{
  "abstract": "Background Opsoclonus-myoclonus-ataxia syndrome (OMAS) is a rare immune mediated neurological disorder characterized by opsoclonus (rapid, oscillatory eye movement), myoclonic jerks mostly in the face and limbs, cerebellar ataxia, tremors, and encephalopathy. OMAS is rare in adults and exceedingly rarer in pregnancy, as only a few cases in pregnancy have been reported. To the best of our knowledge, this is the fifth presented case of OMAS with a severe clinical course and complete reversibility of neurological symptoms in a pregnant woman.Clinical Course and Management We report and discuss a challenging case of OMAS which presented at 36 th week of pregnancy in a 38 years old lady. Despite extensive infectious and malignancy evaluation, an underlying etiology was not readily apparent thus we treated her with high dose intravenous steroids and intravenous immunoglobulin (IVIG) for presumed idiopathic autoimmune OMAS. She showed significant clinical improvement after IVIG and childbirth through LUCS. Her workup identified normal MRI brain, and CSF positive for oligoclonal bands. At 6 months’ follow up she showed significant clinical improvement without any objective evidence of abnormal movement or opsoclonus.Conclusion An autoimmune response is usually thought to occur in OMAS by molecular mimicry with neuronal cell surface antigens in association with infections. Since a preceding infection was absent in this case, we propose that the immune response here was initiated due to immunological changes in pregnancy.sanjida.chowdhury@nhs.net",
  "authors": [
    {
      "affiliations": [
        "Nottingham Hospitals NHS Trust"
      ],
      "name": "Chowdhury Sanjida"
    },
    {
      "affiliations": [
        "Royal Derby Hospital"
      ],
      "name": "Vaithianathar Lalitha"
    }
  ],
  "title": "89 Opsoclonus-myoclonus-ataxia syndrome in pregnancy with severe clinical course and complete recovery: a case report",
  "uid": "ebcb410d-4a19-5638-81d0-1a16f1710242"
}