{
  "abstract": "Introduction Interstitial lung disease (ILD) is the leading cause of mortality in systemic sclerosis (SSc). Half present with mild disease, of whom 25% progress over two years. Our aim was to explore the role of quantitative chest high-resolution computed tomography (HRCT) in predicting progression in mild SSc-ILD.Material and Methods We conducted a multicentric nested case-control study using data from the Canadian Scleroderma Research Group (CSRG) registry (2004-2020) and from the Centre hospitalier de l’Université de Montréal (CHUM, 2010-2020). Patients were included if they had a diagnosis of SSc and ILD on HRCT, a forced vital capacity of 80% predicted or above, available non-contrast HRCT images, and available pulmonary function test results at time of HRCT and within two years. Cases (progressors) were defined as those with clinically meaningful progression within two years, defined as at least 10% relative decline in FVC, or 5% to 10% relative decline in FVC combined with at least 15% relative decline in DLCO. Controls were matched 1:1 on age, sex and calendar year. Automated quantitative HRCT analysis was performed using the Computer-Aided Lung Informatics for Pathology Evaluation and Rating (CALIPER). Exploratory statistical analyses included Fisher’s exact tests and conditional logistic regression.Results In total, 38 patients from the CHUM cohort and 30 participants from the CSRG cohort met inclusion criteria. Mean age was 59.7 years, 35% had diffuse SSc, and median SSc duration was 7.2 years. CSRG and CHUM cohorts differed in proportion of women (93% vs 68%) and anti-topoisomerase I positivity (42% vs 8%). On quantitative HRCT analysis, in the CSRG cohort, progressors had higher %-involvement of ground glass opacities in the total lung (4.6% vs 0.7%, p= 0.021) and lower peripheral lung zones (20.5% vs 2.5%, p= 0.019). Conversely, in the CHUM cohort, progressors had numerically but not significantly higher %-involvement of total fibrosis (reticular infiltrates and honeycombing) in the total lung (5.8% vs 2.0%, p= 0.056) and lower peripheral lung zones (15.1% vs 4.9%, p= 0.077). Pulmonary vascular index was not significantly different between progressors and non-progressors.Conclusions A higher extent of ground glass opacities and fibrosis may be associated with a higher risk of lung disease progression in mild SSc-ILD. Larger and prospective studies would be helpful to determine the prognostic role of HRCT in mild SSc-ILD.",
  "authors": [
    {
      "affiliations": [
        "Centre hospitalier de l Universite de Montreal, Division of Rheumatology, Montreal, Canada"
      ],
      "name": "Sabrina Hoa"
    },
    {
      "affiliations": [
        "Centre hospitalier de l Universite de Montreal, Department of Medicine, Montreal, Canada"
      ],
      "name": "Marcelo Veiga Da Silva"
    },
    {
      "affiliations": [
        "Centre hospitalier de l Universite de Montreal, Division of Rheumatology, Montreal, Canada"
      ],
      "name": "Mathieu Rousseau"
    },
    {
      "affiliations": [
        "University Laval, Medicine, Montreal, Canada"
      ],
      "name": "Catherine Faucher"
    },
    {
      "affiliations": [
        "Centre hospitalier de l Universite de Montreal, Division of Rheumatology, Montreal, Canada"
      ],
      "name": "Yi Cheng Mu"
    },
    {
      "affiliations": [
        "Centre hospitalier de l Universite de Montreal, Department of Medicine, Montreal, Canada"
      ],
      "name": "Jean Chalaoui"
    },
    {
      "affiliations": [
        "Centre hospitalier de l Universite de Montreal, Department of Medicine, Montreal, Canada"
      ],
      "name": "Patrick Bourgouin"
    },
    {
      "affiliations": [
        "Centre hospitalier de l Universite de Montreal, Division of Rheumatology, Montreal, Canada"
      ],
      "name": "Raphael Hurtubise"
    },
    {
      "affiliations": [
        "University of Calgary, Division of Rheumatology, Calgary, Canada"
      ],
      "name": "Maggie Larche"
    },
    {
      "affiliations": [
        "University of Calgary, Division of Rheumatology, Calgary, Canada"
      ],
      "name": "May Choi"
    },
    {
      "affiliations": [
        "University of Alberta, Division of Rheumatology, Edmonton, Canada"
      ],
      "name": "Mohammed Osman"
    },
    {
      "affiliations": [
        "University of Western Ontario, Division of Rheumatology, London, Canada"
      ],
      "name": "Janet Pope"
    },
    {
      "affiliations": [
        "Southlake Regional Health Centre, Newmarket, Canada"
      ],
      "name": "Carter Thorne"
    },
    {
      "affiliations": [
        "Centre hospitalier de l Universite de Montreal, Department of Medicine, Montreal, Canada"
      ],
      "name": "Carl Chartrand-Lefebvre"
    },
    {
      "affiliations": [
        "McGill University, Montreal, Canada"
      ],
      "name": "Murray Baron"
    },
    {
      "affiliations": [
        "on behalf of the Canadian Scleroderma Research Group, Canada, Canada"
      ],
      "name": "Canadian Scleroderma Research Group"
    }
  ],
  "title": "P.109 Prognostic value of quantitative chest computed tomography for predicting progression of mild interstitial lung disease in systemic sclerosis: a multicentric nested case-control study",
  "uid": "242deb7c-5709-579a-8bbb-030a86088124"
}