{
  "abstract": "The Scleroderma Clinical Trials Consortium (SCTC) is committed to advancing the understanding and treatment of systemic sclerosis (SSc). This review focuses on the development and validation of various outcome instruments by the SCTC, which are crucial for evaluating the effectiveness of interventions in clinical trials and observational studies. Key instruments discussed include the Assessment of Systemic Sclerosis-Associated RAynaud’s Phenomenon Questionnaire, the SCTC Radiologic Scoring System for calcinosis, the Mawdsley Questionnaire for calcinosis, the University of California Los Angeles SCTC Gastrointestinal Tract Instrument (GIT) 2.0, the SCTC Activity Index and the SCTC Damage Index. Additionally, the SCTC and World Scleroderma Foundation (WSF) Skin Scoring Certification is highlighted as an important resource for researchers. Each instrument’s purpose, description and validation process are examined, underscoring their pivotal role in advancing SSc research and improving patient outcomes.",
  "authors": [
    {
      "affiliations": [
        "Rheumatology and Clinical Immunology, Pontificia Universidad Catolica de Chile, Santiago de Chile, Santiago Metropolitan Region, Chile",
        "Red de Salud UC Christus, Santiago, Santiago Metropolitan Region, Chile"
      ],
      "name": "Antonia Valenzuela"
    },
    {
      "affiliations": [
        "Stanford University School of Medicine, Stanford, California, USA",
        "VA Palo Alto Health Care System, Palo Alto, California, USA"
      ],
      "name": "Lorinda Chung"
    },
    {
      "affiliations": [
        "Department of Rheumatology, NHS North Bristol NHS Trust, Bristol, UK",
        "Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, Bristol, UK"
      ],
      "name": "John D Pauling"
    },
    {
      "affiliations": [
        "Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA"
      ],
      "name": "Robyn Domsic"
    },
    {
      "affiliations": [
        "Medicine, New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, Louisiana, USA",
        "University Medical Center—Comprehensive Pulmonary Hypertension Center and Interstitiatial Lung Disease Clinic Programs, New Orleans, Louisiana, USA"
      ],
      "name": "Lesley Saketkoo"
    },
    {
      "affiliations": [
        "Patient Research Partner, London, UK",
        "Scleroderma & Raynaud UK (SRUK), London, UK"
      ],
      "name": "Kim Fligelstone"
    },
    {
      "affiliations": [
        "Birmingham City University School of Health Sciences, Birmingham, UK",
        "University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"
      ],
      "name": "Anne-Marie Russell"
    },
    {
      "affiliations": [
        "University of Michigan, Ann Arbor, Michigan, USA"
      ],
      "name": "Dinesh Khanna"
    },
    {
      "affiliations": [
        "Division of Rheumatology and Immunology, Vanderbilt University, Nashville, Tennessee, USA"
      ],
      "name": "Tracy Frech"
    },
    {
      "affiliations": [
        "University of Melbourne VCCC, Parkville, Victoria, Australia"
      ],
      "name": "Laura Ross"
    },
    {
      "affiliations": [
        "The University of Sydney School of Public Health, Sydney, New South Wales, Australia",
        "Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia"
      ],
      "name": "Mandana Nikpour"
    },
    {
      "affiliations": [
        "Division of Medicine, University College London Medical School, London, UK"
      ],
      "name": "Christopher Denton"
    },
    {
      "affiliations": [
        "Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada"
      ],
      "name": "Murray Baron"
    }
  ],
  "title": "Scleroderma Clinical Trials Consortium (SCTC) outcome instruments for evaluation of systemic sclerosis",
  "uid": "d7ed2d9d-3251-55f9-a239-0633fdc9f57e"
}