{
  "abstract": "Background The significant mortality risk of epilepsy is partly driven by status epilepticus (SE). Pharmaceutical rescue therapies, such as buccal midazolam (BM), aim to terminate SE. This survey evaluates UK-based healthcare professionals’ clinical practice and experience in prescribing community-based rescue therapies.Methods A 21 item questionnaire composed of Likert-style and free-text questions was distributed through a non-discriminative snow-balling methodology to Epilepsy Specialist Nurses’ Association (ESNA) and the British International League Against Epilepsy (ILAE) members. Quantitative analysis used Chi-squared, Fishers’ exact and Mann-Whitney tests. Qualitative data were analysed through NVivo 14 software, following Braun and Clarke methodology.Results 86 participants (nurses n=64, doctors n=21) responded, indicating guideline-concordant use of emergency management plans and BM as a first-choice therapy for tonic-clonic seizures in SE. However, significant differences (P < 0.05) emerged between doctors and nurses in prescribing practices, including maximum dose, withdrawal strategies and use in multimorbid patients. Qualitative analysis identified eight themes, including concerns regarding BM overuse, misuse and abuse by patients and carers.Conclusion This study highlights the need for evidence-based guidelines on BM use in multimorbid patients and deprescribing strategies. Furthermore, robust safeguarding protocols are needed to regulate BM’s misuse and abuse potential, supported by oncoming community-based technologies.mcaebride@outlook.com",
  "authors": [
    {
      "affiliations": [
        "University of Exeter Medical School"
      ],
      "name": "McBride Audrey"
    },
    {
      "affiliations": [
        "Peninsula Medical School, University of Plymouth, Truro, UK",
        "Swansea Bay University Health Board, Neath Port Talbot, UK",
        "University of South Wales, Newport, UK"
      ],
      "name": "Watkins Lance"
    },
    {
      "affiliations": [
        "University of Leicester, Leicester, UK",
        "Tizard Centre, University of Kent, Canterbury, UK"
      ],
      "name": "Tromans Samuel"
    },
    {
      "affiliations": [
        "Adult Learning Disability Service, Leicestershire Partnership NHS Trust, UK"
      ],
      "name": "Triantafyllopoulou Paraskevi"
    },
    {
      "affiliations": [
        "Statsconsultancy Ltd, Bucks, UK"
      ],
      "name": "Basset Paul"
    },
    {
      "affiliations": [
        "The Royal Wolverhampton NHS Trust, Wolverhampton, UK",
        "Epilepsy Specialist Nurses Association, UK"
      ],
      "name": "Tittensor Phil"
    },
    {
      "affiliations": [
        "Epilepsy Specialist Nurses Association, UK"
      ],
      "name": "Jory Caryn"
    },
    {
      "affiliations": [
        "Peninsula Medical School, University of Plymouth, Truro, UK",
        "The Royal Wolverhampton NHS Trust, Wolverhampton, UK"
      ],
      "name": "Shankar Rohit"
    }
  ],
  "title": "235 Current clinical practice in prescribing buccal midazolam for status epilepticus termination in the United Kingdom",
  "uid": "af657bbd-3b11-53cd-bb26-1ec592e049ab"
}