{
  "abstract": "Objectives There is limited data on the clinical manifestations, serologic profile and outcomes of patients with APS in the Philippine setting.This study aimed to determine the clinical and serologic profile of Filipino patients with APS.Specifically, the study aimed to:1. Determine the number of patients that are confirmed to have APS based on either Sapporo or ACR/EULAR criteria.2. Describe the demographic profile of patients diagnosed with primary and secondary APS.3. Discuss the clinical characteristics among the participants: i. Obstetrical outcomes ii. Thrombotic events iii. Anti-phospholipid antibody profile iv. Hospital admission and consult4. Determine association of clinical outcomes and anti-phospholipid antibody profile among the participants.Methods A retrospective study was done to identify patients diagnosed with APS in St Luke’s Medical Center Quezon City and St. Luke’s Medical Center Global City from January 1, 2018, to January 31, 2025, using the census of the section of Rheumatology and electronic medical records. The demographics, obstetric outcomes thrombotic events and values for anti-phospholipid antibodies were recorded. Statistical association between criteria anti-phospholipid antibodies and clinical manifestations, was determined using multinomial logistic regression. Technical and ethics approval was obtained for this study. Patient confidentiality was respected by ensuring anonymity of patient records.Results Among 232 patients referred for consideration of APS, 98 patients (42.24%) met the diagnostic criteria. Majority were female (82.65%) with an average age of 42 at diagnosis. Secondary APS (63.27%) from systemic lupus (64.29%) was commonly observed.Initial presentation at diagnosis varied, but cerebrovascular disease (29.59%), deep vein thrombosis (15.31%) and obstetric complications (13.27%) were most common. Majority (72.45%) required hospital admission due to complications from APS. Only one mortality, due to pneumonia, was identified. Most patients had a positive LAC (85.71%). LAC was significantly associated with an increased likelihood of both arterial (OR = 5.30, p=0.048) and venous thrombosis (OR= 9.25, p=0.021) as compared to non-thrombotic events. However, aCL and B2-GPI antibodies were found to have no statistically significant association with any clinical manifestation.Abstract PO:01:024 Table 1Baseline characteristics of identified patients with Primary vs Secondary APS in two private tertiary hospitalsConclusions Given the conflicting data on the association between clinical presentation and different serologic profiles, further association studies with large tapopulations for each subset could be beneficial.",
  "authors": [
    {
      "affiliations": [
        "St. Luke’s Medical Center Department of Internal Medicine, Section of Rheumatology, Quezon City, Philippines"
      ],
      "name": "Cristina Dorado"
    },
    {
      "affiliations": [
        "St. Luke’s Medical Center Department of Internal Medicine, Section of Rheumatology, Quezon City, Philippines"
      ],
      "name": "Melissa Aquino-Villamin"
    }
  ],
  "title": "PO:01:024 Clinical manifestations and outcomes of filipino patients with anti-phospholipid syndrome: a tertiary private hospital study",
  "uid": "9588c553-42bf-5f50-ad4b-9c4e52499480"
}