{
  "abstract": "Objectives The concept of disease modification (DM) was recently introduced to improve the long-term care of patients (pts) with SLE. To claim DM ultimately requires delayed/prevented progression of organ damage beyond 5 years. The concept of DM is valuable for assessing ‘whether an intervention is on track for achieving DM at the 5-year mark,’ based on interim evaluations during the first 5 years. Latin American pts with SLE are prone to poorer outcomes, which are associated with disease severity and social determinants of health (SDH). We evaluated the prevalence of extrarenal DM in Latin American pts with SLE and examined SDH and treatment based on achievement of extrarenal DM.Methods GLADEL 2.0 included adults who fulfilled 1982/1997 ACR and/or 2012 SLICC classification criteria for SLE (43 centers; 10 Latin-American countries). Composite definition of DM for extrarenal SLE: (i) significant reduction in SLEDAI (>3 points), (ii) no severe flares, and (iii) <=10 mg/day prednisone for months 0–12 and <=5 mg/day prednisone-equivalent for years 2–5. Pts with complete data at baseline, 12, 24, 36, 48, and 60 months were analyzed.Results Among 1083 pts in the cohort, 709 had baseline data needed to fulfill DM criteria. Table 1 shows differences in demographics and SDH by extrarenal DM achievement groups over time. Although educational attainment varied between groups and genders at each time point, higher proportion of pts achieved DM among men compared to women at 36 and 48-months. The proportion of pts achieving DM criteria ranged between 16%–20% across time points (figure 1a). Figure 1b shows DM trajectories during follow-up. Medication exposure is depicted in figure 2. A higher number of pts achieving extrarenal DM at months 36 and 48 received cyclophosphamide.Abstract PT3:01 Figure 1–2Abstract PT3:01 Table 1Sociodemographics and their differences among patients with SLE who did and did not achieve extrarenal disease modification over timeConclusions Up to 20% of Latin American pts with SLE achieved extrarenal DM. The study highlights critical disparities; pts with lower educational attainment and women were less likely to achieve DM. Specific medication exposure may play a significant role in extrarenal DM achievement, particularly cyclophosphamide. These results underscore the importance of addressing SDH and tailoring treatment strategies to improve outcomes for marginalized groups within this population.",
  "authors": [
    {
      "affiliations": [
        "Centro Regional de Enfermedades Autoinmunes y Reumáticas, GO-CREAR, Rosario, Argentina"
      ],
      "name": "Rosana Quintana"
    },
    {
      "affiliations": [
        "Colombian Association of Rheumatology (ASOREUMA), Bogotá, Colombia",
        "Hospital Universitario San Ignacio, Bogotá, Colombia"
      ],
      "name": "Julián E Barahona-Correa"
    },
    {
      "affiliations": [
        "Hospital Universitario San Ignacio, Bogotá, Colombia"
      ],
      "name": "Santiago Bernal-Macías"
    },
    {
      "affiliations": [
        "San Ignacio University Hospital, Pontifical Javeriana University, Bogotá, Colombia"
      ],
      "name": "Daniel Fernández-Ávila"
    },
    {
      "affiliations": [
        "Hospital Universitario San Ignacio, Bogotá, Colombia"
      ],
      "name": "Óscar Muñoz"
    },
    {
      "affiliations": [
        "Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina"
      ],
      "name": "Lucia Hernandez"
    },
    {
      "affiliations": [
        "Hospital Italiano de Buenos Aires, Buenos Aires, Argentina"
      ],
      "name": "Erika Susana Palacios Santillan"
    },
    {
      "affiliations": [
        "Hospital Italiano de Córdoba, Córdoba, Argentina"
      ],
      "name": "Laura Maurelli"
    },
    {
      "affiliations": [
        "Servicio de Reumatología Hospital Córdoba y Sanatorio Allende, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina"
      ],
      "name": "Paula Alba"
    },
    {
      "affiliations": [
        "Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina"
      ],
      "name": "Verónica Saurit"
    },
    {
      "affiliations": [
        "Hospital San Martin de La Plata, La Plata, Argentina"
      ],
      "name": "Lucila García"
    },
    {
      "affiliations": [
        "Sanatorio Británico, Rosario, Argentina"
      ],
      "name": "María Emilia Sattler"
    },
    {
      "affiliations": [
        "Hospital Ángel C. Padilla, Tucumán, Argentina"
      ],
      "name": "Maria Constanza Bertolaccini"
    },
    {
      "affiliations": [
        "Hospital J.M Ramos Mejía, Buenos Aires, Argentina"
      ],
      "name": "Marina Laura Micelli"
    },
    {
      "affiliations": [
        "Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina"
      ],
      "name": "Graciela Noemí Gómez"
    },
    {
      "affiliations": [
        "CEMIC Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno, Buenos Aires, Argentina"
      ],
      "name": "Micaela A Cosatti"
    },
    {
      "affiliations": [
        "Hospital Señor del Milagro Salta, Salta, Argentina"
      ],
      "name": "Ana Carolina Ralle"
    },
    {
      "affiliations": [
        "Hospital General de Agudos Dr. Juan A. Fernández, Buenos Aires, Argentina"
      ],
      "name": "Joaquín Martinez Serventi"
    },
    {
      "affiliations": [
        "Hospital das Clinicas da Universidade Federal de Goias, Goiania, Brazil"
      ],
      "name": "Ana Carolina OS Montandon"
    },
    {
      "affiliations": [
        "Hospital de Clínicas de Porto Alegre, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil"
      ],
      "name": "Odirlei Andre Monticielo"
    },
    {
      "affiliations": [
        "Universidad Federal de Pernambuco, Recife, Brazil"
      ],
      "name": "Ángela Luzia Branco Pinto Duarte"
    },
    {
      "affiliations": [
        "Hospital Universitário Pedro Ernesto - Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil"
      ],
      "name": "Laíssa Cristina Alves Alvino"
    },
    {
      "affiliations": [
        "Faculdade de Medicina da Universidade de São Paulo, USP, São Paulo, Brazil"
      ],
      "name": "Eduardo F Borba"
    },
    {
      "affiliations": [
        "Faculdade de Medicina da Universidade de São Paulo, USP, São Paulo, Brazil"
      ],
      "name": "Eloisa Bonfa"
    },
    {
      "affiliations": [
        "Escola Paulista de Medicina/Universidade federal de São Paulo (EPM/Unifesp), São Paulo, Brazil"
      ],
      "name": "Edgard Torres Dos Reis-Neto"
    },
    {
      "affiliations": [
        "Hospital del Salvador Santiago de Chile, Santiago, Chile"
      ],
      "name": "Iris Guerra Herrera"
    },
    {
      "affiliations": [
        "Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile"
      ],
      "name": "Milena Mimica"
    },
    {
      "affiliations": [
        "Clínica de la Costa y Universidad Simón Bolívar Barranquilla, Barranquilla, Colombia"
      ],
      "name": "Gustavo Aroca Martínez"
    },
    {
      "affiliations": [
        "Clínica de la Costa y Universidad Simón Bolívar Barranquilla, Barranquilla, Colombia"
      ],
      "name": "Lorena Gómez Escorcia"
    },
    {
      "affiliations": [
        "Fundación Valle del Lili, Universidad Icesi, Cali, Colombia"
      ],
      "name": "Carlos A Cañas"
    },
    {
      "affiliations": [
        "Facultad de Medicina, Universidad Nacional de Colombia",
        "Hospital Universitario Fundación Santa Fe de Bogotá",
        "Hospital Universitario Nacional de Colombia, Bogotá, Colombia"
      ],
      "name": "Gerardo Quintana-Lopez"
    },
    {
      "affiliations": [
        "Centro de Referencia en Osteoporosis and Reumatología, Pontificia Universidad Javeriana de Cali, Cali, Colombia"
      ],
      "name": "Carlos Enrique Toro Gutiérrez"
    },
    {
      "affiliations": [
        "Universidad de Especialidades Espíritu Santo, Guayaquil, Ecuador"
      ],
      "name": "José Maximiliano Martínez Pérez"
    },
    {
      "affiliations": [
        "Hospital de Especialidades Dr. Antonio Fraga Mouret, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico"
      ],
      "name": "Reyna Elizabeth Sánchez-Briones"
    },
    {
      "affiliations": [
        "Hospital de Especialidades del Centro Médico Nacional SXXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico"
      ],
      "name": "Mario Pérez Cristóbal"
    },
    {
      "affiliations": [
        "Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico"
      ],
      "name": "Eduardo Martin-Nares"
    },
    {
      "affiliations": [
        "Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico"
      ],
      "name": "Yaneli Juárez-Vicuña"
    },
    {
      "affiliations": [
        "Centro de Estudios de Investigación Básica y Clínica, S.C., Guadalajara, Mexico"
      ],
      "name": "Ignacio García-Valladares"
    },
    {
      "affiliations": [
        "Facultad de Medicina de la Universidad Autónoma de San LUis Potosí y Hospital Central ‘Dr. Ignacio Morones Prieto, San Luis Potosi, Mexico"
      ],
      "name": "Rodrigo Ortiz Hernández"
    },
    {
      "affiliations": [
        "Hospital Universitario Dr. José Eleuterio Gonzalez, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México"
      ],
      "name": "Jorge A Esquivel Valerio"
    },
    {
      "affiliations": [
        "Facultad de Ciencias Medicas, Universidad Nacional de Asunción, San Lorenzo, Paraguay"
      ],
      "name": "Isabel Acosta Colman"
    },
    {
      "affiliations": [
        "Facultad de Ciencias Medicas, Universidad Nacional de Asunción, San Lorenzo, Paraguay"
      ],
      "name": "Astrid Paats"
    },
    {
      "affiliations": [
        "Hospital Nacional Edgardo Rebagliati Martins-EsSalud, Lima, Peru"
      ],
      "name": "Jorge Cieza Calderón"
    },
    {
      "affiliations": [
        "Grupo Peruano de Estudio de Enfermedades Autoinmunes Sistémicas, Universidad Científica del Sur, Lima, Peru",
        "Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Peru"
      ],
      "name": "Manuel F Ugarte-Gil"
    },
    {
      "affiliations": [
        "Hospital Nacional Cayetano Heredia, Universidad Peruana Cayetano Heredia, Lima, Peru"
      ],
      "name": "Armando Calvo Quiroz"
    },
    {
      "affiliations": [
        "Hospital Docente Padre Billini, Santo Domingo, Dominican Republic"
      ],
      "name": "Rodamin Alvarez"
    },
    {
      "affiliations": [
        "Hospital de Clínicas, Facultad de Medicina, UDELAR, Montevideo, Uruguay"
      ],
      "name": "Analía Cánepa"
    },
    {
      "affiliations": [
        "Médica Uruguaya, Facultad de Medicina-Universidad de la República, Montevideo, Uruguay"
      ],
      "name": "Carina Pizzarossa"
    },
    {
      "affiliations": [
        "Johnson & Johnson, Horsham, PA, USA"
      ],
      "name": "Federico Zazzetti"
    },
    {
      "affiliations": [
        "Johnson & Johnson, Spring House, PA, USA"
      ],
      "name": "Ashley Orillion"
    },
    {
      "affiliations": [
        "Rollins School of Public Health, Emory University, Atlanta, Georgia, USA"
      ],
      "name": "Cristina Drenkard"
    },
    {
      "affiliations": [
        "Centro Regional de Enfermedades Autoinmunes y Reumáticas, GO-CREAR, Rosario, Argentina",
        "Colombian Association of Rheumatology (ASOREUMA), Bogotá, Colombia",
        "Hospital Universitario San Ignacio, Bogotá, Colombia",
        "San Ignacio University Hospital, Pontifical Javeriana University, Bogotá, Colombia",
        "Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina",
        "Hospital Italiano de Buenos Aires, Buenos Aires, Argentina",
        "Hospital Italiano de Córdoba, Córdoba, Argentina",
        "Servicio de Reumatología Hospital Córdoba y Sanatorio Allende, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina",
        "Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina",
        "Hospital San Martin de La Plata, La Plata, Argentina",
        "Sanatorio Británico, Rosario, Argentina",
        "Hospital Ángel C. Padilla, Tucumán, Argentina",
        "Hospital J.M Ramos Mejía, Buenos Aires, Argentina",
        "Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina",
        "CEMIC Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno, Buenos Aires, Argentina",
        "Hospital Señor del Milagro Salta, Salta, Argentina",
        "Hospital General de Agudos Dr. Juan A. Fernández, Buenos Aires, Argentina",
        "Hospital das Clinicas da Universidade Federal de Goias, Goiania, Brazil",
        "Hospital de Clínicas de Porto Alegre, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, Brazil",
        "Universidad Federal de Pernambuco, Recife, Brazil",
        "Hospital Universitário Pedro Ernesto - Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil",
        "Faculdade de Medicina da Universidade de São Paulo, USP, São Paulo, Brazil",
        "Escola Paulista de Medicina/Universidade federal de São Paulo (EPM/Unifesp), São Paulo, Brazil",
        "Hospital del Salvador Santiago de Chile, Santiago, Chile",
        "Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile",
        "Clínica de la Costa y Universidad Simón Bolívar Barranquilla, Barranquilla, Colombia",
        "Fundación Valle del Lili, Universidad Icesi, Cali, Colombia",
        "Facultad de Medicina, Universidad Nacional de Colombia",
        "Hospital Universitario Fundación Santa Fe de Bogotá",
        "Hospital Universitario Nacional de Colombia, Bogotá, Colombia",
        "Centro de Referencia en Osteoporosis and Reumatología, Pontificia Universidad Javeriana de Cali, Cali, Colombia",
        "Universidad de Especialidades Espíritu Santo, Guayaquil, Ecuador",
        "Hospital de Especialidades Dr. Antonio Fraga Mouret, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico",
        "Hospital de Especialidades del Centro Médico Nacional SXXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico",
        "Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico",
        "Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico",
        "Centro de Estudios de Investigación Básica y Clínica, S.C., Guadalajara, Mexico",
        "Facultad de Medicina de la Universidad Autónoma de San LUis Potosí y Hospital Central ‘Dr. Ignacio Morones Prieto, San Luis Potosi, Mexico",
        "Hospital Universitario Dr. José Eleuterio Gonzalez, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México",
        "Facultad de Ciencias Medicas, Universidad Nacional de Asunción, San Lorenzo, Paraguay",
        "Hospital Nacional Edgardo Rebagliati Martins-EsSalud, Lima, Peru",
        "Grupo Peruano de Estudio de Enfermedades Autoinmunes Sistémicas, Universidad Científica del Sur, Lima, Peru",
        "Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Peru",
        "Hospital Nacional Cayetano Heredia, Universidad Peruana Cayetano Heredia, Lima, Peru",
        "Hospital Docente Padre Billini, Santo Domingo, Dominican Republic",
        "Hospital de Clínicas, Facultad de Medicina, UDELAR, Montevideo, Uruguay",
        "Médica Uruguaya, Facultad de Medicina-Universidad de la República, Montevideo, Uruguay",
        "Johnson & Johnson, Horsham, PA, USA",
        "Johnson & Johnson, Spring House, PA, USA",
        "Rollins School of Public Health, Emory University, Atlanta, Georgia, USA"
      ],
      "name": "On Behalf of Grupo Latino Americano De Estudio De Lupus (Gladel) Study Group of Panlar"
    }
  ],
  "title": "PT3:01 Feasibility of extrarenal systemic lupus erythematosus disease modification in GLADEL 2.0, a Latin American cohort",
  "uid": "1ad0c278-4aa0-51c5-8d3f-141a00f756e2"
}