{
  "abstract": "Objectives To assess the prevalence and 5-year incidence of autoimmune diseases (ADs) in Swedish cohort of patients with antiphospholipid syndrome (APS) compared with matched population controls with a particular focus on the influence of a high-risk antiphospholipid antibody (aPL) profile, categorized as triple aPL positivity.Methods This retrospective, registry-based cohort study included 250 APS patients diagnosed at Karolinska University Hospital (2014-2020), according to the revised Miyakis et al. (2006) criteria. The subgroup with triple aPL positivity was identified accordingly. Baseline prevalence and 5-year incidence of ADs were assessed. Population comparators, matched 5:1 by birth year, sex, and residence, were identified through Swedish National Patient Register and Total Population Register. ADs were classified as rheumatic (RADs) or non-rheumatic (NRADs) based on ICD-10 codes. Logistic regression estimated adjusted odds ratios (aORs) for baseline ADs. Poisson regression was used for incidence rate ratios (IRR).Results The cohort included 250 patients had a median age of 44.5 years (IQR 35–59); 68% were women. At baseline, 127 patients (51%) had one or more ADs. Among them, 96 (38%) had RAD and 55 (22%) had NRAD. Systemic lupus erythematosus was the most common RAD (30%), whereas autoimmune thyroid disease was the most prevalent among NRADs (10%). High risk aPL-profile was observed in 48% of patients. Adjusted for age and sex, triple positivity was associated with an increased odds of having a coexisting AD (aOR = 1.6; 95% CI: 1.0–2.6) ( figure 1). During follow-up, APS patients demonstrated a significantly higher incidence of newly diagnosed ADs compared to controls. The incidence rate IR was 8 per 1,000 person-years. During follow-up, APS patients exhibited a significantly higher incidence of newly diagnosed ADs compared to controls, with IRR adjusted for age and sex of 7.5 (95% CI: 4.4-13.0) (figure 1).Abstract PO:01:020 Figure 1Cumulative in cidence curve of newly diagnosed autoimmune diseases (ADs)Conclusions APS patients are at a considerably higher risk than the general population of both having a coexisting AD and developing a new one over time, particularly those with a high-risk aPL profile. These findings support the need for comprehensive screening, risk stratification and evaluation of tailored treatment strategies.",
  "authors": [
    {
      "affiliations": [
        "Karolinska Institutet, Department of Medicine Solna, Division of Rheumatology, Stockholm, Sweden"
      ],
      "name": "Natali Karandyszowska"
    },
    {
      "affiliations": [
        "Karolinska Institutet, Department of Medicine Solna, Division of Clinical Epidemiology, Stockholm, Sweden"
      ],
      "name": "Annica Dominicus"
    },
    {
      "affiliations": [
        "Karolinska Institutet, Department of Medicine Solna, Division of Rheumatology, Stockholm, Sweden"
      ],
      "name": "Jelena Colic"
    },
    {
      "affiliations": [
        "Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden",
        "Department of Medical Specialties, Danderyd Hospital, Stockholm, Sweden"
      ],
      "name": "Jacob Widaeus"
    },
    {
      "affiliations": [
        "Karolinska Institutet, Department of Medicine Solna, Division of Rheumatology, Stockholm, Sweden"
      ],
      "name": "Hevgin Alagündüz"
    },
    {
      "affiliations": [
        "Department of Medicine Solna, Division of Rheumatology, Karolinska Institutet and Rheumatology, KUH, Stockholm, Sweden"
      ],
      "name": "Elisabet Svenungsson"
    },
    {
      "affiliations": [
        "Karolinska Institutet, Department of Medicine Solna, Division of Clinical Epidemiology, Stockholm, Sweden"
      ],
      "name": "Elizabeth Arkema"
    },
    {
      "affiliations": [
        "Karolinska Institutet, Department of Medicine Solna, Division of Rheumatology, Stockholm, Sweden",
        "Department of Hematology, Karolinska University Hospital, Stockholm, Sweden"
      ],
      "name": "Maria Bruzelius"
    },
    {
      "affiliations": [
        "Department of Medicine Solna, Division of Rheumatology, Karolinska Institutet and Rheumatology, KUH, Stockholm, Sweden"
      ],
      "name": "Aleksandra Antovic"
    }
  ],
  "title": "PO:01:020 High burden of concomitant autoimmune diseases in antiphospholipid syndrome: to assess the prevalence and 5-year incidence of autoimmune diseases (ADs) in a swedish population-based cohort study",
  "uid": "60e82e27-5241-5c9b-85fd-9116d31fd5ce"
}