{
  "abstract": "Sarcoidosis and inclusion body myositis are idiopathic inflammatory diseases which are rarely reported to coexist. We report a series of two patients with these conditions and describe their clinical and pathophysiological findings.Case 1 is a 65-year-old male who had insidious onset proximal muscle weakness on a background of sarcoidosis. Neurophysiology showed involvement of the tibialis anterior, quadriceps and long finger extensors. Muscle biopsy revealed non-caseating granulomas consistent with sarcoid myopathy as well as vacuoles with infiltrates as seen in inclusion body myositis.Case 2 is a 64-year-old female who presented with proximal muscle weakness along with swallowing difficulty with past history of sarcoidosis. Clinically there was weakness of small muscle of hands and quadriceps. Electrophysiology and muscle biopsy confirmed inclusion body myositis along with some non-caseating granuloma suggestive of combined pathology.As reported in literature, these cases may represent either a dual pathology or more likely development of inclusion body myositis in sarcoid myopathy. Treatment strategies are conflicting; unlike sarcoidosis, inclusion body myositis does not respond to treatment with steroids and immunosuppressants. These cases highlight the importance of reviewing patients clinically and pathologically for possible coexisting disease as the treatment strategy would need to be tailored accordingly.drzaibwazir@gmail.com",
  "authors": [
    {
      "affiliations": [
        "The Walton Centre"
      ],
      "name": "Nissa Zebun"
    },
    {
      "affiliations": [
        "The Walton Centre"
      ],
      "name": "Dougan Charlotte"
    },
    {
      "affiliations": [
        "The Walton Centre"
      ],
      "name": "Pal Piyali"
    },
    {
      "affiliations": [
        "The Walton Centre"
      ],
      "name": "Williamson John"
    }
  ],
  "title": "77 Sarcoid myopathy and inclusion body myositis – a coexistence or continuum of a spectrum",
  "uid": "f4fe3cae-fee9-5d91-a549-b196fd84f9d3"
}