{
  "abstract": "Objectives A significant proportion of SLE patients experience poor sleep, often linked to stress, anxiety, and depression. This study aimed to assess sleep disorders, stress, and depression in a SLE cohort and examine their relationship with disease activity and serological markers.Methods We performed a prospective observational study in adults diagnosed with SLE who completed four validated questionnaires: PSQI (sleep quality), PSS (stress), PHQ-9 (depression), and ESS (daytime sleepiness). Disease activity was assessed using SLEDAI, and serum autoantibodies and cytokines were measured by ELISA.Results A total of 61 patients remained in the final analysis, with a mean age of 50.36 ± 15.52 years and SLEDAI scores ranging from 0 to 12. Poor sleep quality (PSQI > 5) was reported in 35 patients (57.4%), moderate-to-high stress in 39 (63.9%), and moderate-to-severe or severe depression in 23 (37.7%). Poor sleepers had significantly higher depression scores (p < 0.001), but sleep quality, depression, and stress were not associated with disease activity.Nighttime pain was significantly linked to nightmares (p = 0.007), interrupted sleep (p = 0.001), shorter sleep duration (p = 0.025), and overall poor sleep quality (p = 0.033), as well as reduced motivation (p = 0.001) and increased daytime dysfunction (p < 0.001). Severe depression was associated with the poorest sleep quality (p = 0.001). Depression scores correlated with age (p = 0.03) and pain (p = 0.001), while stress correlated with difficulty falling asleep (p = 0.019) and poor sleep quality (p = 0.004). Professional activity showed no significant association with stress levels or sleep quality.No significant associations were found between stress, depression, or sleep quality and professional activity, inflammatory markers (ESR, CRP), ANA, anti-dsDNA, antiphospholipid antibodies, SSA, SSB, C3, C4, IL-6, or TNF. However, SLEDAI scores correlated with IL-6 levels (p = 0.002). No notable associations were observed between medication and sleep, stress, or depression.Conclusions Sleep disturbances are frequent in SLE patients, mainly associated with nighttime pain, stress, and depression. Comprehensive management should address SLE manifestations and mental health, as early intervention on these factors may improve patients’ well-being and quality of life.",
  "authors": [
    {
      "affiliations": [
        "Grigore T. Popa University of Medicine and Pharmacy, Rheumatology, Iasi, Romania, Iasi, Romania"
      ],
      "name": "Patricia Richter"
    },
    {
      "affiliations": [
        "Grigore T. Popa University of Medicine and Pharmacy, Rheumatology, Iasi, Romania, Iasi, Romania",
        "Clinical Rehabilitation Hospital, Iasi, Romania, Iasi, Romania"
      ],
      "name": "Maria-Alexandra Burlui"
    },
    {
      "affiliations": [
        "Grigore T. Popa University of Medicine and Pharmacy, Rheumatology, Iasi, Romania, Iasi, Romania",
        "Clinical Rehabilitation Hospital, Iasi, Romania, Iasi, Romania"
      ],
      "name": "Elena Rezus"
    }
  ],
  "title": "PO:02:037 Depression, stress, and sleep quality in a systemic lupus erythematosus cohort: a prospective observational study",
  "uid": "b87b61c0-685f-572f-989d-375defb1094a"
}