{
  "abstract": "Introduction To investigate the demographic and clinical features of systemic sclerosis (SSc) patients with anti-U1RNP antibodies using the European Scleroderma Trials and Research (EUSTAR) database.Material and Methods SSc patients fulfilling SSc classification criteria with available data on anti-U1RNP antibodies were analyzed. Clinical characteristics were collected when the status of anti-U1RNP antibodies was first recorded and patients positive and negative for anti-U1RNP antibodies were compared by univariable analysis. Associations between anti-U1RNP status and organ involvement were assessed by multivariable logistic regression, adjusted for covariables. Multiple imputation was used to handle missing data.Results A total of 8391 patients were eligible for this analysis, among which 408 (4.9%) patients were positive for anti-U1RNP antibodies. By multivariable analysis, anti-U1RNP antibodies were confirmed to be independently associated with earlier disease onset (OR 0.96, 95% CI 0.95 to 0.97), synovitis (OR 1.82, 95% CI 1.20 to 2.77), pulmonary hypertension on echocardiography (OR 2.13, 95% CI 1.41 to 3.20), proteinuria (OR 2.25, 95% CI 1.29 to 3.93), lower mRSS (OR 0.95, 95% CI 0.93 to 0.98) and elevated ESR (OR 1.48, 95% CI 1.03 to 2.12). Besides, there was a negative association with white race (OR 0.25, 95% CI 0.17 to 0.37).Conclusions This is the largest cohort of SSc patients positive for anti-U1RNP antibodies reported so far. It defines a distinct clinical phenotype, with predilection for non-white race, younger disease onset, inflammation and articular, cardiopulmonary or renal involvement. The detection of anti-U1RNP antibodies in SSc patients might be helpful for risk stratification in clinical practice.",
  "authors": [
    {
      "affiliations": [
        "Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland",
        "Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China",
        "contributed equally"
      ],
      "name": "Wanlong Wu"
    },
    {
      "affiliations": [
        "Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland",
        "Department of Rheumatology, St Vincent’s Hospital Melbourne, Australia",
        "contributed equally"
      ],
      "name": "Madeleine Venables"
    },
    {
      "affiliations": [
        "Univ. Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000 Lille, France"
      ],
      "name": "Eric Hachulla"
    },
    {
      "affiliations": [
        "Rheumatology and Clinical Immunology Department, Spedali Civili, Brescia, Italy"
      ],
      "name": "Liala Moschetti"
    },
    {
      "affiliations": [
        "Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific Institute, Milan, Italy",
        "Vita-Salute San Raffaele University, Milan, Italy",
        "Inflammation Fibrosis and Ageing Initiative (INFLAGE), Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy"
      ],
      "name": "Marco Matucci-Cerinic"
    },
    {
      "affiliations": [
        "Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padova, Italy"
      ],
      "name": "Francesca Cozzi"
    },
    {
      "affiliations": [
        "Rheumatology A Department, Paris Descartes University, INSERM U1016, Sorbonne,Paris Cité, Cochin Hospital, Paris, France"
      ],
      "name": "Yannick Allanore"
    },
    {
      "affiliations": [
        "Department of Rheumatology, 12 de Octubre University Hospital, Madrid, Spain"
      ],
      "name": "Patricia E Carreira"
    },
    {
      "affiliations": [
        "‘Carol Davila’ University of Medicine and Pharmacy, Department of Rheumatology and Internal Medicine, ‘St. Maria’ Hospital, Bucharest, Romania"
      ],
      "name": "Andra Balanescu"
    },
    {
      "affiliations": [
        "Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"
      ],
      "name": "Ivan Castellví"
    },
    {
      "affiliations": [
        "Rheumatology Unit, AOU and University of Cagliari, Department of Medical Sciences and Public Health, Monserrato-CA, Italy"
      ],
      "name": "Alberto Cauli"
    },
    {
      "affiliations": [
        "Royal Free London and University College London Medical School, Centre for Rheumatology, London, United Kingdom"
      ],
      "name": "Christopher P Denton"
    },
    {
      "affiliations": [
        "Geneva University Hospitals, Hôpital Beau-Séjour, Division of Rheumatology, Geneva, Switzerland"
      ],
      "name": "Michele Iudici"
    },
    {
      "affiliations": [
        "Univ. Lille, Inserm, CHU Lille, Department of Internal Medicine and Clinical Immunology, Reference Center for Rare Autoimmune and Autoinflammatory diseases (CERAINOM), U1286 - INFINITE - Institute for Translational Research in Inflammation, Lille, France"
      ],
      "name": "Vincent Sobanski"
    },
    {
      "affiliations": [
        "JLU Giessen, Campus Kerckhoff, Department of Rheumatology and Clinical Immunology Center, Bad Neuheim, Germany"
      ],
      "name": "Ulf Mueller-Ladner"
    },
    {
      "affiliations": [
        "Grigore T Popa University of Medicine and Pharmacy Iasi, Rehabilitation Hospital, Department of Rheumatology, Romania"
      ],
      "name": "Elena Rezus"
    },
    {
      "affiliations": [
        "Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Italy"
      ],
      "name": "Simona Truglia"
    },
    {
      "affiliations": [
        "University Clinic Schleswig-Holstein Lübeck, Department of Rheumatology and Clinical Immunology, Lubeck, Germany"
      ],
      "name": "Gabriela Riemekasten"
    },
    {
      "affiliations": [
        "Institute for Treatment and Rehabilitation Niska Banja, Nis University School of Medicine, Nis, Niska Banja, Serbia"
      ],
      "name": "Bojana Stamenkovic"
    },
    {
      "affiliations": [
        "Padova University Hospital, Rheumatology Unit, Padova, Italy"
      ],
      "name": "Elisabetta Zanatta"
    },
    {
      "affiliations": [
        "Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"
      ],
      "name": "Shuang Ye"
    },
    {
      "affiliations": [
        "Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland"
      ],
      "name": "Suzana Jordan"
    },
    {
      "affiliations": [
        "Leeds Raynaud’s and Scleroderma Program, NIHR Biomedical Research Centre, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom"
      ],
      "name": "Francesco Del Galdo"
    },
    {
      "affiliations": [
        "Nippon Medical School Hospital, Tokyo, Japan"
      ],
      "name": "Masataka Kuwana"
    },
    {
      "affiliations": [
        "CHU de Bordeaux, Rheumatology department, Bordeaux, France"
      ],
      "name": "Marie-Elise Truchetet"
    },
    {
      "affiliations": [
        "Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland",
        "contributed equally"
      ],
      "name": "Rucsandra Dobrota"
    },
    {
      "affiliations": [
        "Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland",
        "contributed equally"
      ],
      "name": "Oliver Distler"
    },
    {
      "affiliations": [
        "Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland",
        "Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China",
        "Department of Rheumatology, St Vincent’s Hospital Melbourne, Australia",
        "Univ. Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000 Lille, France",
        "Rheumatology and Clinical Immunology Department, Spedali Civili, Brescia, Italy",
        "Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific Institute, Milan, Italy",
        "Vita-Salute San Raffaele University, Milan, Italy",
        "Inflammation Fibrosis and Ageing Initiative (INFLAGE), Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy",
        "Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padova, Italy",
        "Rheumatology A Department, Paris Descartes University, INSERM U1016, Sorbonne,Paris Cité, Cochin Hospital, Paris, France",
        "Department of Rheumatology, 12 de Octubre University Hospital, Madrid, Spain",
        "‘Carol Davila’ University of Medicine and Pharmacy, Department of Rheumatology and Internal Medicine, ‘St. Maria’ Hospital, Bucharest, Romania",
        "Hospital de la Santa Creu i Sant Pau, Barcelona, Spain",
        "Rheumatology Unit, AOU and University of Cagliari, Department of Medical Sciences and Public Health, Monserrato-CA, Italy",
        "Royal Free London and University College London Medical School, Centre for Rheumatology, London, United Kingdom",
        "Geneva University Hospitals, Hôpital Beau-Séjour, Division of Rheumatology, Geneva, Switzerland",
        "Univ. Lille, Inserm, CHU Lille, Department of Internal Medicine and Clinical Immunology, Reference Center for Rare Autoimmune and Autoinflammatory diseases (CERAINOM), U1286 - INFINITE - Institute for Translational Research in Inflammation, Lille, France",
        "JLU Giessen, Campus Kerckhoff, Department of Rheumatology and Clinical Immunology Center, Bad Neuheim, Germany",
        "Grigore T Popa University of Medicine and Pharmacy Iasi, Rehabilitation Hospital, Department of Rheumatology, Romania",
        "Department of Medical and Cardiovascular Sciences, Sapienza University of Rome, Italy",
        "University Clinic Schleswig-Holstein Lübeck, Department of Rheumatology and Clinical Immunology, Lubeck, Germany",
        "Institute for Treatment and Rehabilitation Niska Banja, Nis University School of Medicine, Nis, Niska Banja, Serbia",
        "Padova University Hospital, Rheumatology Unit, Padova, Italy",
        "Leeds Raynaud’s and Scleroderma Program, NIHR Biomedical Research Centre, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom",
        "Nippon Medical School Hospital, Tokyo, Japan",
        "CHU de Bordeaux, Rheumatology department, Bordeaux, France",
        "contributed equally"
      ],
      "name": "on behalf of the EUSTAR co-authors"
    }
  ],
  "title": "P.041 Demographic and clinical features of systemic sclerosis patients with anti-U1RNP antibodies: a European scleroderma trials and research (EUSTAR) analysis",
  "uid": "748cdee3-8c60-5ff1-ba31-ce754d7c9af9"
}