{
  "abstract": "Objectives Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by dysregulated innate and adaptive immune responses. The Neutrophil-Lymphocyte Ratio (NLR) and Systemic Immune-Inflammation Index (SII) have recently emerged as integrated, readily accessible biomarkers that reflect the systemic inflammatory burden. The aim of this study was to evaluate the clinical utility of NLR and SII as biomarkers and to investigate their correlation with disease activity in SLE.Methods This study included 103 SLE patients and 30 healthy controls. The median age of the patient cohort was 38 years [30; 46], with a median disease duration of 10 years [4; 18]. Disease activity was assessed using the SLE Disease Activity Index 2000 (SLEDAI-2K). A complete blood count was performed using a SYSMEX XN 1000 hematology analyzer (Japan). NLR was calculated as the absolute neutrophil count divided by the absolute lymphocyte count. SII was calculated using the formula: (absolute neutrophil count × platelet count)/absolute lymphocyte count.Results NLR was significantly elevated in SLE patients compared to healthy controls (2.32 [1.48; 2.90] vs. 1.74 [1.41; 2.00], p = 0.008). An elevated NLR was significantly associated with moderate-to-very high disease activity (SLEDAI-2K greater than or equal to 6), with an odds ratio of 2.71 (95% CI: 1.16–6.36, p = 0.020). Furthermore, NLR demonstrated a positive correlation with the SLEDAI-2K score (rs = 0.275, p = 0.005), erythrocyte sedimentation rate (rs=0.207, p=0.006), and C-reactive protein (rs=0.355, p<0.0001). In contrast, the SII did not differ significantly between the SLE and control groups (469.61 [266.4; 758.81] vs. 414.97 [293.92; 503.84], p = 0.504) and showed no significant correlation with SLE disease activity. NLR and SII did not correlate with complement components and antibodies to double-stranded DNA.Conclusions Our findings confirm that NLR is significantly elevated in SLE patients compared to healthy controls and is independently associated with moderate-to-high disease activity. Conversely, SII did not differ significantly between the SLE and control groups.",
  "authors": [
    {
      "affiliations": [
        "V. A. Nasonova Research Institute of Rheumatology, Moscow, Russia"
      ],
      "name": "Kamila Nurbaeva"
    },
    {
      "affiliations": [
        "V. A. Nasonova Research Institute of Rheumatology, Moscow, Russia",
        "Russian Medical Academy of Continuing Professional Education, Department of Rheumatology, Moscow, Russia"
      ],
      "name": "Tatiana Reshetnyak"
    },
    {
      "affiliations": [
        "V. A. Nasonova Research Institute of Rheumatology, Moscow, Russia"
      ],
      "name": "Anastasiia Shumilova"
    },
    {
      "affiliations": [
        "V. A. Nasonova Research Institute of Rheumatology, Moscow, Russia",
        "Russian Medical Academy of Continuing Professional Education, Department of Rheumatology, Moscow, Russia"
      ],
      "name": "Aleksandr Lila"
    }
  ],
  "title": "PO:02:043 Comparative utility of NLR and SII as biomarkers of disease activity in systemic lupus erythematosus",
  "uid": "20cf18ff-33ae-5694-860d-fdb66e658fef"
}