{
  "abstract": "Introduction Interstitial lung disease (ILD) significantly impairs prognosis and quality of life in systemic sclerosis Interstitial lung disease (ILD) significantly worsens prognosis and quality of life in systemic sclerosis (SSc). Identifying clinical, serological, and instrumental features associated with ILD may aid earlier detection and improved management. This study aimed to assess ILD-associated manifestations in SSc patients.Material and Methods This retrospective study included 41 SSc patients diagnosed per 2013 ACR/EULAR criteria, hospitalized during 2022–2024. ILD was confirmed by high-resolution computed tomography (HRCT). Assessments included spirometry (FVC), DLCO, echocardiography (E/A ratio, LVEF), modified Rodnan skin score (mRSS), 6-minute walk test (6MWT), nailfold videocapillaroscopy (NVC), and serological markers (anti-Scl-70, ACA). Statistical analyses used Fisher’s exact and Mann-Whitney U tests (p<0.05 significant).Results Among 41 patients (78.0% female, mean age 56 years), 63.4% (n=26) had ILD. Diffuse cutaneous SSc was more frequent in ILD patients (96.2% vs 26.7%, p<0.001), along with higher mRSS (22 vs 15, p=0.007) and anti-Scl-70 positivity (57 % vs 19 %, p=0.024). ACA was exclusive to the non-ILD group (46%, p<0.001).Pulmonary function was significantly lower in ILD patients: FVC (2223 ml vs 3476 ml, p=0.001; 75% vs 97%, p=0.010). DLCO tended to be reduced (51% vs 73%, p=0.093). Diastolic dysfunction (E/A <0.8) was more frequent in ILD patients (58% vs 20%, p=0.025), though LVEF remained preserved. 6MWT distances were significantly shorter in the ILD group (282 m vs 397 m, p<0.001).Among 28 patients undergoing NVC, early scleroderma pattern was absent in ILD patients, while active and late patterns predominated. Capillary loss (<7/mm2) was more frequent in ILD (77% vs 27%, p=0.033), as were digital ulcers (69% vs 33%, p=0.049).Conclusions SSc-associated ILD is strongly linked with diffuse subtype, extensive skin fibrosis, impaired lung function, diastolic dysfunction, microvascular damage, and reduced physical capacity. Recognizing these features may support earlier diagnosis and more effective patient management.",
  "authors": [
    {
      "affiliations": [
        "Department of Internal Medicine 2, Bogomolets National Medical University, Kyiv, Ukraine"
      ],
      "name": "Marta Dzhus"
    },
    {
      "affiliations": [
        "Department of Internal Medicine 2, Bogomolets National Medical University, Kyiv, Ukraine"
      ],
      "name": "Tatiana Karasevska"
    },
    {
      "affiliations": [
        "St. Michael Clinical Hospital, Kyiv, Ukraine"
      ],
      "name": "Ruslana Potoka"
    },
    {
      "affiliations": [
        "St. Michael Clinical Hospital, Kyiv, Ukraine"
      ],
      "name": "Hanna Novytska"
    },
    {
      "affiliations": [
        "St. Michael Clinical Hospital, Kyiv, Ukraine"
      ],
      "name": "Natiana Tkachuk"
    },
    {
      "affiliations": [
        "St. Michael Clinical Hospital, Kyiv, Ukraine"
      ],
      "name": "Kateryna Mulyk"
    }
  ],
  "title": "P.112 Interstitial lung disease in systemic sclerosis: clinical, serological, and instrumental associations in a Ukrainian patient cohort",
  "uid": "4913d27e-f565-526f-9190-52180a58545b"
}