{
  "abstract": "A 54-year-old male presented with initial symptoms suggestive of a transient ischemic attack (TIA), including tingling and word-finding difficulty, which was initially attributed to a migraine. Over the next few months, he developed right thigh pain, a change in gait, and progressive weakness. He subsequently experienced paraesthesia, coldness, and numbness in both feet, leading to ”furniture walking” and a sensation of increasing heaviness in his legs. Peripheral oedema also developed and progressively worsened. CT imaging revealed splenomegaly, and neurological examination showed areflexia, reduced lower limb power, and inability to perform tandem walking. Laboratory results revealed a significantly elevated lambda light chain (116.3 mg/L) and an IgG lambda paraprotein. Bone marrow aspirate indicated monoclonal gammopathy of undetermined significance (MGUS). The diagnosis was clinched with an MRI of the right femur which revealed a plasmacytoma, and further investigations confirmed the diagnosis of POEMS syndrome. The patient later slipped and suffered a neck of femur fracture secondary to the plasmacytoma. This case highlights the complexity of diagnosing POEMS syndrome, which can present with diverse symptoms, including peripheral neuropathy, oedema, and plasmacytoma, and emphasizes the importance of a comprehensive diagnostic approach.lindalei93@gmail.com",
  "authors": [
    {
      "affiliations": [
        "Royal Free Hospital",
        ", Royal Free Hospital"
      ],
      "name": "Lei Linda"
    },
    {
      "affiliations": [
        "Royal Free Hospital",
        ", Royal Free Hospital"
      ],
      "name": "Batla Amit"
    }
  ],
  "title": "85 Pain, peripheral oedema and numbness: unveiling plasmacytoma in POEMS syndrome",
  "uid": "dfdb6c0d-f6ef-51ea-b11d-aa6c374793fe"
}