{
  "abstract": "Objectives Lupus nephritis (LN) is more common in Black than in White ethnic groups. High risk apolipoprotein L1 (APOL1) genetic variants are associated with end-stage kidney disease among people with systemic lupus erythematosus (SLE) of African ancestry. However, the relationship between APOL1 high risk genotypes (HRGs) and LN incidence remains unclear. We aimed to investigate the association of APOL1 HRGs with LN occurrence and subsequent kidney impairment in patients of African ancestry with SLE in the United Kingdom.Methods We conducted a case-control study of 92 adults with SLE of African ancestry, including participants with biopsy-proven LN (cases N=46) and without LN (controls N=46; age and sex-matched 1:1). Conditional logistic regression estimated the odds ratio (OR) of LN by APOL1 status (HRGs: two risk alleles versus low-risk genotypes: zero or one risk allele). Trajectories of estimated glomerular filtration rates (eGFR) and urine protein:creatinine (uPCR) were modelled over time in participants with LN by number of APOL1 risk alleles, using mixed-effects models with restricted cubic splines.Results Frequencies of APOL1 HRGs were 30% in cases and 15% in controls ( figure 1). APOL1 HRGs were associated with increased odds of LN (OR 3.27, 95% CI 1.02-10.53). Those with no risk alleles had a decline in mean eGFR at LN diagnosis, which recovered over time (slope +8.2mls/min/1.73m2/year, 95% CI -1.3 to 17.7, years 1-4 after diagnosis) compared to one (-3.1mls/min/1.73m2/year, 95% CI -18.6 to 12.3) and two risk alleles (-7.0mls/min/1.73m2/year, 95% CI -21.7 to 7.7).Abstract PT2:05 Figure 1Conclusions APOL1 HRGs were associated with LN incidence, with trends suggesting progression of CKD according to the number of risk alleles. This may contribute to the high burden of LN among those of recent African ancestry. APOL1 genotyping could help stratify risk of developing LN and guide precision treatment strategies in this disproportionately affected and underserved population.",
  "authors": [
    {
      "affiliations": [
        "King’s College London, London, UK"
      ],
      "name": "Samir Patel"
    },
    {
      "affiliations": [
        "King’s College London, London, UK"
      ],
      "name": "Hadi Rabee"
    },
    {
      "affiliations": [
        "King’s College London, London, UK"
      ],
      "name": "Amrita Ramnarine"
    },
    {
      "affiliations": [
        "King’s College London, London, UK"
      ],
      "name": "Dalvir Kular"
    },
    {
      "affiliations": [
        "King’s College London, London, UK"
      ],
      "name": "Evangelos Kougiouris"
    },
    {
      "affiliations": [
        "King’s College London, London, UK"
      ],
      "name": "Mark Russell"
    },
    {
      "affiliations": [
        "King’s College London, London, UK"
      ],
      "name": "Mohammad Al-Agil"
    },
    {
      "affiliations": [
        "King’s College London, London, UK"
      ],
      "name": "Maryam Adas"
    },
    {
      "affiliations": [
        "King’s College London, London, UK"
      ],
      "name": "Chris Wincup"
    },
    {
      "affiliations": [
        "King’s College London, London, UK"
      ],
      "name": "Jonathan Dick"
    },
    {
      "affiliations": [
        "King’s College London, London, UK"
      ],
      "name": "Sam Norton"
    },
    {
      "affiliations": [
        "King’s College London, London, UK"
      ],
      "name": "James Galloway"
    },
    {
      "affiliations": [
        "King’s College London, London, UK"
      ],
      "name": "Patrick Gordon"
    },
    {
      "affiliations": [
        "King’s College London, London, UK"
      ],
      "name": "Kate Bramham"
    }
  ],
  "title": "PT2:05 High risk apolipoprotein L1 genetic variants are associated with the occurrence of lupus nephritis: a case-control study",
  "uid": "55a2bf85-16ab-5510-8cc5-d5fd60dd3c43"
}