{
  "abstract": "Objectives Autoantibodies serve as key diagnostic and classification criteria for systemic lupus erythematosus(SLE).These include antinuclear antibodies, anti-dsDNA and anti-Sm, together with other antibodies such as antiphospholipid(aPL) or complement proteinsC3 and C4. By contrast, although antibodies that recognize RNA-binding proteins and anti-Cq1 are also common in patients with SLE, they are not part of the classification criteria and have a wider distribution among diseases. In addition to serving as markers of disease, some autoantibodies can have a direct role in the clinical manifestations of SLE.Methods This observational retrospective-prospective study included 140 patients (88% women, median aged 34[26;41]years (median [interquartile range 25;75%]), with SLE(SLICC 2012) attending a routine visit at our Clinic. Baseline demographics, disease characteristic, organ system involvement/damage were analysed descriptively according to SLEDAI-2k,SDI.Results The median disease duration was 3,4 [0,4;12,0]years, SLEDAI-2k at the time of inclusion–6,5 [4,0;10,5]score, SDI–0 [0;2]score.An increase of anti-C1q is associated with high disease activity, criterion manifestations of SLE: arthritis/arthralgia, LN, serositis, hemolytic anemia, positive anti-dsDNA, anti-Sm, hypocomplementemia and non-criteria: lymphadenopathy and cryoglobulinemia.Positive anti-Ro/SSA are more common in patients with skin lesions as the first symptom of the disease and are associated with subacute cutaneous lupus erythematosus, concomitant Sjögren’s syndrome(SS), elevated anti-La/SSB levels, and cryoglobulinemia. They are not associated with SLE activity indicators. They are less frequently detected in Raynaud’s phenomenon and concomitant Antiphospholipid syndrome(APS).Positive anti-La/SSB were more common in patients with serositis, concomitant SS, and elevated anti-Ro/SSA levels. They were not associated with SLE activity indicators.Elevated rheumatoid factor(RF) levels were not associated with any manifestation of SLE, disease activity, or even with SS. In contrast, they were less common in patients with skin lesions throughout the disease course, especially with acute cutaneous lupus erythematosus, and in overweight patients.Positive anti-RNP-70 was associated with positive anti-Sm only.Conclusions The clinical heterogeneity of SLE may be based on antibody heterogeneity. Discoid lupus is associated with anti-Sm, subacute lupus–anti-Ro/SSA, lupus cutaneous generally is less common in patients of positive RF. Arthritis/arthralgia like LN are associated with anti-dsDNA, hypocomplementemia, anti-C1q and anti-Sm, serositis– with anti-C1q and anti-La/SSB, thrombocytopenia –with anti-Sm and aPL, cryoglobulinemia –with anti-C1q and anti-Ro/SSA.",
  "authors": [
    {
      "affiliations": [
        "V.A.Nasonova Research Institute of Rheumatology, Moscow, Russia"
      ],
      "name": "Tatiana Panafidina"
    },
    {
      "affiliations": [
        "V.A.Nasonova Research Institute of Rheumatology, Moscow, Russia"
      ],
      "name": "Tatiana Popkova"
    },
    {
      "affiliations": [
        "V.A.Nasonova Research Institute of Rheumatology, Moscow, Russia"
      ],
      "name": "Anastasiia Shumilova"
    },
    {
      "affiliations": [
        "V.A.Nasonova Research Institute of Rheumatology, Moscow, Russia"
      ],
      "name": "Yulia Gorbunova"
    },
    {
      "affiliations": [
        "V.A.Nasonova Research Institute of Rheumatology, Moscow, Russia"
      ],
      "name": "Liubov Kondrateva"
    },
    {
      "affiliations": [
        "V.A.Nasonova Research Institute of Rheumatology, Moscow, Russia"
      ],
      "name": "Anastasia Avdeeva"
    },
    {
      "affiliations": [
        "V.A.Nasonova Research Institute of Rheumatology, Moscow, Russia"
      ],
      "name": "Alexander Lila"
    }
  ],
  "title": "PO:02:039 The association between antibodies and clinical features in patients with systemic lupus erythematosus: non-criterial antibodies",
  "uid": "238d48ed-b4c4-592a-a589-a048cfd21d18"
}