{
  "abstract": "Background The purpose of this study was to reveal the morphological changes of grey matter (GM) in women systemic lupus erythematosus (wSLE) patients with mild cognitive impairment (MCI) with normal conventional MRI.Methods The differences in brain morphological indicators among wSLE with MCI, wSLE without MCI and women healthy control (wHC) group were calculated and compared by voxel-based morphometry and surface-based morphometry. The GM volume (GMV), cortical thickness (CT), indicators of cortical complexity, including fractal dimension (FD), gyration index (GI), sulcus depth, the relationship between brain morphological indicators and clinical features, were analysed.Results In comparison to wSLE patients without MCI (n=36), wSLE with MCI (n=26) demonstrated a significant decrease in FD of the left lateral orbitofrontal gyrus. When compared with the wHC group (n=36), both wSLE patients with MCI and wSLE without MCI group exhibited a reduction in GMV in the medial of right superior frontal gyrus, a thinning of CT in the left paracentral and postcentral gyrus as well as in the right pars triangularis gyrus and superior frontal gyrus. Within the wSLE group, Mini-Mental State Examination scores were positively correlated with GMV in the middle of right superior frontal gyrus and with the FD of the left lateral orbitofrontal gyrus.Conclusion WSLE patients with MCI have brain morphological changes such as reduced GMV, thinning CT, reduced FD and increased GI. Cortical morphological changes may be involved in the pathological process of MCI in wSLE patients.",
  "authors": [
    {
      "affiliations": [
        "Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China"
      ],
      "name": "Minghuang Mo"
    },
    {
      "affiliations": [
        "Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China"
      ],
      "name": "Yifan Yang"
    },
    {
      "affiliations": [
        "Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China"
      ],
      "name": "Shuang Liu"
    },
    {
      "affiliations": [
        "Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China"
      ],
      "name": "Ru Bai"
    },
    {
      "affiliations": [
        "Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China"
      ],
      "name": "Shu Li"
    },
    {
      "affiliations": [
        "Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China"
      ],
      "name": "Ruotong Zhao"
    },
    {
      "affiliations": [
        "Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China"
      ],
      "name": "Xinyu Xu"
    },
    {
      "affiliations": [
        "Department of Psychiatry, Zhejiang University School of Medicine Affiliated Mental Health Centre & Hangzhou Seventh People’s Hospital, Hangzhou, Zhejiang, China"
      ],
      "name": "Yuqi Cheng"
    },
    {
      "affiliations": [
        "Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China"
      ],
      "name": "Jian Xu"
    }
  ],
  "title": "Cortical changes in women with systemic lupus erythematosus with mild cognitive impairment: a voxel-based morphometry and surface-based morphometry study",
  "uid": "2476b32b-d16c-5b9c-b7ef-7e0735fcda58"
}