
    {
      "affiliations": [
        "Universidad Federal de Pernambuco, Recife, Brazil"
      ],
      "name": "Henrique Ataide Mariz"
    },
    {
      "affiliations": [
        "Hospital Universitário Pedro Ernesto – Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil"
      ],
      "name": "Francinne Machado Ribeiro"
    },
    {
      "affiliations": [
        "Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil"
      ],
      "name": "Eduardo F Borba"
    },
    {
      "affiliations": [
        "Escola Paulista de Medicina/Universidade federal de São Paulo (EPM/Unifesp), São Paulo, Brazil"
      ],
      "name": "Edgard Torres Dos Reis-Neto"
    },
    {
      "affiliations": [
        "Hospital del Salvador Santiago de Chile, Santiago, Chile"
      ],
      "name": "Iris Guerra Herrera"
    },
    {
      "affiliations": [
        "Facultad de medicina, Universidad San Sebastián, Santiago, Chile"
      ],
      "name": "Loreto Massardo"
    },
    {
      "affiliations": [
        "Clínica de la Costa y Universidad Simón Bolívar Barranquilla, Barranquilla, Colombia"
      ],
      "name": "Gustavo Aroca Martínez"
    },
    {
      "affiliations": [
        "Fundación Valle del Lili, Universidad Icesi, Cali, Colombia"
      ],
      "name": "Carlos A Cañas"
    },
    {
      "affiliations": [
        "Facultad de Medicina, Universidad Nacional de Colombia",
        "Servicio de reumatología, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, Colombia",
        "Hospital Universitario Nacional de Colombia"
      ],
      "name": "Gerardo Quintana-Lopez"
    },
    {
      "affiliations": [
        "Centro de Referencia en Osteoporosis and Reumatología, Pontificia Universidad Javeriana de Cali, Cali, Colombia"
      ],
      "name": "Carlos Enrique Toro Gutiérrez"
    },
    {
      "affiliations": [
        "Universidad de Especialidades Espíritu Santo, Guayaquil, Ecuador"
      ],
      "name": "Mario Javier Moreno Alvarez"
    },
    {
      "affiliations": [
        "División de Investigación en Salud, Hospital de Especialidades Dr. Antonio Fraga Mouret, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico"
      ],
      "name": "Miguel Ángel Saavedra"
    },
    {
      "affiliations": [
        "Hospital de Especialidades del Centro Médico Nacional SXXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico"
      ],
      "name": "Margarita Portela Hernández"
    },
    {
      "affiliations": [
        "Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico"
      ],
      "name": "Hilda Fragoso-Loyo"
    },
    {
      "affiliations": [
        "Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico"
      ],
      "name": "Luis M Amezcua-Guerra"
    },
    {
      "affiliations": [
        "Centro de Estudios de Investigación Básica y Clínica, S.C., Guadalajara, Mexico"
      ],
      "name": "Ignacio García De La Torre"
    },
    {
      "affiliations": [
        "Facultad de Medicina de la Universidad Autónoma de San Luis Potosí y Hospital Central Dr. Ignacio Morones Prieto, San Luis Potosí, Mexico"
      ],
      "name": "Jorge Isaac Velasco Santos"
    },
    {
      "affiliations": [
        "Hospital Universitario Dr. José Eleuterio Gonzalez, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México"
      ],
      "name": "Jorge A Esquivel Valerio"
    },
    {
      "affiliations": [
        "Facultad de Ciencias Medicas, Universidad Nacional de Asunción, San Lorenzo, Paraguay"
      ],
      "name": "Jhonatan Losanto"
    },
    {
      "affiliations": [
        "Hospital Nacional Edgardo Rebagliati Martins-EsSalud, Lima, Peru"
      ],
      "name": "Magaly Alva Linares"
    },
    {
      "affiliations": [
        "Grupo Peruano de Estudio de Enfermedades Autoinmunes Sistémicas, Universidad Científica del Sur, Lima, Peru",
        "Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Peru"
      ],
      "name": "Manuel F Ugarte-Gil"
    },
    {
      "affiliations": [
        "Hospital Nacional Cayetano Heredia, Universidad Peruana Cayetano Heredia, San Martín de Porres, Peru"
      ],
      "name": "Katiuzka Zuñiga Corrales"
    },
    {
      "affiliations": [
        "Hospital Docente Padre Billini, Santo Domingo, Dominican Republic"
      ],
      "name": "Roberto Muñoz Louis"
    },
    {
      "affiliations": [
        "Hospital de Clínicas, Facultad de Medicina, UDELAR, Montevideo, Uruguay"
      ],
      "name": "Carina Pizzarossa"
    },
    {
      "affiliations": [
        "Facultad de Medicina – Universidad de la República, Montevideo, Uruguay"
      ],
      "name": "Gonzalo Silveira"
    },
    {
      "affiliations": [
        "Johnson and Johnson, Horsham, PA, USA"
      ],
      "name": "Federico Zazzetti"
    },
    {
      "affiliations": [
        "Johnson and Johnson, Springhouse, PA, USA"
      ],
      "name": "Ashley Orillion"
    },
    {
      "affiliations": [
        "Sede de Investigación Universitaria (SIU), Universidad de Antioquia (UDEA), Medellín, Colombia"
      ],
      "name": "Gloria Vásquez"
    },
    {
      "affiliations": [
        "Centro Traumatológico Bariloche, Río Negro, Argentina",
        "Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico",
        "Universidad Nacional de Rosario, Rosario, Argentina",
        "Hospital Italiano de Buenos Aires, Argentina",
        "Hospital Italiano de Córdoba, Córdoba, Argentina",
        "Servicio de Reumatología Hospital Córdoba y Sanatorio Allende, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina",
        "Hospital Privado Centro Médico de Córdoba",
        "Córdoba, Argentina",
        "Hospital San Martin de La Plata, La Plata, Argentina",
        "Sanatorio Británico",
        "Rosario, Argentina",
        "Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina",
        "Hospital Ángel C. Padilla, Tucumán, Argentina",
        "Hospital J.M Ramos Mejía, Buenos Aires, Argentina",
        "Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires",
        "Buenos Aires, Argentina",
        "CEMIC Centro de Educación Médica e Investigaciones Clínicas ‘‘Norberto Quirno,’’ Buenos Aires, Argentina",
        "Hospital Señor del Milagro Salta, Salta, Argentina",
        "Hospital General de Agudos Dr. Juan A. Fernández, Buenos Aires, Argentina",
        "Hospital das Clinicas da Universidade Federal de Goias, Goiania, Brazil",
        "Hospital de Clínicas de Porto Alegre, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil",
        "Universidad Federal de Pernambuco, Recife, Brazil",
        "Hospital Universitário Pedro Ernesto – Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil",
        "Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil",
        "Escola Paulista de Medicina/Universidade federal de São Paulo (EPM/Unifesp), São Paulo, Brazil",
        "Hospital del Salvador Santiago de Chile, Santiago, Chile",
        "Facultad de medicina, Universidad San Sebastián, Santiago, Chile",
        "Clínica de la Costa y Universidad Simón Bolívar Barranquilla, Barranquilla, Colombia",
        "Fundación Valle del Lili, Universidad Icesi, Cali, Colombia",
        "Facultad de Medicina, Universidad Nacional de Colombia",
        "Servicio de reumatología, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, Colombia",
        "Hospital Universitario Nacional de Colombia",
        "Centro de Referencia en Osteoporosis and Reumatología, Pontificia Universidad Javeriana de Cali, Cali, Colombia",
        "Universidad de Especialidades Espíritu Santo, Guayaquil, Ecuador",
        "División de Investigación en Salud, Hospital de Especialidades Dr. Antonio Fraga Mouret, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico",
        "Hospital de Especialidades del Centro Médico Nacional SXXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico",
        "Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico",
        "Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico",
        "Centro de Estudios de Investigación Básica y Clínica, S.C., Guadalajara, Mexico",
        "Facultad de Medicina de la Universidad Autónoma de San Luis Potosí y Hospital Central Dr. Ignacio Morones Prieto, San Luis Potosí, Mexico",
        "Hospital Universitario Dr. José Eleuterio Gonzalez, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México",
        "Facultad de Ciencias Medicas, Universidad Nacional de Asunción, San Lorenzo, Paraguay",
        "Hospital Nacional Edgardo Rebagliati Martins-EsSalud, Lima, Peru",
        "Grupo Peruano de Estudio de Enfermedades Autoinmunes Sistémicas, Universidad Científica del Sur, Lima, Peru",
        "Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Peru",
        "Hospital Nacional Cayetano Heredia, Universidad Peruana Cayetano Heredia, San Martín de Porres, Peru",
        "Hospital Docente Padre Billini, Santo Domingo, Dominican Republic",
        "Hospital de Clínicas, Facultad de Medicina, UDELAR, Montevideo, Uruguay",
        "Facultad de Medicina – Universidad de la República, Montevideo, Uruguay",
        "Johnson and Johnson, Horsham, PA, USA",
        "Johnson and Johnson, Springhouse, PA, USA",
        "Sede de Investigación Universitaria (SIU), Universidad de Antioquia (UDEA), Medellín, Colombia"
      ],
      "name": "On Behalf of Grupo Latino Americano De Estudio De Lupus (Gladel) Study Group of Panlar"
    }
  ],
  "title": "PO:03:076 Systemic lupus erythematosus and statins in GLADEL 2.0: are cardiovascular risk prevention guidelines being followed?",
  "uid": "d6b73116-0078-508e-9fd2-372d75d5691c"
}