{
  "abstract": "Objectives Late-onset systemic lupus erythematosus (LO-SLE) is a less common form of the disease, characterised by a higher burden of comorbidities and less frequent organ involvement. Our objective is to analyse the demographic, clinical and therapeutic characteristics of patients with LO-SLE in relation to other patients.Methods A cross-sectional observational study of SLE patients followed from January 2012 to May 2025, categorised into two groups according to age at diagnosis: younger than 50 years (not LO-SLE) and older than 50 years (LO-SLE). Demographic, clinical, analytical and therapeutic variables were collected from the patients‘ electronic medical records.Results A total of 302 patients (90.70% women) were included, divided into 231 not LO-SLE and 71 LO-SLE ( table 1). The follow-up time was significantly shorter in the LO-SLE group (p<0.001).In terms of comorbidities, the LO-SLE group had a higher proportion of osteoporosis (p<0.001), neoplasms (p<0.001), high blood pressure (p=0.001) and dyslipidemia (p=0.025). Numerically, we found a higher proportion of lupus nephropathy in the non-LO-SLE group (16% vs 6%), but the results were not statistically significant.No differences were found in the clinical manifestations at onset, the autoimmunity profile, or the treatments administered. However, a trend towards a higher presence of anti-Ro/La antibodies (p=0.074) and Sjögren’s syndrome (p=0.093) was observed in patients with LO-SLE.Abstract PO:04:099 Table 1Characteristics of the study populationConclusions 23.5% of our SLE patients were diagnosed after the age of 50 and have a significantly shorter follow-up time. These patients have a higher proportion of comorbidities (osteoporosis, neoplasms, high blood pressure and dyslipidemia), probably due to their age.In this real-life study, no differences were found in the clinical manifestations at onset, the autoimmunity profile, or the treatments administered compared to patients without LO-SLE.",
  "authors": [
    {
      "affiliations": [
        "Hospital Universitario y Politécnico La Fe, Valencia, Spain"
      ],
      "name": "Miguel Simeó Vinaixa"
    },
    {
      "affiliations": [
        "Hospital Universitario y Politécnico La Fe, Valencia, Spain"
      ],
      "name": "Belén Villanueva Mañes"
    },
    {
      "affiliations": [
        "Instituto de Investigación Sanitario La Fe, Valencia, Spain"
      ],
      "name": "Elena Grau García"
    },
    {
      "affiliations": [
        "Hospital Universitario y Politécnico La Fe, Valencia, Spain"
      ],
      "name": "Pablo Francisco Muñoz-Martínez"
    },
    {
      "affiliations": [
        "Hospital Arnau de Vilanova, Valencia, Spain"
      ],
      "name": "Laura Mas Sánchez"
    },
    {
      "affiliations": [
        "Hospital Universitario y Politécnico La Fe, Valencia, Spain"
      ],
      "name": "Samuel Leal Rodríguez"
    },
    {
      "affiliations": [
        "Hospital Universitario y Politécnico La Fe, Valencia, Spain"
      ],
      "name": "Meritxell Fernández Matilla"
    },
    {
      "affiliations": [
        "Hospital Universitario y Politécnico La Fe, Valencia, Spain"
      ],
      "name": "Daniel Ramos Castro"
    },
    {
      "affiliations": [
        "Hospital Universitario y Politécnico La Fe, Valencia, Spain"
      ],
      "name": "Alba María Torrat Noves"
    },
    {
      "affiliations": [
        "Hospital Universitario y Politécnico La Fe, Valencia, Spain"
      ],
      "name": "Iago Alcántara Álvarez"
    },
    {
      "affiliations": [
        "Hospital Universitario y Politécnico La Fe, Valencia, Spain"
      ],
      "name": "Andrés Pérez Hurtado"
    },
    {
      "affiliations": [
        "Hospital Universitario y Politécnico La Fe, Valencia, Spain"
      ],
      "name": "Patricia Antón Enguídanos"
    },
    {
      "affiliations": [
        "Hospital Universitario y Politécnico La Fe, Valencia, Spain"
      ],
      "name": "Belén Díaz Mora"
    },
    {
      "affiliations": [
        "Hospital Universitario y Politécnico La Fe, Valencia, Spain"
      ],
      "name": "José Andrés Román Ivorra"
    }
  ],
  "title": "PO:04:099 Late-onset SLE in real-world practice: higher comorbidity burden with comparable clinical, serologic, and treatment profiles",
  "uid": "2d420ec3-3b61-5b68-af01-b6462a9c550f"
}