{
  "abstract": "Objectives Pulmonary involvement is a frequent and significant feature of Systemic Lupus Erythematosus (SLE), although its clinical spectrum and outcomes remain poorly defined. This study aims to characterize the clinical features of pulmonary involvement in a multicentre Portuguese SLE cohort.Methods A multicentric, retrospective study was conducted across five Portuguese Rheumatology Departments, including adult SLE patients with at least one pulmonary manifestation (PM) attributable to SLE. Demographic and clinical data were collected, and a descriptive analysis was performed.Results A total of 51 SLE patients fulfilling the 2019 EULAR/ACR classification criteria with PMs were included. The majority were female (74.5%), with a mean age at SLE diagnosis of 37.0 ± 17.5 years and a mean age at first PM of 42.9 ± 17.6 years. The most common extra-pulmonary features were arthritis (74.5%), leukopenia/lymphopenia (52.9%) and acute cutaneous lupus (47.1%). Serositis was observed in 58.8% of patients. Most patients were non-smokers (71.4%), and chronic pulmonary diseases were infrequent (3.9–5.9%).PM occurred at the time of SLE diagnosis in 52.9% of patients, and after a mean interval of 12.9 ± 9.9 years in the remaining cases. The most frequent PMs were pleural involvement (56.9%) and interstitial lung disease (ILD) (21.6%), followed by pulmonary embolism (15.7%), pulmonary arterial hypertension (11.8%), and acute lupus pneumonitis (5.9%). Only one patient had shrinking lung syndrome, and 15.7% of patients presented more than one PM. At the time of PM, 44 of 46 patients (95.7) were symptomatic. The most common symptoms were pleuritic pain (54.5%), dyspnea (43.2%), fever (17.8%) and cough (15.9%). Median SLEDAI-2K and SLE-DAS reflected moderate disease activity. During the pulmonary episode, 40.8% of patients were hospitalized and 8.3% required oxygen therapy. There were five deaths overall, three due to infection, one related to SLE-associated PM, and one from cardiovascular disease.Abstract PO:09:225 Table 1Demographic, clinical, and pulmonary characteristics of patients with systemic lupus erythematosus and pulmonary involvement (n=51)Conclusions PMs in this SLE cohort represented significant morbidity. Although mortality directly attributable to PM was low, the clinical burden was substantial, with 95.7% of patients symptomatic and 40.8% hospitalized. Pleural disease was the most frequent manifestation, while ILD and pulmonary embolism highlight the need for a high index of suspicion to mitigate these complications.",
  "authors": [
    {
      "affiliations": [
        "Rheumatology Department, Unidade Local de Saúde da Região de Aveiro, Aveiro, Portugal",
        "Centro de Investigação em Reumatologia de Aveiro, Centro Académico Clínico Egas Moniz Health Alliance, Aveiro, Portugal"
      ],
      "name": "Carolina Vilafanha"
    },
    {
      "affiliations": [
        "Rheumatology Department, Unidade Local de Saúde da Região de Aveiro, Aveiro, Portugal",
        "Centro de Investigação em Reumatologia de Aveiro, Centro Académico Clínico Egas Moniz Health Alliance, Aveiro, Portugal"
      ],
      "name": "Pedro Miguel Teixeira"
    },
    {
      "affiliations": [
        "Rheumatology Department, Unidade Local de Saúde de São João, Porto, Portugal"
      ],
      "name": "Sara Amaro Lopes"
    },
    {
      "affiliations": [
        "Rheumatology Department, Unidade Local de Saúde Lisboa Ocidental, Lisboa, Portugal"
      ],
      "name": "Ana Catarina Moniz"
    },
    {
      "affiliations": [
        "Rheumatology Department, Unidade Local de Saúde de Gaia/Espinho, Vila Nova de Gaia, Portugal"
      ],
      "name": "Catarina Silva"
    },
    {
      "affiliations": [
        "Rheumatology Department, Unidade Local de Saúde da Lezíria, Santarém, Portugal"
      ],
      "name": "Filipa Farinha"
    },
    {
      "affiliations": [
        "Rheumatology Department, Unidade Local de Saúde da Região de Aveiro, Aveiro, Portugal",
        "Centro de Investigação em Reumatologia de Aveiro, Centro Académico Clínico Egas Moniz Health Alliance, Aveiro, Portugal",
        "EpiDoc Unit, Nova Medical School, NOVA University Lisbon, Lisboa, Portugal",
        "Comprehensive Health Research Center, NOVA University Lisbon, Lisboa, Portugal"
      ],
      "name": "Anabela Barcelos"
    },
    {
      "affiliations": [
        "Rheumatology Department, Unidade Local de Saúde da Região de Aveiro, Aveiro, Portugal",
        "Centro de Investigação em Reumatologia de Aveiro, Centro Académico Clínico Egas Moniz Health Alliance, Aveiro, Portugal",
        "EpiDoc Unit, Nova Medical School, NOVA University Lisbon, Lisboa, Portugal"
      ],
      "name": "Carolina Mazeda"
    },
    {
      "affiliations": [
        "Rheumatology Department, Unidade Local de Saúde da Região de Aveiro, Aveiro, Portugal",
        "Centro de Investigação em Reumatologia de Aveiro, Centro Académico Clínico Egas Moniz Health Alliance, Aveiro, Portugal"
      ],
      "name": "Gisela Eugénio"
    }
  ],
  "title": "PO:09:225 Characterization of pulmonary involvement in systemic lupus erythematosus: insights from a multicentre Portuguese cohort",
  "uid": "10b24571-f3e9-5a67-8457-823261a5ff33"
}