{
  "abstract": "Objectives Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a heterogeneous clinical spectrum. Gastrointestinal (GI) involvement is uncommon but clinically relevant, with multifactorial etiology and diagnostic challenges.Objective To describe clinical characteristics and identify factors associated with gastrointestinal involvement in SLEMethods We conducted a cross-sectional study of 240 patients fulfilling 2019 EULAR/ACR criteria at a tertiary university hospital (Hospital A). Eleven patients (4.6%) with GI manifestations were compared with 229 without GI involvement using bivariate and multivariate analyses. In a secondary analysis, seven additional GI cases from a second centre (Hospital B) were added, yielding 18 cases and 222 matched controls, adjusted for centre effect; sensitivity analyses confirmed robustness.Results In the primary analysis (Hospital A), 11 patients (4.6%) presented GI manifestations. Compared with 229 controls without GI involvement, these patients showed higher SLEDAI- 2K scores (mean ± SD: 3.1 ± 3.0 vs. 1.6 ± 2.4; p = 0.04) and more accumulated organ damage (72.7% vs. 38.4%; p = 0.03). GI cases had lower prevalence of nephritis (0% vs. 28.6%; p = 0.04) but higher rates of neurological involvement (27.3% vs. 6.1%; p = 0.01). Comorbid hypertension (72.7% vs. 38.9%; p = 0.03) and dyslipidemia (63.6% vs. 27.9%; p = 0.02) were also more frequent in GI cases ( table 1).In the exploratory pooled analysis (18 GI cases, 222 controls), results were generally consistent. GI patients were older (mean 59 ± 13.5 vs. 51 ± 13.5 years; p = 0.02) and had higher prevalence of hypertension (72.2% vs. 38.9%; p = 0.01) and dyslipidemia (77.8% vs. 27.9%; p = 0.001) (table 1). 16 out of 18 patients (89%) presented with autoimmune/lupus hepatitis, while the remaining 2 cases corresponded to mesenteric vasculitis.In multivariable logistic regression, GI involvement was independently associated with dyslipidemia and inversely associated with a history of nephritis (table 2).Abstract PO:04:098 Table 1–2Conclusions Gastrointestinal manifestations in SLE are uncommon, occurring in less than 5% of our cohort. In most cases, they presented as autoimmune hepatitis. GI involvement was associated with older age and a higher prevalence of cardiometabolic comorbidities, while prior nephritis appeared to be protective.",
  "authors": [
    {
      "affiliations": [
        "University Hospital Insular de Gran Canaria, Las Palmas, Spain"
      ],
      "name": "Beatriz Tejera Segura"
    },
    {
      "affiliations": [
        "University Hospital Insular de Gran Canaria, Las Palmas, Spain"
      ],
      "name": "Judith Hernández Sánchez"
    },
    {
      "affiliations": [
        "University Hospital Dr Negrín de Gran Canaria, Las Palmas, Spain"
      ],
      "name": "Jesús M Cerdeña Corrales"
    },
    {
      "affiliations": [
        "University Hospital Insular de Gran Canaria, Las Palmas, Spain"
      ],
      "name": "Luis Bausá Gimeno"
    },
    {
      "affiliations": [
        "University Hospital Insular de Gran Canaria, Las Palmas, Spain"
      ],
      "name": "Patricia González Terrats"
    },
    {
      "affiliations": [
        "University Hospital Insular de Gran Canaria, Las Palmas, Spain"
      ],
      "name": "Candela Zavala"
    },
    {
      "affiliations": [
        "University Hospital Dr Negrín de Gran Canaria, Las Palmas, Spain"
      ],
      "name": "Iñigo Rúa-Figueroa De Larrinoa"
    },
    {
      "affiliations": [
        "University Hospital Dr Negrín de Gran Canaria, Las Palmas, Spain"
      ],
      "name": "Francisco Rubiño Juárez"
    }
  ],
  "title": "PO:04:098 Gastrointestinal manifestations in SLE: prevalence, clinical features, and associated factors in a multicentre cohort",
  "uid": "3764ec6d-529c-545d-a8af-b265c6c8fd77"
}