{
  "abstract": "Introduction Anti-SSA, anti-SSB, and anti-Ro52 antibodies (atbs) are commonly associated with sicca symptoms and overlap syndromes in systemic autoimmune diseases. In systemic sclerosis (SSc), their clinical relevance remains less well defined. While their association with dryness symptoms is expected, emerging evidence suggests these atbs, particularly anti-Ro52, may signal broader systemic involvement. This study aimed to explore the clinical and immunological profiles of SSc patients according to the presence of anti-SSA, anti-SSB, and anti-Ro52 atbs.Material and Methods We conducted a cross-sectional study of 187 SSc patients fulfilling the 2013 ACR/EULAR classification criteria, enrolled in a tertiary rheumatology center. Sociodemographic, clinical, serological, and disease-related features were compared between antibody-positive and -negative groups for anti-SSA, anti-SSB, and anti-Ro52. Associations were analyzed using Chi-square or Fisher’s exact test.Results The study population was predominantly female (85.6%), White European (98.4%), with a mean age of 52.5 ± 13.3 years. Most had limited cutaneous SSc (79.1%), and 12.3% had overlap syndromes. Raynaud’s phenomenon was almost universal (96.8%), and the most common autoantibodies were anticentromere (62.6%) and anti-Scl70 (21.9%).Anti-SSA was present in 9.1%, anti-SSB in 2.7%, and anti-Ro52 in 11.2% of patients. All three atbs were strongly associated with sicca symptoms, including dry mouth and dry eyes (p < 0.001). Anti-SSA and anti-SSB atbs were also associated with overlap syndromes (p < 0.001 and p = 0.007, respectively), particularly anti-SSA atbs, which were most often associated with Sjögren’s disease. Anti-Ro52 atbs showed a significant association with myositis (14.3% vs. 3.6%, p = 0.047), suggesting a link with muscular involvement in SSc. No associations were found between these atbs and digital ulcers, calcinosis, internal organ involvement, or most SSc-specific atbs.Conclusions These findings confirm that anti-SSA, anti-SSB, and anti-Ro52 atbs are markers of sicca features in SSc, but also highlight that anti-Ro52 atbs may indicate a broader disease expression, particularly myositis. The association with muscle involvement underscores the need for closer clinical monitoring of patients with anti-Ro52 atbs, even in the absence of classical overlap syndromes. While the small number of antibody-positive patients and missing Ro52 data limited statistical power, the results warrant further investigation. Larger, prospective cohorts with complete serological data are needed to validate these findings and clarify the prognostic implications of anti-Ro52 atbs in SSc.Abstract P.059 Table 1Sociodemographic, clinical, serological and disease-related features in patients with systemic sclerosis (SSc), according to the presence of anti-SSA, anti-SSB and anti-Ro52 antibodies",
  "authors": [
    {
      "affiliations": [
        "Rheumatology Department, Unidade Local de Saúde de São João, Porto, Portugal"
      ],
      "name": "Carlos Gomes"
    },
    {
      "affiliations": [
        "Rheumatology Department, Unidade Local de Saúde de São João, Porto, Portugal"
      ],
      "name": "Mariana Diz-Lopes"
    },
    {
      "affiliations": [
        "Rheumatology Department, Unidade Local de Saúde de São João, Porto, Portugal"
      ],
      "name": "Miguel Natal"
    },
    {
      "affiliations": [
        "Rheumatology Department, Unidade Local de Saúde de São João, Porto, Portugal"
      ],
      "name": "Bárbara Esteves"
    },
    {
      "affiliations": [
        "Rheumatology Department, Unidade Local de Saúde de São João, Porto, Portugal"
      ],
      "name": "Sara Lopes"
    },
    {
      "affiliations": [
        "Rheumatology Department, Unidade Local de Saúde de São João, Porto, Portugal"
      ],
      "name": "Ana Sá"
    },
    {
      "affiliations": [
        "Rheumatology Department, Unidade Local de Saúde de Viseu, Viseu, Portugal"
      ],
      "name": "Marina Oliveira"
    },
    {
      "affiliations": [
        "Rheumatology Department, Hospital Divino Espírito Santo, Ponta Delgada, Portugal"
      ],
      "name": "Mariana Sebastião"
    },
    {
      "affiliations": [
        "Rheumatology Department, Unidade Local de Saúde de São João, Porto, Portugal"
      ],
      "name": "Miguel Bernardes"
    },
    {
      "affiliations": [
        "Rheumatology Department, Unidade Local de Saúde de São João, Porto, Portugal"
      ],
      "name": "Raquel Ferreira"
    },
    {
      "affiliations": [
        "Rheumatology Department, Unidade Local de Saúde de São João, Porto, Portugal"
      ],
      "name": "Georgina Terroso"
    },
    {
      "affiliations": [
        "Rheumatology Department, Unidade Local de Saúde de São João, Porto, Portugal"
      ],
      "name": "Lúcia Costa"
    }
  ],
  "title": "P.059 Anti-SSA, anti-SSB and anti-RO52 in systemic sclerosis: more than just sicca",
  "uid": "70f17d47-c13c-5124-bf43-58f9dcf4fb39"
}