{
  "abstract": "Objectives To examine risk factors associated with cardiovascular (CV) events in a cohort of lupus patients from Latin America and to test the potential utility of the monocyte/HDL ratio (MHR), a known biomarker for CV events, in this population.Methods A cross-sectional, retrospective, multinational study including patients from Latin America. Data were collected from clinical charts. CV events were defined as either angina, myocardial infarction (MI), stroke (S), or transient ischemic accident (TIA). Univariate, multivariate, and discriminant analyses were performed. The BioEthics committees of the participating centers approved the study.Results A total of 734 patients were included (91% female, 78% mestizo, with a mean age at diagnosis of 31 years). Patients with CV events were older at diagnosis and more frequently had hypertension, diabetes, dyslipidemia, and renal involvement compared with those without events. In the multivariable logistic regression analysis, older age at diagnosis [OR 1.03 (95% CI 1.02–1.05), p<0.001], dyslipidemia [OR 2.92 (1.97–4.35), p<0.001], and renal lupus [OR 3.00 (2.07–4.38), p<0.001] were associated with CV; MHR also showed significant associations [OR 1.03 (1.00–1.07), p=0.027].Discriminant analysis generated three clusters. Cluster 1 was characterized by most mestizo patients, renal involvement, and a higher frequency of steroid use. Cluster 2 presented dyslipidemia, hematological manifestations, and greater use of methotrexate and azathioprine. Cluster 3 showed a higher frequency of anti-DNA antibodies, hematological, and neuropsychiatric manifestations. There were no differences in the MHR index or in cholesterol, HDL, or LDL levels. Notably, LDL was greater than 95 mg/dL and HDL was less than 45 mg/dL in all groups.The distribution of cardiovascular events—although infrequent MI (4), angina (6), stroke (16), and TIA (3)—did not show differences between the groups.Abstract PO:03:072 Table 1Variables associated with cardiovascular riskConclusions A higher age at diagnosis and the presence of three classical risk factors in the general population conferred an increased risk for CV events in this Latin-American lupus population. Patients with renal lupus were at higher risk. No association was observed with past or current smoking, autoantibody profile, or treatment modality. Further study is necessary to determine the value of MHR as a risk biomarker for CV risk in SLE.",
  "authors": [
    {
      "affiliations": [
        "RIBLES, Granada, Spain"
      ],
      "name": "Martin Rodriguez"
    },
    {
      "affiliations": [
        "RIBLES, Granada, Spain"
      ],
      "name": "Gloria Vásquez"
    },
    {
      "affiliations": [
        "RIBLES, Granada, Spain"
      ],
      "name": "Roberto Muñoz"
    },
    {
      "affiliations": [
        "RIBLES, Granada, Spain"
      ],
      "name": "Teresandris Polanco"
    },
    {
      "affiliations": [
        "RIBLES, Granada, Spain"
      ],
      "name": "Lucila Garcia"
    },
    {
      "affiliations": [
        "RIBLES, Granada, Spain"
      ],
      "name": "Carla Gobbi"
    },
    {
      "affiliations": [
        "RIBLES, Granada, Spain"
      ],
      "name": "Manuel Ugarte"
    },
    {
      "affiliations": [
        "RIBLES, Granada, Spain"
      ],
      "name": "Rosana Quintana"
    },
    {
      "affiliations": [
        "RIBLES, Granada, Spain"
      ],
      "name": "Ana Blasini"
    },
    {
      "affiliations": [
        "RIBLES, Granada, Spain"
      ],
      "name": "Concepcion Marañon"
    },
    {
      "affiliations": [
        "RIBLES, Granada, Spain"
      ],
      "name": "Karen Roberts"
    }
  ],
  "title": "PO:03:072 Risk factors for cardiovascular events in a Latin America population of patients with systemic lupus erythematosus",
  "uid": "9692c19a-bd7b-5659-83f4-0b7d3d8d4b55"
}