{
  "abstract": "Introduction Following acquired brain injury (ABI), patients are often commenced on anti-seizure medications (ASM). There are risks associated with indefinite ASM use but no evidence around how they should be safely weaned off in this population.Methods A retrospective cohort study of post-ABI patients transferred to inpatient neurorehabilitation on ASM (excluding those with pre-ABI epilepsy or on ASM for other indications) evaluating the relationship between ABI diagnostic category, prior neurosurgical intervention, time from ABI to first seizure and the development of emergent seizures in those where weaning had been attempted.Results Of the 320 patients with ABI admitted on ASM, weaning was attempted in114 patients. Emergent seizures developed in 17(12.6%). Previous neurosurgery(Χ 2=2.8, p=.09) or seizures post-ABI(Χ2=1.9, p=.17) did not predict weaning failure. The mean time between ABI and first seizure was 114 days in those where weaning failed and 28 days where later emergent seizures did not occur. There were fewer emergent seizures for ABI due to neurovascular(6%) causes than trauma(23%) and anoxia(28%).Conclusion Our study highlighted potential predictors of successful weaning of post-ABI ASM. Larger scale multi-site prospective data collection on weaning processes and outcomes would inform the development of a clinically effective weaning protocol in this cohort.mchan@rhn.org.uk",
  "authors": [
    {
      "affiliations": [
        "Royal Hospital for Neuro-Disability, London, UK"
      ],
      "name": "Chan Marcus"
    },
    {
      "affiliations": [
        "Royal Hospital for Neuro-Disability, London, UK"
      ],
      "name": "O’Mahony Catherine"
    },
    {
      "affiliations": [
        "Royal Hospital for Neuro-Disability, London, UK"
      ],
      "name": "Bradley Lloyd"
    }
  ],
  "title": "60 Predicting the emergence of seizures in acquired brain injury patients weaning off anti-seizure medication",
  "uid": "dd0853f8-a4b4-52e2-af9e-6b18df853382"
}