{
  "abstract": "Objectives SMILES is a multicenter Spanish endeavor focused on a comprehensive molecular characterization of a cohort of lupus patients using transcriptomic, single cell sequencing and microbiome analysis. In this initial report we used baseline clinical data to assess associations between lifestyle features and quality of life (QoL) of these patients.Methods Forty-one Rheumatology departments across Spain participated. We enrolled adults (>=18 years) fulfilling 1997 or 2019 ACR classification criteria for SLE. Evaluation included: medical record review, clinical assessment, blood, urine, fecal and cutaneous microbioma samples and cutaneous biopsies. SLEDAI 2K and BILAG indices for activity evaluation and SLICC disease index (SDI) for damage were used. Lifestyle variables were: smoking, alcohol intake, university education and regular physical exercise. QoL was measured with the LupusQoL across eight domains: physical health, pain, planning, intimate relationships, burden to others, emotional health, body image, and fatigue. Associations were assessed using linear regression models, fit separately for each LupusQoL score (outcome) and lifestyle factor (predictor).Results A total of 220 patients (90% women; mean age 45.8 ± 12.6 years; mean disease duration 12.0 ± 9.8 years) were included. Smoking was significantly associated with poorer results in all LupusQoL domains, whereas university education and regular physical exercise were associated with better results in the large majority of domains ( table 1). Alcohol intake was associated with better QoL; mot drinkers reported only occasional consumption, consistent with a social pattern and correlated with having university studies. No differences were observed for disease activity indices, while smoking was associated with higher damage (SDI, p = 0.05).Abstract PO:13:343 Table 1P values of associations between life-style features and LQoL domains using liner regression modelsConclusions Lifestyle factors show robust associations with QoL in SLE: smoking correlates with poorer QoL, whereas university education and regular physical exercise correlate with better QoL; occasional alcohol intake also correlates with better QoL, likely reflecting social/educational context. Causality cannot be inferred from cross-sectional data; however, from a clinical standpoint these findings support reinforcing smoking cessation and promoting physical activity and health education as part of holistic SLE care.",
  "authors": [
    {
      "affiliations": [
        "Hospital Universitario Araba, Rheumatology, Vitoria, Spain"
      ],
      "name": "Jaime Calvo-Alén"
    },
    {
      "affiliations": [
        "Hospital Universitario de Jerez de la Frontera, Rheumatology, Cáidz, Spain"
      ],
      "name": "Miriam Gandia-Martínez"
    },
    {
      "affiliations": [
        "Hospital Universitario de Jerez de la Frontera, Rheumatology, Cáidz, Spain"
      ],
      "name": "Raúl Menor-Almagro"
    },
    {
      "affiliations": [
        "Complejo Hospitalario Universitario de A Coruña, Rheumatology, A Coruña, Spain"
      ],
      "name": "Mercedes Freire-González"
    },
    {
      "affiliations": [
        "Complejo Hospitalario Universitario de A Coruña, Rheumatology, A Coruña, Spain"
      ],
      "name": "Guillermo González-Arribas"
    },
    {
      "affiliations": [
        "Hospital Universitari Vall d´Hebron, Rheumatoloy, Barcelona, Spain",
        "Vall d´Hebron Hospital Research Institute, Lupus-Rheumatology, Barcelona, Spain"
      ],
      "name": "Josefina Cortés-Hernández"
    },
    {
      "affiliations": [
        "Vall d´Hebron Hospital Research Institute, Lupus-Rheumatology, Barcelona, Spain"
      ],
      "name": "María Royo-López"
    },
    {
      "affiliations": [
        "Hospital Universitario de Canarias, Rheumatology, Tenerife, Spain"
      ],
      "name": "María García-González"
    },
    {
      "affiliations": [
        "Hospital Universitario de Canarias, Rheumatology, Tenerife, Spain"
      ],
      "name": "Marta Hernández-Díaz"
    },
    {
      "affiliations": [
        "Hospital Universitari Parc Taulí, Rheumatology, Sabadell, Spain"
      ],
      "name": "Silvia García-Cirera"
    },
    {
      "affiliations": [
        "Hospital Universitari Parc Taulí, Rheumatology, Sabadell, Spain"
      ],
      "name": "Vera Ortiz-Santamaría"
    },
    {
      "affiliations": [
        "Hospital Universitari Son Llàtzer, Rheumatology, Palma, Spain"
      ],
      "name": "Regina Faré-García"
    },
    {
      "affiliations": [
        "Hospital Universitari Son Llàtzer, Dermatology, Palma, Spain"
      ],
      "name": "Ignacio Torné-Gutiérrez"
    },
    {
      "affiliations": [
        "Hospital Universitario Araba, Rheumatology, Vitoria, Spain"
      ],
      "name": "Juan R De Dios"
    },
    {
      "affiliations": [
        "Hospital Universitario Araba, Rheumatology, Vitoria, Spain"
      ],
      "name": "Carmen García-Gómez"
    },
    {
      "affiliations": [
        "Hospital Universitario Ramón y Cajal, Rheumatology, Madrid, Spain"
      ],
      "name": "Sandra Garrote-Corral"
    },
    {
      "affiliations": [
        "Hospital Universitario Ramón y Cajal, Dermatology, Madrid, Spain"
      ],
      "name": "Elena De Las Heras-Alonso"
    },
    {
      "affiliations": [
        "Hospital Universitari de Bellvitge, Rheumatology, Hospitalet de Llobregat, Spain"
      ],
      "name": "Javier Narváez-García"
    },
    {
      "affiliations": [
        "Hospital Universitari de Bellvitge, Rheumatology, Hospitalet de Llobregat, Spain"
      ],
      "name": "Paola Vidal-Montal"
    },
    {
      "affiliations": [
        "Hospital Universitario Dr. Peset, Rheumatology, Valencia, Spain"
      ],
      "name": "Carlos Valera-Ribera"
    },
    {
      "affiliations": [
        "Hospital Universitario Dr. Peset, Rheumatology, Valencia, Spain"
      ],
      "name": "Alida Taberner-Cortés"
    },
    {
      "affiliations": [
        "Complejo Asistencial Universitario de León, Rheumatology, León, Spain"
      ],
      "name": "Miriam Retuerto-Guerrero"
    },
    {
      "affiliations": [
        "Complejo Asistencial Universitario de León, Rheumatology, León, Spain"
      ],
      "name": "Clara Moriano-Morales"
    },
    {
      "affiliations": [
        "Hospital Universitario de Cabueñes, Rheumatology, Gijón, Spain"
      ],
      "name": "Anahy Mª Brandy-García"
    },
    {
      "affiliations": [
        "Hospital Universitario de Cabueñes, Dermatology, Gijón, Spain"
      ],
      "name": "Rubén Barros-Tornay’s"
    },
    {
      "affiliations": [
        "Hospital Universitario Virgen Macarena, Rheumatology, Sevilla, Spain"
      ],
      "name": "Virginia Moreira-Navarrete"
    },
    {
      "affiliations": [
        "Hospital Universitario Virgen Macarena, Rheumatology, Sevilla, Spain"
      ],
      "name": "Carmen Domínguez-Quesada"
    },
    {
      "affiliations": [
        "Hospital Universitario Puerta de Hierro, Rheumatology, Madrid, Spain"
      ],
      "name": "Blanca García-Magallón"
    },
    {
      "affiliations": [
        "Hospital Universitario Puerta de Hierro, Rheumatology, Madrid, Spain"
      ],
      "name": "Carolina Merino-Argumánez"
    },
    {
      "affiliations": [
        "Hospital Clínic de Barcelona, Rheumatology, Barcelona, Spain"
      ],
      "name": "José A Gómez-Puerta"
    },
    {
      "affiliations": [
        "Hospital Clínic de Barcelona, Rheumatology, Barcelona, Spain"
      ],
      "name": "Juan C Sarmiento"
    },
    {
      "affiliations": [
        "Hospital de Mérida, Rheumatology, Mérida, Spain"
      ],
      "name": "Sara María Rojas-Herrera"
    },
    {
      "affiliations": [
        "Hospital de Mérida, Rheumatology, Mérida, Spain"
      ],
      "name": "Cristina Arciniega-Larios"
    },
    {
      "affiliations": [
        "Hospital General Universitario de Alicante Dr. Balmis, Rheumatology. Universidad Miguel Hernández, Alicante, Spain",
        "ISABIAL, Alicante, Spain"
      ],
      "name": "Paloma Vela-Casasempere"
    },
    {
      "affiliations": [
        "ISABIAL, Alicante, Spain"
      ],
      "name": "Rocío Caño-Alameda"
    },
    {
      "affiliations": [
        "Hospital Universitario Central Asturias, Rheumatology, Asturias, Spain"
      ],
      "name": "Ignacio Braña-Abascal"
    },
    {
      "affiliations": [
        "Hospital Universitario Central Asturias, Rheumatology, Asturias, Spain"
      ],
      "name": "Estefanía Pardo-Campo"
    },
    {
      "affiliations": [
        "Hospital Universitario de Gran Canaria Doctor Negrín, Rheumatology, Las Palmas de Gran Canaria, Spain"
      ],
      "name": "Íñigo Rua-Figueroa"
    },
    {
      "affiliations": [
        "Hospital Universitario de Gran Canaria Doctor Negrín, Rheumatology, Las Palmas de Gran Canaria, Spain"
      ],
      "name": "Jesús Cerdeña-Corrales"
    },
    {
      "affiliations": [
        "Hospital Clínico Universitario de Salamanca, Rheumatology, Salamanca, Spain"
      ],
      "name": "Olga Compán-Fernández"
    },
    {
      "affiliations": [
        "Hospital Clínico Universitario de Salamanca, Rheumatology, Salamanca, Spain",
        "Hospital Universitario Marina Baixa, Rheumatology, Villajoyosa, Spain"
      ],
      "name": "Marta Ibáñez-Martínez"
    },
    {
      "affiliations": [
        "Hospital Universitario 12 de Octubre, Rheumatology, Madrid, Spain"
      ],
      "name": "María Galindo-Izquierdo"
    },
    {
      "affiliations": [
        "Hospital Universitario 12 de Octubre, Rheumatology, Madrid, Spain"
      ],
      "name": "Raquel Zas-Vaamonde"
    },
    {
      "affiliations": [
        "Hospital Regional Universitario de Málaga, Rheumatology, Málaga, Spain"
      ],
      "name": "Sara Manrique-Arija"
    },
    {
      "affiliations": [
        "Hospital Regional Universitario de Málaga, Rheumatology, Málaga, Spain"
      ],
      "name": "Laura Cano-García"
    },
    {
      "affiliations": [
        "Complejo Hospitalario Universitario de Santiago, Rheumatology, Santiago, Spain"
      ],
      "name": "Eva María Pérez-Pampín"
    },
    {
      "affiliations": [
        "Hospital Universitario Marqués de Valdecilla, Rheumatology, Santander, Spain"
      ],
      "name": "Ricardo Blanco-Alonso"
    },
    {
      "affiliations": [
        "Hospital Universitari Mútua de Terrassa, Rheumatology, Terrassa, Spain"
      ],
      "name": "Elena Riera-Alonso"
    },
    {
      "affiliations": [
        "Hospital Universitario Reina Sofía, Rheumatology, Córdoba, Spain"
      ],
      "name": "Rafaela Ortega-Castro"
    },
    {
      "affiliations": [
        "Hospital Universitario Sierrallana, Rheumatology. IDIVAL. Torrelavega, Spain"
      ],
      "name": "Elena Aurreocoechea-Aguinaga"
    },
    {
      "affiliations": [
        "Hospital Universitari Germans Trias i Pujol, Rheumatology, Badalona, Spain"
      ],
      "name": "Anne Riveros-Frutos"
    },
    {
      "affiliations": [
        "Hospital Universitario La Paz, Rheumatology, Madrid, Spain"
      ],
      "name": "Cristina Bohórquez-Heras"
    },
    {
      "affiliations": [
        "Hospital universitario de la Princesa. IIS-Princesa, Rheumatology, Madrid, Spain"
      ],
      "name": "Eva Tomero-Muriel"
    },
    {
      "affiliations": [
        "Hospital Universitario Marina Baixa, Rheumatology, Villajoyosa, Spain"
      ],
      "name": "Jose Miguel Senabre-Gallego"
    },
    {
      "affiliations": [
        "Complejo Hospitalario Universitario de Pontevedra, Rheumatology, Pontevedra, Spain"
      ],
      "name": "Lucía Silva-Fernández"
    },
    {
      "affiliations": [
        "Hospital Universitario Virgen de la Arrixaca, Rheumatology, Murcia, Spain"
      ],
      "name": "Jenifer Esther Ruiz-Sara"
    },
    {
      "affiliations": [
        "Hospital Universitario Gregorio Marañón, Rheumatology, Madrid, Spain"
      ],
      "name": "Pablo Rodríguez-Merlo"
    },
    {
      "affiliations": [
        "Hospital General Universitario de Valencia, Rheumatology, Valencia, Spain"
      ],
      "name": "Mireia Sanmartín-Martínez"
    },
    {
      "affiliations": [
        "Hospital Universitario La Fe, Rheumatology, Valencia, Spain"
      ],
      "name": "Jose Andrés Román-Ivorra"
    },
    {
      "affiliations": [
        "Hospital Universitari Moisès Broggi, Rheumatology, Sant Joan Despí, Spain"
      ],
      "name": "Sergio Heredia-Martín"
    },
    {
      "affiliations": [
        "Hospital Universitario de Donostia, Rheumatology, Donostia, Spain"
      ],
      "name": "Joaquín Belzunegui-Otano"
    },
    {
      "affiliations": [
        "Hospital Universitario Virgen de la Concha, Rheumatology, Zamora, Spain"
      ],
      "name": "Ruth López-González"
    },
    {
      "affiliations": [
        "Hospital Universitario Príncipe de Asturias, Rheumatology, Madrid, Spain"
      ],
      "name": "Lucía Ruiz-Gutiérrez"
    },
    {
      "affiliations": [
        "Hospital del Mar, Rheumatology, Barcelona, Spain"
      ],
      "name": "Tarek Salman-Monte"
    },
    {
      "affiliations": [
        "Imidomics, Inc, Barcelona, Spain"
      ],
      "name": "Sergio H Martínez-Mateu"
    },
    {
      "affiliations": [
        "Imidomics, Inc, Barcelona, Spain"
      ],
      "name": "Clara Fermoselle-Pérez"
    },
    {
      "affiliations": [
        "Hospital Clínic de Barcelona, Rheumatology, Barcelona, Spain"
      ],
      "name": "Juan D Cañete"
    },
    {
      "affiliations": [
        "Imidomics, Inc, Barcelona, Spain"
      ],
      "name": "Sara Marsal"
    }
  ],
  "title": "PO:13:343 Associations of lifestyle features with quality of life in patients with systemic lupus erythematosus. Results from baseline clinical data of the multi-omic multi-institutional SMILES study",
  "uid": "35e819f1-07e0-5cfa-b9b5-7001c2178070"
}