{
  "abstract": "Objectives SMILES is a multicenter Spanish endeavor focused on a comprehensive molecular characterization of a cohort of lupus patients using transcriptomic, single cell sequencing and microbiome analysis. In this report we used baseline clinical data about diet habits to analyze potential associations with quality of life (QoL), disease activity and accrued damage.Methods Forty-one Rheumatology departments across Spain participated. We enrolled adults (>=18 years) fulfilling 1997 or 2019 ACR classification criteria for SLE. Evaluation included: medical record review, clinical assessment, blood, urine, fecal and cutaneous microbioma samples and cutaneous biopsies. SLEDAI 2K and BILAG indices for activity evaluation and SLICC disease index (SDI) for damage were used. An ad hoc diet habits questionnaire was used to assess this item with questions about the frequency of consuming fish, meat, legumes, bread, eggs, pasta, sweets and cold cuts using four-option responses about of the days of consumption per week (0, 1-2, 3-5 and 6-7). Additionally, other variable, pro-inflammatory diet (PID), was created for those patients with top consumption of sweets and cold cuts. QoL was measured with the LupusQoL across eight domains: physical health, pain, planning, intimate relationships, burden to others, emotional health, body image, and fatigue. Linear regression models were used in theses analyses setting a p value =<0.05 as statistically significant.Results 220 patients (90% women; mean age 45.8 ± 12.6 years; mean disease duration 12.0 ± 9.8 years) were included. PID was not associated with any QoL domain, clinical activity or damage. Moreover, the individual analysis of the different types of food did not give any relevant association, with the exception of egg consumption which showed worse results in the following QoL domains: body, burden, emotional, fatigue, pain and physical (p =<0.05), fish and legumes consumption associated with pain QoL domain and higher SLEDAI (p =<0.05) and diary consumption associated with fatigue (p= 0.02).Conclusions Overall, no relevant associations were found between diet habits and QoL, clinical activity and damage. The worse outcomes observed with greater intake of eggs and with fish, legumes and diary consumptions have not clear explanations and require further investigations.",
  "authors": [
    {
      "affiliations": [
        "Hospital Universitario Araba, Rheumatology, Vitoria, Spain"
      ],
      "name": "Jaime Calvo-Alén"
    },
    {
      "affiliations": [
        "Hospital Universitario de Jerez de la Frontera, Rheumatology, Cádiz, Spain"
      ],
      "name": "Miriam Gandia-Martínez"
    },
    {
      "affiliations": [
        "Hospital Universitario de Jerez de la Frontera, Rheumatology, Cádiz, Spain"
      ],
      "name": "Raúl Menor-Almagro"
    },
    {
      "affiliations": [
        "Complejo Hospitalario Universitario de A Coruña, Rheumatology, A Coruña, Spain"
      ],
      "name": "Mercedes Freire-González"
    },
    {
      "affiliations": [
        "Complejo Hospitalario Universitario de A Coruña, Rheumatology, A Coruña, Spain"
      ],
      "name": "Guillermo González-Arribas"
    },
    {
      "affiliations": [
        "Hospital Universitari Vall d´Hebron, Rheumatoloy, Barcelona, Spain",
        "Vall d´Hebron Hospital Research Institute, Lupus-Rheumatology, Barcelona, Spain"
      ],
      "name": "Josefina Cortés-Hernández"
    },
    {
      "affiliations": [
        "Vall d´Hebron Hospital Research Institute, Lupus-Rheumatology, Barcelona, Spain"
      ],
      "name": "María Royo-López"
    },
    {
      "affiliations": [
        "Hospital Universitario de Canarias, Rheumatology, Tenerife, Spain"
      ],
      "name": "María García-González"
    },
    {
      "affiliations": [
        "Hospital Universitario de Canarias, Rheumatology, Tenerife, Spain"
      ],
      "name": "Marta Hernández-Díaz"
    },
    {
      "affiliations": [
        "Hospital Universitari Parc Taulí, Rheumatology, Sabadell, Spain"
      ],
      "name": "Silvia García-Cirera"
    },
    {
      "affiliations": [
        "Hospital Universitari Parc Taulí, Rheumatology, Sabadell, Spain"
      ],
      "name": "Vera Ortiz-Santamaría"
    },
    {
      "affiliations": [
        "Hospital Universitari Son Llàtzer, Rheumatology, Palma, Spain"
      ],
      "name": "Regina Faré-García"
    },
    {
      "affiliations": [
        "Hospital Universitari Son Llàtzer, Dermatology, Palma, Spain"
      ],
      "name": "Ignacio Torné-Gutiérrez"
    },
    {
      "affiliations": [
        "Hospital Universitario Araba, Rheumatology, Vitoria, Spain"
      ],
      "name": "Juan R De Dios"
    },
    {
      "affiliations": [
        "Hospital Universitario Araba, Rheumatology, Vitoria, Spain"
      ],
      "name": "Carmen García-Gómez"
    },
    {
      "affiliations": [
        "Hospital Universitario Araba, Endocrinology and Metabolism, Vitoria, Spain"
      ],
      "name": "María Ángeles Vicente-Vicente"
    },
    {
      "affiliations": [
        "Hospital Universitario Ramón y Cajal, Rheumatology, Madrid, Spain"
      ],
      "name": "Sandra Garrote-Corral"
    },
    {
      "affiliations": [
        "Hospital Universitario Ramón y Cajal, Dermatology, Madrid, Spain"
      ],
      "name": "Elena De Las Heras-Alonso"
    },
    {
      "affiliations": [
        "Hospital Universitari de Bellvitge, Rheumatology, Hospitalet de Llobregat, Spain"
      ],
      "name": "Javier Narváez-García"
    },
    {
      "affiliations": [
        "Hospital Universitari de Bellvitge, Rheumatology, Hospitalet de Llobregat, Spain"
      ],
      "name": "Paola Vidal-Montal"
    },
    {
      "affiliations": [
        "Hospital Universitario Dr. Peset, Rheumatology, Valencia, Spain"
      ],
      "name": "Carlos Valera-Ribera"
    },
    {
      "affiliations": [
        "Hospital Universitario Dr. Peset, Rheumatology, Valencia, Spain"
      ],
      "name": "Alida Taberner-Cortés"
    },
    {
      "affiliations": [
        "Complejo Asistencial Universitario de León, Rheumatology, León, Spain"
      ],
      "name": "Miriam Retuerto-Guerrero"
    },
    {
      "affiliations": [
        "Complejo Asistencial Universitario de León, Rheumatology, León, Spain"
      ],
      "name": "Clara Moriano-Morales"
    },
    {
      "affiliations": [
        "Hospital Universitario de Cabueñes, Rheumatology, Gijón, Spain"
      ],
      "name": "Anahy Mª Brandy-García"
    },
    {
      "affiliations": [
        "Hospital Universitario de Cabueñes, Dermatology, Gijón, Spain"
      ],
      "name": "Rubén Barros-Tornay’s"
    },
    {
      "affiliations": [
        "Hospital Universitario Virgen Macarena, Rheumatology, Sevilla, Spain"
      ],
      "name": "Virginia Moreira-Navarrete"
    },
    {
      "affiliations": [
        "Hospital Universitario Virgen Macarena, Rheumatology, Sevilla, Spain"
      ],
      "name": "Carmen Domínguez-Quesada"
    },
    {
      "affiliations": [
        "Hospital Universitario Puerta de Hierro, Rheumatology, Madrid, Spain"
      ],
      "name": "Blanca García-Magallón"
    },
    {
      "affiliations": [
        "Hospital Universitario Puerta de Hierro, Rheumatology, Madrid, Spain"
      ],
      "name": "Carolina Merino-Argumánez"
    },
    {
      "affiliations": [
        "Hospital Clínic de Barcelona, Rheumatology, Barcelona, Spain"
      ],
      "name": "José A Gómez-Puerta"
    },
    {
      "affiliations": [
        "Hospital Clínic de Barcelona, Rheumatology, Barcelona, Spain"
      ],
      "name": "Juan C Sarmiento"
    },
    {
      "affiliations": [
        "Hospital de Mérida, Rheumatology, Mérida, Spain"
      ],
      "name": "Sara María Rojas-Herrera"
    },
    {
      "affiliations": [
        "Hospital de Mérida, Rheumatology, Mérida, Spain"
      ],
      "name": "Cristina Arciniega-Lario"
    },
    {
      "affiliations": [
        "Hospital General Universitario de Alicante Dr. Balmis, Rheumatology. Universidad Miguel Hernández, Alicante, Spain",
        "ISABIAL, Alicante, Spain"
      ],
      "name": "Paloma Vela-Casasemper"
    },
    {
      "affiliations": [
        "ISABIAL, Alicante, Spain"
      ],
      "name": "Rocío Caño-Alamed"
    },
    {
      "affiliations": [
        "Hospital Universitario Central Asturias, Rheumatology, Asturias, Spain"
      ],
      "name": "Ignacio Braña-Abascal"
    },
    {
      "affiliations": [
        "Hospital Universitario Central Asturias, Rheumatology, Asturias, Spain"
      ],
      "name": "Estefanía Pardo-Campo"
    },
    {
      "affiliations": [
        "Hospital Universitario de Gran Canaria Doctor Negrín, Rheumatology, Las Palmas de Gran Canaria, Spain"
      ],
      "name": "Íñigo Rua-Figueroa"
    },
    {
      "affiliations": [
        "Hospital Universitario de Gran Canaria Doctor Negrín, Rheumatology, Las Palmas de Gran Canaria, Spain"
      ],
      "name": "Jesús Cerdeña-Corrales"
    },
    {
      "affiliations": [
        "Hospital Clínico Universitario de Salamanca, Rheumatology, Salamanca, Spain"
      ],
      "name": "Olga Compán-Fernández"
    },
    {
      "affiliations": [
        "Hospital Clínico Universitario de Salamanca, Rheumatology, Salamanca, Spain",
        "Hospital Universitario Marina Baixa, Rheumatology, Villajoyosa, Spain"
      ],
      "name": "Marta Ibáñez-Martínez"
    },
    {
      "affiliations": [
        "Hospital Universitario 12 de Octubre, Rheumatology, Madrid, Spain"
      ],
      "name": "María Galindo-Izquierdo"
    },
    {
      "affiliations": [
        "Hospital Universitario 12 de Octubre, Rheumatology, Madrid, Spain"
      ],
      "name": "Raquel Zas-Vaamonde"
    },
    {
      "affiliations": [
        "Hospital Regional Universitario de Málaga, Rheumatology, Málaga, Spain"
      ],
      "name": "Sara Manrique-Arija"
    },
    {
      "affiliations": [
        "Hospital Regional Universitario de Málaga, Rheumatology, Málaga, Spain"
      ],
      "name": "Laura Cano-García"
    },
    {
      "affiliations": [
        "Complejo Hospitalario Universitario de Santiago, Rheumatology, Santiago, Spain"
      ],
      "name": "Eva María Pérez-Pampín"
    },
    {
      "affiliations": [
        "Hospital Universitario Marqués de Valdecilla, Rheumatology, Santander, Spain"
      ],
      "name": "Ricardo Blanco-Alonso"
    },
    {
      "affiliations": [
        "Hospital Universitari Mútua de Terrassa, Rheumatology, Terrassa, Spain"
      ],
      "name": "Elena Riera-Alonso"
    },
    {
      "affiliations": [
        "Hospital Universitario Reina Sofía, Rheumatology, Córdoba, Spain"
      ],
      "name": "Rafaela Ortega-Castro"
    },
    {
      "affiliations": [
        "Hospital Universitario Sierrallana, Rheumatology. IDIVAL. Torrelavega, Spain"
      ],
      "name": "Elena Aurreocoechea-Aguinaga"
    },
    {
      "affiliations": [
        "Hospital Universitari Germans Trias i Pujol, Rheumatology, Badalona, Spain"
      ],
      "name": "Anne Riveros-Frutos"
    },
    {
      "affiliations": [
        "Hospital Universitario La Paz, Rheumatology, Madrid, Spain"
      ],
      "name": "Cristina Bohórquez-Heras"
    },
    {
      "affiliations": [
        "Hospital universitario de la Princesa. IIS-Princesa, Rheumatology, Madrid, Spain"
      ],
      "name": "Eva Tomero-Muriel"
    },
    {
      "affiliations": [
        "Hospital Universitario Marina Baixa, Rheumatology, Villajoyosa, Spain"
      ],
      "name": "Jose Miguel Senabre-Gallego"
    },
    {
      "affiliations": [
        "Complejo Hospitalario Universitario de Pontevedra, Rheumatology, Pontevedra, Spain"
      ],
      "name": "Lucía Silva-Fernández"
    },
    {
      "affiliations": [
        "Hospital Universitario Virgen de la Arrixaca, Rheumatology, Murcia, Spain"
      ],
      "name": "Jenifer Esther Ruiz-Sara"
    },
    {
      "affiliations": [
        "Hospital Universitario Gregorio Marañón, Rheumatology, Madrid, Spain"
      ],
      "name": "Pablo Rodríguez-Merlo"
    },
    {
      "affiliations": [
        "Hospital General Universitario de Valencia, Rheumatology, Valencia, Spain"
      ],
      "name": "Mireia Sanmartín-Martínez"
    },
    {
      "affiliations": [
        "Hospital Universitario La Fe, Rheumatology, Valencia, Spain"
      ],
      "name": "Jose Andrés Román-Ivorra"
    },
    {
      "affiliations": [
        "Hospital Universitari Moisès Broggi, Rheumatology, Sant Joan Despí, Spain"
      ],
      "name": "Sergio Heredia-Martín"
    },
    {
      "affiliations": [
        "Hospital Universitario de Donostia, Rheumatology, Donostia, Spain"
      ],
      "name": "Joaquín Belzunegui-Otano"
    },
    {
      "affiliations": [
        "Hospital Universitario Virgen de la Concha, Rheumatology, Zamora, Spain"
      ],
      "name": "Ruth López-González"
    },
    {
      "affiliations": [
        "Hospital Universitario Príncipe de Asturias, Rheumatology, Madrid, Spain"
      ],
      "name": "Lucía Ruiz-Gutiérrez"
    },
    {
      "affiliations": [
        "Hospital del Mar, Rheumatology, Barcelona, Spain"
      ],
      "name": "Tarek Salman-Monte"
    },
    {
      "affiliations": [
        "Imidomics, Inc, Barcelona, Spain"
      ],
      "name": "Sergio H Martínez-Mateu"
    },
    {
      "affiliations": [],
      "name": "Clara Fermoselle-Pérez"
    },
    {
      "affiliations": [
        "Hospital Clínic de Barcelona, Rheumatology, Barcelona, Spain"
      ],
      "name": "Juan D Cañete"
    },
    {
      "affiliations": [
        "Imidomics, Inc, Barcelona, Spain"
      ],
      "name": "Sara Marsal"
    }
  ],
  "title": "PO:13:342 Do diet habits influence the quality of life of patients with systemic lupus erythematosus? Results from baseline clinical data of the multi-omic multi-institutional SMILES study",
  "uid": "b492ecb4-77e9-573e-bef4-77f55d9ee932"
}