{
  "abstract": "Objectives Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease associated with a high risk of developing cardiovascular (CV) events. 1 The aim of this study is to analyse the performance of the main CV risk calculators, Framingham Score (FRS), QRISK3, and SLECRE,2 in predicting CV events at 10 years.Methods We enrolled 82 SLE patients, with a minimum follow-up of 10 years and complete data on SLE features, disease activity (as SLEDAI-2K) and CV risk factors. Clinical and serological data were collected from clinical charts. CV risks were calculated at the CV event (at the last follow-up for controls) and 10 years before. A p-value lower than or equal to 0.05 was considered statistically significant.Results Figure 1 shows demographic, CV risk data of the 82 patients, and the distribution of 27 CV events.CV events were associated with male sex (p: 0.01), longer SLE history (p: 0.014), and higher values of SLEDAI-2K at the event and 10 years before (p: 0.0023 and p: 0.0003, respectively). No differences in autoantibodies’ or clinical data were detected between groups.Considering risk factors, higher systolic pressure (p: 0.007) and chronic kidney disease (p<0.0001) were the only items associated with CV events, 10 years before.Stratifying patients in low (<10%), intermediate (11-20%), and high (>20%) CV risk, only SLECRE >20%, assessed 10 years before the CV event or before the last follow-up, was significantly associated with the CV event development at 10 years [OR: 5 (IC 95%: 1.8–13.6); p: 0.002]. FRS and QRISK3 stratification did not differ between CV event development and controls.Only anti-beta2glycoprotein-I, anti-dsDNA antibodies, lupus nephritis, and complement reduction were associated with SLECRE >10%, assessed 10 years before the last available, independently from CV event occurrence.Abstract PO:03:068 Table 1Demographic and CV risk data of the 82 SLE patientsAbstract PO:03:068 Figure 1Distribution of 27 CV eventsConclusions SLECRE calculator demonstrated the best performance in identifying patients at risk to develop CV events at 10 years, compared with Framingham Score and QRISK3. This is due to the inclusion of differently weighted items, such as traditional CV risk factors, disease activity and lupus anticoagulant.References Schoenfeld SR, et al. Semin Arthritis Rheum. 2013. Sivakumaran J, et al. Lupus Sci Med. 2021.",
  "authors": [
    {
      "affiliations": [
        "‘Spedali Civili’ of Brescia, Brescia, Italy",
        "University of Brescia, Brescia, Italy"
      ],
      "name": "Francesca Vignoni"
    },
    {
      "affiliations": [
        "University of Brescia, Brescia, Italy"
      ],
      "name": "Serena Iodice"
    },
    {
      "affiliations": [
        "University of Brescia, Brescia, Italy"
      ],
      "name": "Cesare Tomasi"
    },
    {
      "affiliations": [
        "‘Spedali Civili’ of Brescia, Brescia, Italy",
        "University of Brescia, Brescia, Italy"
      ],
      "name": "Chiara Orlandi"
    },
    {
      "affiliations": [
        "‘Spedali Civili’ of Brescia, Brescia, Italy"
      ],
      "name": "Eleonora Pedretti"
    },
    {
      "affiliations": [
        "University of Brescia, Brescia, Italy"
      ],
      "name": "Micaela Fredi"
    },
    {
      "affiliations": [
        "‘Spedali Civili’ of Brescia, Brescia, Italy",
        "University of Brescia, Brescia, Italy"
      ],
      "name": "Franco Franceschini"
    },
    {
      "affiliations": [
        "‘Spedali Civili’ of Brescia, Brescia, Italy",
        "University of Brescia, Brescia, Italy"
      ],
      "name": "Ilaria Cavazzana"
    }
  ],
  "title": "PO:03:068 Cardiovascular risk in SLE patients: comparative analysis among framingham score, QRISK3, and SLECRE",
  "uid": "4325e15f-d243-59a9-8b0f-2c862ca1d86c"
}