{
  "abstract": "Introduction Systemic sclerosis (SSc) is a multiorgan disease affecting both the skin and internal organs. Internal organ involvement significantly influence outcome and it is associated with worse health related quality of life (HRQoL). Extent of skin involvement may be assessed by modified Rodnan Skin Score, but it does not capture patients perspective. Scleroderma Skin Patient-Reported Outcome (SSPRO) questionnaire was designed to assess the physiological effect of skin changes in SSc patients.Aims: To adapt and validate the SSPRO questionnaire into Hungarian, enabling the assessment of skin involvement and its impact on health-related quality of life in SSc patients.Material and Methods A total of 60 patients with SSc [female n=53, male n=7, mean age 58.1 ± 13.4 years, diffuse cutaneous SSc (dcSSc) n=31 (51.67%)] and 30 age- and sex-matched healthy controls were enrolled. The 18-item SSPRO questionnaire was translated and culturally adapted using the OMERACT filter.Results The questionnaire significantly differentiated between SSc patients and healthy controls (20,5 points [11–32] vs. 11 points [7–17], p < 0.007). No significant difference was found between lcSSc and dcSSc subgroups. A strong correlation was observed between SSPRO scores and reference questionnaires (Health Assessment Questionnaire Disability Index: rho=0,499, p< 0,001; Short Form Health Survey 36 Physical Component: rho=-0.570, p< 0.001; Dermatology Life Quality Index: rho=0,754, p< 0,001, respectively). During the assessment of reproducibility, a high intraclass correlation coefficient was found (Cronbach’s alpha=0,894, p<0,001). Principal component analysis grouped the items into three subdomains.Conclusions The adaptation and validation of the Scleroderma Skin Patient-Reported Outcome questionnaire into Hungarian was successful. The questionnaire is a quick, simple, and highly discriminative tool for assessing health-related quality of life.Support: Project TKP-2021-EGA-10 has been implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the TKP-2021-EGA funding scheme",
  "authors": [
    {
      "affiliations": [
        "University of Pécs, Medical Centre, Department of Rheumatology and Immunology, Pécs, Hungary"
      ],
      "name": "Panna Pytel"
    },
    {
      "affiliations": [
        "University of Pécs, Medical Centre, Department of Rheumatology and Immunology, Pécs, Hungary"
      ],
      "name": "Ágnes Ágoston-Szabó"
    },
    {
      "affiliations": [
        "University of Pécs, Medical Centre, Department of Rheumatology and Immunology, Pécs, Hungary"
      ],
      "name": "Attila Szabó"
    },
    {
      "affiliations": [
        "University of Pécs, Medical Centre, Department of Rheumatology and Immunology, Pécs, Hungary"
      ],
      "name": "Gábor Kumánovics"
    },
    {
      "affiliations": [
        "University of Pécs, Medical Centre, Department of Rheumatology and Immunology, Pécs, Hungary"
      ],
      "name": "Gabriella Nagy"
    }
  ],
  "title": "P.299 Adaptation and validation of the scleroderma skin patient-reported outcome questionnaire into Hungarian",
  "uid": "8681db91-1287-5e5d-8207-b76bb4af61c3"
}