{
  "abstract": "Objectives SLE is a multisystemic autoimmune disease. Pleuropulmonary (PP) manifestations, including pleural effusion (PE), interstitial lung disease (ILD), pulmonary hypertension (PH), shrinking lung syndrome (SLS), and alveolar hemorrhage (AH) have been described; however, data on their frequency and associated risk factors are scarce in the Latin American SLE population. A better understanding of PP manifestations in this population is crucial due to the risk of severe and irreversible damage, and impact on morbidity, mortality, and quality of life.Methods Patients from the Latin American GLADEL 2.0 cohort who met the ACR/EULAR 2019 and/or the SLICC SLE classification criteria were included. Patients with PP manifestations (PE/ILD/PH/SLS/AH) were compared to those without PP manifestations. Patients with polyautoimmunity where the disease could have another explanation, were excluded. Univariate (UV) analyses were conducted to determine associations for each PP manifestation, using data recorded prior to the report of the manifestation. Multivariate (MV) logistic regression analyses were performed, adjusting for age, gender, and other variables found to be significant in UV analyses (P<0.05).Results From 1,083 patients in the cohort, 242 patients with PE, 38 with ILD, 26 with PH, 20 with SLS, and 9 with AH were identified. Factors associated with each manifestation, except for AH (due to small n), are summarized in table 1. Age at diagnosis, disease duration, history of renal involvement (active and inactive nephritis), and degree of organ damage, assessed with the SLICC Damage Index (SDI), were frequently associated with PP manifestations. In the MV analysis, the association between SDI and PP remained statistically significant for all complications. Disease activity (per SLEDAI-2K) was only found to be significant for PE (P=0.001). Significant associations between the presence of serositis and PH (P=0.005) and SLS (P=0.001) were found.Abstract PO:03:085 Table 1Conclusions Damage (per SDI), was a consistent risk factor associated with PP manifestations; this risk factor has not been previously reported for PP in SLE. These data highlight the importance of close monitoring for PP in patients with SLE who have organ damage. Additionally, serositis significantly increased the risk of developing PH and SLS in this cohort, consistent with data reported in previous studies.",
  "authors": [
    {
      "affiliations": [
        "Centro Regional de Enfermedades Autoinmunes y Reumáticas, GO-CREAR, Rosario, Argentina"
      ],
      "name": "Bernardo Pons Estel"
    },
    {
      "affiliations": [
        "Hospital Universitario Nacional de Colombia, Bogotá, Colombia"
      ],
      "name": "Luis Javier Cajas Santana"
    },
    {
      "affiliations": [
        "Hospital Universitario Nacional de Colombia, Bogotá, Colombia"
      ],
      "name": "Sebastián Molina Ríos"
    },
    {
      "affiliations": [
        "Consultora Externa Gladel"
      ],
      "name": "Lucia Hernández"
    },
    {
      "affiliations": [
        "Centro Regional de Enfermedades Autoinmunes y Reumáticas, GO-CREAR, Rosario, Argentina"
      ],
      "name": "Romina Nieto"
    },
    {
      "affiliations": [
        "Hospital Italiano de Buenos Aires, Buenos Aires, Argentina"
      ],
      "name": "Gricel Maita Romero"
    },
    {
      "affiliations": [
        "Hospital Italiano de Córdoba, Córdoba, Argentina"
      ],
      "name": "Nidia Noemí Merás"
    },
    {
      "affiliations": [
        "Universidad Nacional de Córdoba, Córdoba, Argentina"
      ],
      "name": "Veronica Gabriela Savio"
    },
    {
      "affiliations": [
        "Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina"
      ],
      "name": "Verónica Saurit"
    },
    {
      "affiliations": [
        "Hospital San Martin de La Plata",
        "La Plata, Argentina"
      ],
      "name": "Valeria Arturi"
    },
    {
      "affiliations": [
        "Sanatorio Británico, Rosario, Argentina"
      ],
      "name": "Boris Kisluk"
    },
    {
      "affiliations": [
        "Hospital Padilla, Tucumán, Argentina"
      ],
      "name": "Verónica Bellomio"
    },
    {
      "affiliations": [
        "Hospital J.M Ramos Mejía, Buenos Aires, Argentina"
      ],
      "name": "Eduardo Mario Kerzberg"
    },
    {
      "affiliations": [
        "Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires",
        "Buenos Aires, Argentina"
      ],
      "name": "Nicolás Perez"
    },
    {
      "affiliations": [
        "CEMIC Centro de Educación Médica e Investigaciones Clínicas ‘‘Norberto Quirno’, Buenos Aires, Argentina"
      ],
      "name": "Cecilia Nora Pisoni"
    },
    {
      "affiliations": [
        "Hospital Señor del Milagro Salta, Salta, Argentina"
      ],
      "name": "Vicente Juárez"
    },
    {
      "affiliations": [
        "Hospital General de Agudos Dr. Juan A. Fernández, Buenos Aires, Argentina"
      ],
      "name": "Joaquín Martinez Serventi"
    },
    {
      "affiliations": [
        "Hospital das Clinicas da Universidade Federal de Goias, Goias, Brazil"
      ],
      "name": "Nilzio Antonio Da Silva"
    },
    {
      "affiliations": [
        "Hospital de Clínicas de Porto Alegre, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil"
      ],
      "name": "Odirlei Andre Monticielo"
    },
    {
      "affiliations": [
        "Universidad Federal de Pernambuco, Recife, Brazil"
      ],
      "name": "Mariana Souza Pessoa De Luna"
    },
    {
      "affiliations": [
        "Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil"
      ],
      "name": "Laíssa Cristina Alves Alvino"
    },
    {
      "affiliations": [
        "Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil"
      ],
      "name": "Eduardo F Borba"
    },
    {
      "affiliations": [
        "Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil"
      ],
      "name": "Luciana Parente Costa Seguro"
    },
    {
      "affiliations": [
        "Escola Paulista de Medicina/Universidade federal de São Paulo (EPM/Unifesp), São Paulo, Brazil"
      ],
      "name": "Edgard Torres Dos Reis-Neto"
    },
    {
      "affiliations": [
        "Hospital del Salvador Santiago de Chile, Santiago, Chile"
      ],
      "name": "Iris Guerra Herrera"
    },
    {
      "affiliations": [
        "Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile"
      ],
      "name": "Milena Mimica"
    },
    {
      "affiliations": [
        "Clínica de la Costa y Universidad Simón Bolívar Barranquilla, Barranquilla, Colombia"
      ],
      "name": "Gustavo Aroca Martínez"
    },
    {
      "affiliations": [
        "Clínica de la Costa y Universidad Simón Bolívar Barranquilla, Barranquilla, Colombia"
      ],
      "name": "Valentina Pérez Jiménez"
    },
    {
      "affiliations": [
        "Fundación Valle del Lili, Universidad Icesi, Cali, Colombia"
      ],
      "name": "Carlos A Cañas"
    },
    {
      "affiliations": [
        "Facultad de Medicina, Universidad Nacional de Colombia",
        "Servicio de reumatología, Hospital Universitario Fundación Santa Fe de Bogotá",
        "Hospital Universitario Nacional de Colombia, Bogotá, Colombia"
      ],
      "name": "Gerardo Quintana-Lopez"
    },
    {
      "affiliations": [
        "Centro de Referencia en Osteoporosis and Reumatología Pontificia Universidad Javeriana de Cali, Cali, Colombia"
      ],
      "name": "Carlos Enrique Toro Gutiérrez"
    },
    {
      "affiliations": [
        "Universidad de Especialidades Espíritu Santo, Guayaquil, Ecuador"
      ],
      "name": "Rafael Ignacio López Martínez"
    },
    {
      "affiliations": [
        "Hospital de Especialidades Dr. Antonio Fraga Mouret, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico"
      ],
      "name": "Miguel Ángel Saavedra"
    },
    {
      "affiliations": [
        "Hospital de especialidades del centro médico nacional SXXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico"
      ],
      "name": "Margarita Portela Hernández"
    },
    {
      "affiliations": [
        "Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán",
        "Mexico City, Mexico"
      ],
      "name": "Hilda Fragoso-Loyo"
    },
    {
      "affiliations": [
        "Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico"
      ],
      "name": "Luis H Silveira"
    },
    {
      "affiliations": [
        "Centro de Estudios de Investigación Básica y Clínica, S.C., Guadalajara, Mexico"
      ],
      "name": "Yelitza C González-Bello"
    },
    {
      "affiliations": [
        "Facultad de Medicina de la Universidad Autónoma de San Luis Potosí y Hospital Central ‘Dr. Ignacio Morones Prieto’, San Luis Potosí, Mexico"
      ],
      "name": "Carlos Abud-Mendoza"
    },
    {
      "affiliations": [
        "Hospital Universitario ‘Dr. José Eleuterio Gonzalez’, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México"
      ],
      "name": "Jorge A Esquivel Valerio"
    },
    {
      "affiliations": [
        "Facultad de Ciencias Medicas, Universidad Nacional de Asunción, San Lorenzo, Paraguay"
      ],
      "name": "Patricia Langjahr"
    },
    {
      "affiliations": [
        "Facultad de Ciencias Medicas, Universidad Nacional de Asunción, San Lorenzo, Paraguay"
      ],
      "name": "Astrid Paats"
    },
    {
      "affiliations": [
        "Hospital Nacional Edgardo Rebagliati Martins-EsSalud, Lima, Peru"
      ],
      "name": "Claudia Mora-Trujillo"
    },
    {
      "affiliations": [
        "Universidad Científica del Sur, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Peru"
      ],
      "name": "Victor R Pimentel-Quiroz"
    },
    {
      "affiliations": [
        "Hospital Nacional Cayetano Heredia, Universidad Peruana Cayetano Heredia, Lima, Peru"
      ],
      "name": "Carlos Bedia"
    },
    {
      "affiliations": [
        "Hospital Docente Padre Billini, Santo Domingo, Dominican Republic"
      ],
      "name": "Teresandris Polanco"
    },
    {
      "affiliations": [
        "Hospital de Clínicas, Facultad de Medicina, UDELAR, Montevideo, Uruguay"
      ],
      "name": "Martín Rebella"
    },
    {
      "affiliations": [
        "Médica Uruguaya, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay"
      ],
      "name": "Álvaro Danza"
    },
    {
      "affiliations": [
        "Johnson and Johnson, Horsham, PA,USA"
      ],
      "name": "Federico Zazzetti"
    },
    {
      "affiliations": [
        "Johnson and Johnson, Spring House, PA, USA"
      ],
      "name": "Ashley Orillion"
    },
    {
      "affiliations": [
        "Centro Regional de Enfermedades Autoinmunes y Reumáticas, GO-CREAR, Rosario, Argentina"
      ],
      "name": "Guillermo Pons-Estel"
    },
    {
      "affiliations": [
        "The University of Alabama at Birmingham Marnix E. Heersink School of Medicine, Birmingham, AL, USA",
        "School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Perú"
      ],
      "name": "Graciela S Alarcón"
    }
  ],
  "title": "PO:03:085 Risk factors for pulmonary manifestations in GLADEL 2.0, a systemic lupus erythematosus Latin American cohort",
  "uid": "891a85e3-86cd-5d3c-9d69-aa46af805e24"
}