{
  "abstract": "Objectives This study aims to evaluate capillaroscopic abnormalities in systemic lupus erythematosus (SLE) patients versus healthy controls and to explore correlations between microvascular changes and clinical or immunological features. It also supports the diagnostic and prognostic value of nailfold videocapillaroscopy (NVC) in SLE, given prior evidence of heterogeneous microvascular involvement.Methods This observational, case-control study included 105 SLE patients and 59 healthy controls evaluated between January and June 2025. All participants underwent NVC performed by trained operators using standardized protocols. Capillaroscopic parameters assessed included average capillary density, presence of tortuous, dilated, and giant capillaries, neoangiogenesis, hemorrhages, and scleroderma or scleroderma-like pattern. Clinical data were collected through structured interviews and chart reviews, including vascular manifestations (acrocyanosis, Raynaud’s phenomenon (RP), digital ulcers), smoking status, beta-blocker use, and autoantibody profiles. Statistical analyses included chi-square, t-tests, Fisher’s exact test for categorical variables, and odds ratios with 95% confidence intervals to explore associations between capillaroscopic and clinical-immunological variables.Results Compared to controls, SLE patients more frequently presented with RP (p=0.001) and acrocyanosis (p=0.003), while smoking habits did not differ. Capillaroscopy revealed significantly lower capillary density (p<0.001) and higher frequencies of tortuous (p=0.043), dilated (p=0.001), and giant capillaries (p=0.014). Neoangiogenesis (p<0.001) and scleroderma-like patterns (p=0.027) were exclusive to SLE patients. Within the SLE cohort, acrocyanosis was associated with giant capillaries (p=0.030), while RP correlated with dilated (p=0.007), giant (p=0.045), and scleroderma-like patterns (p=0.013). Vasculitis or digital ulcers were linked to capillary density < 7/mm (p=0.025), giant capillaries (p=0.002), and scleroderma-like patterns (p=0.040). Anti-Sm positivity was associated with neoangiogenesis (p=0.043) and dilated capillaries (p=0.012), while anti-U1RNP positivity correlated with neoangiogenesis (p=0.043).Abstract PO:12:314 Table 1Comparision of anamnestic data and capillaroscopic features between cases and controlsAbstract PO:12:314 Table 2Association between capillaroscopic findings and clinical-immunological featuresConclusions SLE patients exhibit distinct nailfold capillaroscopic abnormalities compared to healthy controls. Specific findings, such as neoangiogenesis, giant capillaries, and scleroderma-like patterns, are significantly associated with vascular symptoms and autoantibody profiles. These results support NVC as a non-invasive tool for assessing microvascular involvement, disease monitoring, and clinical stratification in SLE.",
  "authors": [
    {
      "affiliations": [
        "Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, ERN-ReCONNET Center, Brescia, Italy",
        "Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy"
      ],
      "name": "Chiara Orlandi"
    },
    {
      "affiliations": [
        "Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy"
      ],
      "name": "Alessia Loda"
    },
    {
      "affiliations": [
        "Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, ERN-ReCONNET Center, Brescia, Italy",
        "Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy"
      ],
      "name": "Cesare Tomasi"
    },
    {
      "affiliations": [
        "Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, ERN-ReCONNET Center, Brescia, Italy",
        "Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy"
      ],
      "name": "Silvia Ebe Lucia Della Pina"
    },
    {
      "affiliations": [
        "Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, ERN-ReCONNET Center, Brescia, Italy",
        "Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy"
      ],
      "name": "Claudia Barison"
    },
    {
      "affiliations": [
        "Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, ERN-ReCONNET Center, Brescia, Italy"
      ],
      "name": "Cecilia Nalli"
    },
    {
      "affiliations": [
        "Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, ERN-ReCONNET Center, Brescia, Italy",
        "Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy"
      ],
      "name": "Ilaria Cavazzana"
    },
    {
      "affiliations": [
        "Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, ERN-ReCONNET Center, Brescia, Italy",
        "Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy"
      ],
      "name": "Micaela Fredi"
    },
    {
      "affiliations": [
        "Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, ERN-ReCONNET Center, Brescia, Italy",
        "Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy"
      ],
      "name": "Franco Franceschini"
    }
  ],
  "title": "PO:12:314 Nailfold capillaroscopic abnormalities in systemic lupus erythematosus: comparison with healthy controls and clinical–immunological correlations – preliminary data",
  "uid": "34ab910e-4376-5fe4-8b74-0dbd73c55183"
}