{
  "abstract": "Objectives In patients with SLE treated with ANI in clinical practice in Spain, our aim was to assess a) the profile of patients receiving ANI b) effectiveness and c) safety.Methods Observational multicenter study of patients diagnosed with SLE (EULAR/ACR 2019 classification criteria) treated with ANI. Demographic, clinical, laboratory, and pathologic variables were evaluated, along with previous and concomitant therapies, disease activity indices (SLE-DAS, SLEDAI-2K, PGA), organ damage index (SDI), and safety were evaluated.Results 206 patients (183 females/23 males), mean age 44.6 ± 12.6 years (range 15-90 years) (54 hospitals) were included. Baseline characteristics of patients and prior treatment before starting ANI are summarized in table 1.The main reason for starting ANI was clinical activity: cutaneous (61.7%), articular (48.5%), hematological (27.2%), corticosteroid dependence (5.4%), renal (4%), serositis (3%), serious adverse events with other immunosuppressants (1.9%), neurological (1%), and Kikuchi disease (0.5%).The mean number of immunosuppressants received prior to ANI was 2.5±1.6 (range 0-8). All patients received 300 mg/4 weeks of ANI except two patients with renal involvement who received a loading dose. In addition to corticosteroids and antimalarials, ANI was administered in many cases concomitantly with other immunomodulator drug (table 1).A rapid (from the 1st month) and maintained significant improvement was observed in: a) disease activity (SLE-DAS, SLEDAI-2K, PGA) (figure 1) b) immunologic markers (decrease in anti-dsDNA antibody titers and normalization of C3 and C4 levels) (figure 1) and c) prednisone dose (figure 2). The organ damage index remained stable.After a mean follow-up of 7.5 ± 5.3 months, a reduction in the number of relapses was observed (median [IQR] of 2 [1-6] prior ANI to 0 [0-0] after ANI (p<0.001). The most relevant adverse events were: herpes zoster (n=5), headache (n=3), upper respiratory tract infection (n=3) and pneumonia (n=3). 20 patients discontinued treatment due to primary failure (n=8), secondary failure (n=3), severe infections (n=6), hypotension (n=1), acute anterior uveitis (n=1), and pregnancy desire (n=1).Abstract PO:11:301 Figures and TableConclusions A rapid and maintained effectiveness was observed even in severe and refractory patients. The safety profile was acceptable with the limitation of short follow-up.",
  "authors": [
    {
      "affiliations": [
        "Hospital Universitario Marqués de Valdecilla, Immunopathology group, IDIVAL, Santander, Spain"
      ],
      "name": "Vanesa Calvo-Río"
    },
    {
      "affiliations": [
        "Hospital Universitario Marqués de Valdecilla, Immunopathology group, IDIVAL, Santander, Spain"
      ],
      "name": "Carmen Secada-Gómez"
    },
    {
      "affiliations": [
        "Hospital Universitario Marqués de Valdecilla, Immunopathology group, IDIVAL, Santander, Spain"
      ],
      "name": "Adrián Martín-Gutiérrez"
    },
    {
      "affiliations": [
        "Hospital Universitario de León, León, Spain"
      ],
      "name": "M Retuerto-Guerrero"
    },
    {
      "affiliations": [
        "Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain"
      ],
      "name": "Judit Font"
    },
    {
      "affiliations": [
        "Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain"
      ],
      "name": "Ivette Casafont-Solé"
    },
    {
      "affiliations": [
        "Hospital Universitario Doctor Peset, Valencia, Spain"
      ],
      "name": "A Mayo-Juanatey"
    },
    {
      "affiliations": [
        "Hospital Universitario Doctor Peset, Valencia, Spain"
      ],
      "name": "Juan José Alegre Sancho"
    },
    {
      "affiliations": [
        "Hospital Clínico San Carlos, Madrid, Spain"
      ],
      "name": "Dalifer Freites"
    },
    {
      "affiliations": [
        "Hospital Clínico San Carlos, Madrid, Spain"
      ],
      "name": "Cristina Hormigos"
    },
    {
      "affiliations": [
        "Hospital Quirónsalud Infanta Luisa, Sevilla, Spain"
      ],
      "name": "Noemí Garrido Puñal"
    },
    {
      "affiliations": [
        "Hospital Universitario de A Coruña, A Coruña, Spain"
      ],
      "name": "Guillermo González Arribas"
    },
    {
      "affiliations": [
        "Hospital Universitario de Móstoles, Madrid, Spain"
      ],
      "name": "Juan Roberto Miguélez Sanchez"
    },
    {
      "affiliations": [
        "Hospital General Río Carrión, Palencia, Spain"
      ],
      "name": "Andrea García-Valle"
    },
    {
      "affiliations": [
        "Hospital Clínico Universitario de Salamanca, Salamanca, Spain"
      ],
      "name": "Marta Ibañez"
    },
    {
      "affiliations": [
        "Hospital Central de La Defensa Gómez Ulla, Madrid, Spain"
      ],
      "name": "Fernando Lozano Morillo"
    },
    {
      "affiliations": [
        "Hospital Universitario de Torrevieja, Alicante, Spain"
      ],
      "name": "Ángel García Manzanares"
    },
    {
      "affiliations": [
        "Hospital Universitario Vall d´Hebrón, Barcelona, Spain"
      ],
      "name": "S Sandoval-Moreno"
    },
    {
      "affiliations": [
        "Hospital Universitario Vall d´Hebrón, Barcelona, Spain"
      ],
      "name": "Josefina Cortés-Hernández"
    },
    {
      "affiliations": [
        "Hospital Rafael Méndez, Lorca, Murcia, Spain"
      ],
      "name": "Deseada Palma Sanchez"
    },
    {
      "affiliations": [
        "Hospital Universitario Infanta Leonor, Madrid, Spain"
      ],
      "name": "Leticia Lojo"
    },
    {
      "affiliations": [
        "Hospital Provincial de Pontevedra, Pontevedra, Spain"
      ],
      "name": "Evelin Cecilia Cervantes Pérez"
    },
    {
      "affiliations": [
        "Hospital Universitario Severo Ochoa, Madrid, Spain"
      ],
      "name": "Paz Collado"
    },
    {
      "affiliations": [
        "Hospital de Mérida, Badajoz, Spain"
      ],
      "name": "Cristina Arciniega Larios"
    },
    {
      "affiliations": [
        "Hospital Universitario de Torrejón, Madrid, Spain"
      ],
      "name": "Luis Sala Icardo"
    },
    {
      "affiliations": [
        "Hospital General de La Rioja, Logroño, Spain"
      ],
      "name": "Eztizen Labrador-Sánchez"
    },
    {
      "affiliations": [
        "Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain"
      ],
      "name": "Cilia Peralta-Ginés"
    },
    {
      "affiliations": [
        "Hospital Galdakao, Vizcaya, Spain"
      ],
      "name": "Irati Urionagüena Onaindia"
    },
    {
      "affiliations": [
        "Hospital Galdakao, Vizcaya, Spain"
      ],
      "name": "Nahia Plaza-Aulestia"
    },
    {
      "affiliations": [
        "Hospital de Calahorra, La Rioja, Spain"
      ],
      "name": "Miguel Medina Malone"
    },
    {
      "affiliations": [
        "Hospital Marina Baixa, Villajoyosa, Alicante, Spain"
      ],
      "name": "José Rosas Gómez De Salazar"
    },
    {
      "affiliations": [
        "Complejo Asistencial de Ávila, Ávila, Spain"
      ],
      "name": "Montserrat Corteguera"
    },
    {
      "affiliations": [
        "Hospital Universitario Infanta Leonor, Madrid, Spain"
      ],
      "name": "Laura Cebrián-Méndez"
    },
    {
      "affiliations": [
        "Hospital General de Segovia, Segovia, Spain"
      ],
      "name": "Fred Antonio Antón Pages"
    },
    {
      "affiliations": [
        "Hospital Universitario del Henares, Coslada, Madrid, Spain"
      ],
      "name": "José Ramón Lamua Riazuelo"
    },
    {
      "affiliations": [
        "Hospital de Barbastro, Huesca, Spain"
      ],
      "name": "María Dolores Fábregas Canales"
    },
    {
      "affiliations": [
        "Hospital Universitario Puerta del Mar, Cádiz, Spain"
      ],
      "name": "María José Alados Hernández"
    },
    {
      "affiliations": [
        "Hospital de Sagunto, Valencia, Spain"
      ],
      "name": "Marta Garijo Bufort"
    },
    {
      "affiliations": [
        "Hospital Verge de la Cinta, Tortosa, Tarragona, Spain"
      ],
      "name": "Anna Pàmies"
    },
    {
      "affiliations": [
        "Complejo Hospitalario de Jaén, Jaén, Spain"
      ],
      "name": "Luis Sarabia De Ardanaz"
    },
    {
      "affiliations": [
        "Hospital Universitario Lucus Augusti, Lugo, Spain"
      ],
      "name": "Rodrigo Aguirre-Del-Pino"
    },
    {
      "affiliations": [
        "Complejo Asistencial de Zamora, Zamora, Spain"
      ],
      "name": "José Ángel Cabezas Lefler"
    },
    {
      "affiliations": [
        "Hospital Universitario Lucus Augusti, Lugo, Spain"
      ],
      "name": "Álvaro Seijas-Lopez"
    },
    {
      "affiliations": [
        "Complejo Hospitalario Universitario de Badajoz, Badajoz, Spain"
      ],
      "name": "María Del Carmen Carrasco Cubero"
    },
    {
      "affiliations": [
        "Hospital Santa Bárbara, Soria, Spain"
      ],
      "name": "Ana López-Cerón Cofiño"
    },
    {
      "affiliations": [
        "Hospital General de Granollers, Barcelona, Spain"
      ],
      "name": "Vera Ortiz-Santamaria"
    },
    {
      "affiliations": [
        "Hospital Universitario de Navarra, Pamplona, Spain"
      ],
      "name": "María Laiño Piñeiro"
    },
    {
      "affiliations": [
        "Hospital Universitario de Cabueñes, Gijón, Spain"
      ],
      "name": "Carmen Ordás Calvo"
    },
    {
      "affiliations": [
        "Hospital Universitario Infanta Elena, Valdemoro, Madrid, Spain"
      ],
      "name": "Celia Arconada Lopez"
    },
    {
      "affiliations": [
        "Hospital Universitario Son Espases, Palma de Mallorca, Baleares, Spain"
      ],
      "name": "Ana Urruticoechea-Arana"
    },
    {
      "affiliations": [
        "Hospital Universitario Puerta de Hierro, Madrid, Spain"
      ],
      "name": "Blanca Garcia Magallon"
    },
    {
      "affiliations": [
        "Hospital Univ. Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain"
      ],
      "name": "Ana Valeria Acosta Alfaro"
    },
    {
      "affiliations": [
        "Hospital Universitario La Fe, Valencia, Spain"
      ],
      "name": "Samuel Leal Rodriguez"
    },
    {
      "affiliations": [
        "Hospital Infanta Cristina, Parla, Madrid, Spain"
      ],
      "name": "Marina Salido Olivares"
    },
    {
      "affiliations": [
        "Hospital General de Villalba, Collado Villalba, Madrid, Spain"
      ],
      "name": "Patricia Lavilla Villar"
    },
    {
      "affiliations": [
        "Hospital Universitario de Cabueñes, Gijón, Spain"
      ],
      "name": "Anahy M Brandy-García"
    },
    {
      "affiliations": [
        "Hospital Son Llàtzer, Manacor, Spain"
      ],
      "name": "Inmaculada Ros Vilamajo"
    },
    {
      "affiliations": [
        "Hospital del Tajo, Aranjuez, Madrid, Spain"
      ],
      "name": "Álvaro García Martos"
    },
    {
      "affiliations": [
        "Hospital Santa Creu i Sant Pau, Barcelona, Spain"
      ],
      "name": "Berta Paula Magallares Lopez"
    },
    {
      "affiliations": [
        "Hospital Reina Sofía, Tudela, Navarra, Spain"
      ],
      "name": "Guillén Sada Urmeneta"
    },
    {
      "affiliations": [
        "Hospital Universitario Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Canarias, Spain"
      ],
      "name": "Cristina Córdoba Martín"
    },
    {
      "affiliations": [
        "Hospital Universitario Mútua Terrassa, Barcelona, Spain"
      ],
      "name": "Elena Riera"
    },
    {
      "affiliations": [
        "Hospital Universitario Marqués de Valdecilla, Immunopathology group, IDIVAL, Santander, Spain"
      ],
      "name": "Carmen Bejerano"
    },
    {
      "affiliations": [
        "Hospital de La Princesa, IIS-Princesa, Madrid, Spain"
      ],
      "name": "Santos Castañeda"
    },
    {
      "affiliations": [
        "Hospital Universitario Marqués de Valdecilla, Immunopathology group, IDIVAL, Santander, Spain"
      ],
      "name": "Ricardo Blanco"
    }
  ],
  "title": "PO:11:301 Anifrolumab in systemic lupus erythematosus. spanish multicenter registry in clinical practice",
  "uid": "7010c122-c187-52db-add3-2565098c0424"
}