{
  "abstract": "Introduction SSc is often complicated by ILD, which contributes significantly to morbidity and mortality. Krebs von den Lungen-6 (KL-6) has been identified as a potential biomarker for ILD severity. Nailfold videocapillaroscopy (NVC) is a non-invasive tool to detect microvascular changes in SSc, but its role in predicting ILD progression and outcomes requires further investigation. This study aimed to assess whether baseline NVC findings in SSc patients could predict pulmonary function decline and changes in serum biomarkers, inflammatory markers, disease activity indices (EUSTAR 2017, SCTC-DI), and other clinical parameters over a two-year follow-up periodMaterial and Methods This prospective longitudinal study included SSc patients diagnosed according to the 2013 ACR/EULAR criteria, stratified by the presence of ILD. Baseline assessments included NVC, chest high-resolution computed tomography (HRCT), pulmonary function tests (PFTs), and serum biomarker measurements (KL-6, IL-18, IL-18BP) using quantitative ELISA. The annualized rate of change in forced vital capacity (FVC) was calculated as a surrogate for ILD progression. Associations between baseline NVC patterns and longitudinal changes in %DLCO, %FVC, biomarkers, inflammatory markers, and disease indices were analyzed using correlation and multivariate regression modeling.Results 74 patients (27% male, mean age 57.5 ± 15 years) were included, with a mean disease duration of 7.67 ± 8 years. At baseline, 38% had ILD, which increased to 51% after two years, while the proportion with equal or more than 20% lung involvement on HRCT rose from 32% to 43%. Disorganization of capillary architecture at baseline predicted faster declines in %FVC (β = -0.75, p = 0.03) and %DLCO (β = -0.24, p = 0.03), as well as worsening modified Rodnan skin score (mRSS) (β = 0.23, p = 0.03) at two-year follow-up. A late NVC pattern was associated with worsened mRSS (β = 0.47, p = 0.004), larger increases in KL-6 (β = 0.18, p = 0.04), and a more rapid decline in %DLCO (β = -0.38, p = 0.04). A higher baseline SCTC-DI score predicted progression of semiquantitative fibrosis on HRCT (β = -0.32, p = 0.003) and elevated CRP levels (β = 0.38, p = 0.003) at two years.Conclusions Capillary disorganization and late NVC patterns at baseline predict faster declines in pulmonary function, increased serum KL-6 levels, and worsening skin fibrosis over two years in SSc patients. These findings suggest that NVC, in combination with biomarkers like KL-6, can serve as valuable tools for risk stratification and monitoring disease progression in SSc-ILD.Abstract P.084 Figure 1",
  "authors": [
    {
      "affiliations": [
        "University of Manchester, Manchester, United Kingdom"
      ],
      "name": "Cristiana Sieiro Santos"
    },
    {
      "affiliations": [
        "Complejo Asistencial Universitario de Leon, Leon, Spain"
      ],
      "name": "Jose Ordas Martinez"
    },
    {
      "affiliations": [
        "Complejo Asistencial Universitario de Leon, Leon, Spain"
      ],
      "name": "Miriam Retuerto Guerrero"
    },
    {
      "affiliations": [
        "Complejo Asistencial Universitario de Leon, Leon, Spain"
      ],
      "name": "Laura Sierra Herranz"
    },
    {
      "affiliations": [
        "Complejo Asistencial Universitario de Leon, Leon, Spain"
      ],
      "name": "Elena Bollo De Miguel"
    },
    {
      "affiliations": [
        "Complejo Asistencial Universitario de Leon, Leon, Spain"
      ],
      "name": "Elvira Diez Alvarez"
    }
  ],
  "title": "P.084 Baseline nailfold videocapillaroscopy and its prognostic value in pulmonary decline and disease progression in systemic sclerosis",
  "uid": "ca2fa9f6-a6af-5c56-8ad6-017af6eaed24"
}