{
  "abstract": "Objectives Systemic Lupus Erythematosus (SLE) can have a substantial impact on health-related quality of life (HRQL). RAND12/SF12 is a generic tool, measuring 8 subscales of HRQL (physical function, role physical, bodily pain, global health, vitality (VT), social function (SF), role emotional (RE) and mental health (MH)) on a scale from 0-100. These subscales can be combined to form two summary composite scores, the Physical Component Summary (PCS) and Mental Component Summary (MCS).1. To describe the four domains of RAND12 associated with mental health (MH, VT, RE and SF), and the Mental Component Summary score (MCSs) throughout pregnancy and the first year postpartum in women with SLE2. To compare the MCSs of the study population to the norm value for healthy Norwegian women of the same ageMethods We prospectively collected data on RAND12 in women with SLE through the nationwide Norwegian registry on pregnancy and rheumatic diseases (RevNatus) from January 2016 - September 2025. All diagnosed prior to pregnancy with ICD-10 codes M32.1, M32.8 or M32.9 . Data from seven timepoints were retrieved (pre-pregnancy, 1st, 2nd and 3rd trimester, 6 weeks, 6 months and 12 months postpartum).One sample t-test was used comparing the MCSs of the study population with expected population mean from the norm calculator (healthy Norwegian women of the same age as the study population (pregnancy status unknown)) (PubMed Identifier: 35659237 and 28808829).Results 181 women with 230 pregnancies resulting in live births were included. Mean age at 6 weeks postpartum was 31.9 years (Standard Deviation (SD) 4.6). Mean disease duration was 8.4 years (SD 5.3). Mean gestational age was 37.7 weeks (SD 4.7). During pregnancy 68% used hydroxychloroquine (HCQ) in monotherapy, 23% used a combination of HCQ and azathioprine (AZA), 3% used AZA in monotherapy and 90% used low-dose aspirin.Abstract PO:08:206 Table 1–2Conclusions In this large cohort, we found the MH-domain to be stable and good throughout pregnancy and the first year postpartum. However, the MCSs was significant lower in 1st trimester, 3rd trimester and 12 months postpartum in patients compared to norm-data. The MCSs also includes the domain Vitality that is particularly low at these timepoints.",
  "authors": [
    {
      "affiliations": [
        "St Olavs hospital, Trondheim University Hospital, Norwegian National Network for Pregnancy and Rheumatic Diseases, Trondheim, Norway"
      ],
      "name": "Hege Svean Koksvik"
    },
    {
      "affiliations": [
        "St Olavs hospital, Trondheim University Hospital, Norwegian National Network for Pregnancy and Rheumatic Diseases, Trondheim, Norway"
      ],
      "name": "Ingrid Rekaa Nilssen"
    },
    {
      "affiliations": [
        "St Olavs hospital, Trondheim University Hospital, Norwegian National Network for Pregnancy and Rheumatic Diseases, Trondheim, Norway"
      ],
      "name": "Bente Jakobsen"
    },
    {
      "affiliations": [
        "St Olavs hospital, Trondheim University Hospital, Norwegian National Network for Pregnancy and Rheumatic Diseases, Trondheim, Norway",
        "Norwegian University of Science and Technology (NTNU), Institute of Neuromedicine and Movement Science, Trondheim, Norway"
      ],
      "name": "Marianne Wallenius"
    }
  ],
  "title": "PO:08:206 Mental health through pregnancy and postpartum in Norwegian women with SLE -results from the nationwide register RevNatus",
  "uid": "6168a14a-8d66-5869-86fc-6c0b1d290608"
}