{
  "abstract": "Introduction Gastroesophageal involvement, particularly reflux, has been identified as a risk factor for development and progression of interstitial lung disease (ILD) in adult systemic sclerosis However, this association has not yet been extensively studied in juvenile systemic sclerosis (jSSc). To further address this gap, the juvenile systemic scleroderma inception cohort(jSScIC) including 279 patients provides an opportunity to investigate the potential link between these two manifestations in the paediatric population.Material and Methods We analysed baseline clinical data from all patients enrolled in jSScIC till April 15 th, 2025 and compared the clinical characteristics of patients with and without GR.Results We reviewed data of 279 patients: 93 (33%) had reported to have gastroesophageal reflux (GR+). Patients with GR+ were more frequently evaluated by barium swallow (32% versus 18%, p=0.006) and endoscopy (22% versus 5%, p=0.041). Approximately 70% of the patients had diffuse cutaneous subset. The Median age at onset of first non-Raynaud presentation was around 11 years. Patients with GR+ had more nailfold capillary changes (91% versus 71%, p=0.001) and telangiectasia (49% versus 30%, p=0.002) compared to GR negative (GR-) patients. GR+ patients were more likely to have lung involvement than GR- patients with higher frequency had FVC< 80% (p=0.05), DLCO< 80% (p=0.001) and ILD as identified by high-resolution CT (p=0.004). The pulmonary function findings GR+ patients had more positive findings for ILD on high resolution CT of the lung as GR- patients (56% versus 37%, p=0.004). No significant differences were observed regarding autoantibody profile, cardiac, renal and musculoskeletal involvement between the groups.Conclusions GR+ had a significantly higher prevalence of ILD. Patients reported GR is correlating with an increased frequency of microvascular changes. This findings highlight the importance of assessing all patients for GR to enable timely management of reflux and potentially reduce occurrence/progression for ILD in jSSc. Further long-term studies are needed to prove our hypothesis and support targeted intervention strategies.Abstract P.336 Table 1Baseline characteristics of patients with and without gastroesophageal reflux in the jSScIC cohort, where we found clinically meaningful difference",
  "authors": [
    {
      "affiliations": [
        "Hamburg Center for Paediatric and Adolescent Rheumatology, Hamburg, Germany"
      ],
      "name": "Ivan Foeldvari"
    },
    {
      "affiliations": [
        "German Rheumatism Research Center, Berlin, Germany"
      ],
      "name": "Jens Klotsche"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Kathryn Torok"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Ozgur Kasapcopur"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Brian Feldman"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Flavio Sztajnbok"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Maria Teresa Terreri"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Jordi Anton"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Sindhu Johnson"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Raju Khubchandani"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Gülcan Özomay Baykal"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Dieneke Schonenberg-Meinema"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Eslam Al-Abadi"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Maria Katsicas,"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Sujata Sawhney"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Sima Abu Al-Saoud"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Simone Appenzeller"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Natalia Cabrera"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Stefanie Hajek"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Siri Opsahl Hetlevik"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Suzanne Li"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Edoardo Marrani"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Clare Pain"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Vanessa Smith"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Mikhail Kostik"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Hana Malcova"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Patricia Costa Reis"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Jorge M López Benítez"
    },
    {
      "affiliations": [
        "jSSc Collaborative Group, Hamburg, Germany"
      ],
      "name": "Mihaela Sparchez"
    },
    {
      "affiliations": [
        "Hamburg Center for Paediatric and Adolescent Rheumatology, Hamburg, Germany"
      ],
      "name": "Nicola Helmus"
    }
  ],
  "title": "P.336 Is gastroesophageal reflux a risk for interstitial lung disease in juvenile systemic sclerosis",
  "uid": "3442b550-c290-53cd-bbe4-a64e510f6f70"
}