{
  "abstract": "Objectives SLE is associated with significant morbidity and healthcare burden. SLE incidence estimates help inform research and public health initiatives. SLE incidence estimates may be affected by health care access or care-seeking behaviour and/or by environmental factors (e.g. viral triggers, climate change). We estimated annual SLE incidence rates over time, using real-world US data.Methods Using the Merative™ MarketScan® Commercial (+/-Medicare Supplemental) databases, we identified adults (18+) with 2 or more years of continuous enrollment and no SLE diagnoses during those 2 years between Jan. 2016-Dec. 2022. A 20% random sample was selected for analysis. Time zero was first qualifying date for cohort entry. Incident SLE defined by International Classification of Diseases diagnostic codes, based on 2 or more physician visits at least 8 weeks apart within two years and/or 1 or more hospitalizations. Individuals followed from time zero until earliest SLE diagnosis, health plan disenrollment, or end of follow-up. Annual SLE incidence rates calculated with 95% confidence intervals (CI). We report incidence overall and stratified by sex. Female-specific rates further stratified according to whether person-time was contributed during reproductive age (age<52). We assessed age (continuous) and sex in a multivariate hazard regression predicting SLE onset, controlling for calendar year.Results We analyzed 4.6 million individuals followed an average of 2.8 years (standard deviation, SD 2.2); 52.6% female, mean age at time zero 43.1 years (SD 14.8). 1,593 new SLE cases (89.2% female) identified across 12.9 million person-years,PY (12.3 events per 100,000 PY). No clear difference in incidence comparing 2020-2022 (12.6 events/100,000 PY) versus 2016-2019 (12.2 events/100,000 PY). In any given calendar year, incidence was greater among females, higher incidence during reproductive years (23.3 events/100,000 PY 95% CI21.9-24.9) versus later (16.8 events/100,000 PY; 95% CI15.3-18.5) ( table 1). In multivariate models, hazard ratios (HR) for female sex was 7.47 (95%CI 6.38-8.75) and for age (continuous),1.00 (95% CI1.00, 1.01).Abstract PO:07:197 Table 1Annual SLE incidence by 10,000 person-years with 95% CI, US MarketScan, 2016-2022*Conclusions These clinically relevant real-world data suggest SLE incidence in the US is holding steady, during the period 2016-2022. Limitations of our analyses include selection bias (all individuals had private insurance), short average follow-up time, and possible outcome misclassification (e.g. prevalent SLE cases mischaracterized as incident).",
  "authors": [
    {
      "affiliations": [
        "Research Institute of the McGill University Health Centre, Montreal, Canada"
      ],
      "name": "Sasha Bernatsky"
    },
    {
      "affiliations": [
        "Baptist Memorial, Jonesboro, USA"
      ],
      "name": "Sharon Dowell"
    },
    {
      "affiliations": [
        "Mount Sinai, New York, USA"
      ],
      "name": "Brittany Banbury"
    },
    {
      "affiliations": [
        "University of Alabama at Birmingham, Birmingham, USA",
        "Foundation for Advancing Science, Technology, Education and Research (FASTER), Hoover, USA"
      ],
      "name": "Jeffrey Curtis"
    },
    {
      "affiliations": [
        "Grace Wright, New York, USA"
      ],
      "name": "Grace C Wright"
    },
    {
      "affiliations": [
        "University of Alabama at Birmingham, Birmingham, USA",
        "Foundation for Advancing Science, Technology, Education and Research (FASTER), Hoover, USA"
      ],
      "name": "Emily Holladay"
    },
    {
      "affiliations": [
        "Foundation for Advancing Science, Technology, Education and Research (FASTER), Hoover, USA"
      ],
      "name": "Amy Mudano"
    },
    {
      "affiliations": [
        "Research Institute of the McGill University Health Centre, Montreal, Canada"
      ],
      "name": "Cristiano S Moura"
    },
    {
      "affiliations": [
        "VAMC/HUH/GTU, Washington, USA"
      ],
      "name": "Gail Kerr"
    }
  ],
  "title": "PO:07:197 Temporal trends in the incidence of systemic lupus erythematosus (SLE) in the United States (US): holding steady?",
  "uid": "69d59790-08bb-515a-aee2-9c47de7b5ef0"
}