{
  "abstract": "Amyloid-related imaging abnormalities (ARIA) represent a spectrum of MRI-detectable complications linked to anti-amyloid monoclonal antibody therapies for Alzheimer’s disease (AD). 1 2 The pathophysiology arises from the interplay between amyloid-β (Aβ) clearance and vascular inflammation (figure 1).1 These antibodies mediate parenchymal amyloid clearance with coincident destabilisation of cerebrovascular integrity, particularly in patients with pre-existing cerebral amyloid angiopathy (CAA). This process mobilises Aβ fragments that overwhelm perivascular drainage, triggering an inflammatory cascade and blood-brain barrier (BBB) disruption. The resultant manifestations are vasogenic oedema/sulcal effusion (ARIA-E) and microhaemorrhages/superficial siderosis (ARIA-H). Their frequent co-occurrence underscores a shared mechanism of Aβ-mediated vascular injury.3",
  "authors": [
    {
      "affiliations": [
        "Department of Radiology, West China Hospital of Sichuan University, Chengdu, China"
      ],
      "name": "Na Hu"
    },
    {
      "affiliations": [
        "Department of Radiology, West China Hospital of Sichuan University, Chengdu, China"
      ],
      "name": "Xiyue Yang"
    },
    {
      "affiliations": [
        "Department of Radiology, Peking Union Medical College Hospital, Beijing, China"
      ],
      "name": "Feng Feng"
    },
    {
      "affiliations": [
        "Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Zhongshan Road, Nanjing, China"
      ],
      "name": "Bing Zhang"
    },
    {
      "affiliations": [
        "Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China"
      ],
      "name": "Yaou Liu"
    },
    {
      "affiliations": [
        "Department of Neurology, West China Hospital of Sichuan University, Chengdu, China"
      ],
      "name": "Hui Gao"
    },
    {
      "affiliations": [
        "Department of Neurology, West China Hospital of Sichuan University, Chengdu, China"
      ],
      "name": "Qin Chen"
    },
    {
      "affiliations": [
        "Department of Neurology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China"
      ],
      "name": "Cun-Jin Zhang"
    },
    {
      "affiliations": [
        "Department of Neurology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology and Institute of Neuroscience, Fujian Medical University, Fuzhou, China"
      ],
      "name": "Xiaochun Chen"
    },
    {
      "affiliations": [
        "Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China"
      ],
      "name": "Fuhua Yan"
    },
    {
      "affiliations": [
        "Department of Radiology, West China Hospital of Sichuan University, Chengdu, China",
        "CIMC - Centre d'Imagerie Médicale de Cornavin, Geneva, Switzerland",
        "Faculty of Medicine, University of Geneva, Geneva, Switzerland"
      ],
      "name": "Sven Haller"
    },
    {
      "affiliations": [
        "Department of Radiology, West China Hospital of Sichuan University, Chengdu, China"
      ],
      "name": "Su Lui"
    }
  ],
  "title": "Amyloid-related imaging abnormalities (ARIA) in Alzheimer’s immunotherapy: a framework and challenges for global surveillance strategies",
  "uid": "e3393821-5ea8-5036-99d9-fc72398246c1"
}