{
  "abstract": "Objective Negative self-perceptions of ageing are associated with decreased health-related quality of life (HRQoL) in older adults. We sought to characterise the association of self-perceptions of ageing, both positive and negative, with pain, depression and self-reported disability and frailty status in middle-aged and older adults with SLE.Methods We enrolled adults ≥50 years with validated SLE in a single-centre cross-sectional study. Sociodemographic characteristics and disease features were self-reported. Self-perceptions of ageing were assessed using awareness of age-related change (AARC). We assessed patient-reported outcomes, disability and frailty status using the Patient-Reported Outcomes Measurement Information System 29-Item Profile (PROMIS-29), Valued Life Activities and Fatigue, Resistance, Ambulation, Illness, Loss of Weight Scale. Associations between AARC gains (ie, positive self-perception of ageing) and losses (ie, negative self-perception of ageing) and pain interference, depression, disability and frailty status (frail ≥3/5 criteria) were assessed using linear or logistic regression and adjusted for age, race, ethnicity, and SLE disease activity and organ damage.Results Participants (n=80) were mostly female (95.0%) with mean age and SLE duration of 63.2 (SD=8.5) years and 23.1 (SD=14.5) years, respectively. Mean PROMIS-29 T-scores for pain interference and depression were 54.6 (SD=10.1) and 49.8 (SD=8.5), respectively; 29.9% were frail. After covariate adjustment, AARC losses, but not gains were significantly associated with pain interference (ß coefficient 0.94, 95% CI 0.33 to 1.54, p<0.01), depression (ß coefficient 0.67, 95% CI 0.04 to 1.30, p=0.04) and frailty (OR 2.09, 95% CI 1.30 to 3.37, p<0.01). After covariate adjustment, both AARC gains (ß coefficient −0.07, 95% CI −0.09 to –0.02, p<0.01) and losses (ß coefficient 0.08, 95% CI 0.03 to 0.12, p<0.01) were statistically significantly associated with disability.Conclusions Negative self-perception of ageing was independently associated with decreased HRQoL among middle-aged and older adults with SLE. Addressing negative self-perceptions of ageing may improve HRQoL in this population.",
  "authors": [
    {
      "affiliations": [
        "Division of Rheumatology, Hospital for Special Surgery, New York City, New York, USA",
        "Department of Medicine, Weill Cornell Medicine, New York City, New York, USA"
      ],
      "name": "Sarah B Lieber"
    },
    {
      "affiliations": [
        "Hospital for Special Surgery, New York City, New York, USA"
      ],
      "name": "Yvonne Shea"
    },
    {
      "affiliations": [
        "Hospital for Special Surgery, New York City, New York, USA"
      ],
      "name": "Sarah P Gottesman"
    },
    {
      "affiliations": [
        "Hospital for Special Surgery, New York City, New York, USA"
      ],
      "name": "Amaya Smole"
    },
    {
      "affiliations": [
        "Hospital for Special Surgery, New York City, New York, USA"
      ],
      "name": "Neha G Nagpal"
    },
    {
      "affiliations": [
        "Hospital for Special Surgery, New York City, New York, USA"
      ],
      "name": "Julia Nguyen"
    },
    {
      "affiliations": [
        "Hospital for Special Surgery, New York City, New York, USA"
      ],
      "name": "Ashley Chung"
    },
    {
      "affiliations": [
        "Division of Rheumatology, Hospital for Special Surgery, New York City, New York, USA"
      ],
      "name": "Dongmei Sun"
    },
    {
      "affiliations": [
        "Division of Rheumatology, Hospital for Special Surgery, New York City, New York, USA",
        "Department of Medicine, Weill Cornell Medicine, New York City, New York, USA",
        "Division of General Internal Medicine, Weill Cornell Medicine, New York City, New York, USA"
      ],
      "name": "Iris Navarro-Millán"
    },
    {
      "affiliations": [
        "Department of Medicine, Weill Cornell Medicine, New York City, New York, USA",
        "Division of Geriatrics and Palliative Medicine, Weill Cornell Medicine, New York City, New York, USA"
      ],
      "name": "M Carrington Reid"
    },
    {
      "affiliations": [
        "Division of Rheumatology, Hospital for Special Surgery, New York City, New York, USA",
        "Department of Medicine, Weill Cornell Medicine, New York City, New York, USA"
      ],
      "name": "Lisa A Mandl"
    }
  ],
  "title": "Perceptions of ageing among middle-aged and older adults with SLE: a single-centre cross-sectional study",
  "uid": "38615cd3-2fd4-5a1b-9970-eb8559cc4f27"
}