{
  "abstract": "Objective, responsive biomarkers are required to assess disease progression and inform clinical trials in the inflammatory neuropathies. Peripherin and periaxin, biomarkers of peripheral axonal damage and demyelination, respectively, have recently been validated in Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Here, we evaluate their potential clinical utility in chronic immune-mediated neuropathies, alongside neurofilament light chain (NfL) and existing outcome measures.Clinical data were retrospectively analysed.Peripherin and NfL were measured in samples from patients with multifocal motor neuropathy (MMN, n=11), POEMS syndrome (n=14), anti-MAG neuropathy (n=14), multiple sclerosis (MS, n=20), and healthy controls (HC, n=20).Peripherin levels were higher in MMN and POEMS compared to HC (p = 0.01). NfL was higher in MMN vs HC (p = 0.0053), and the peripherin/NfL ratio was higher in MMN compared to MS (p = 0.029). In three POEMS patients with longitudinal data, peripherin closely mirrored VEGF levels over time.Fluid biomarkers show potential in the inflammatory neuropathies. Work is underway to measure peripherin, periaxin, and NfL in larger, deeply phenotyped patient cohorts. We will compare MMN levels to lower motor neuron-predominant motor neurone disease, and evaluate correlation with paraprotein levels, antibody titres (GM1, GQ1b, MAG), VEGF, and existing outcome measures.roberto.bellanti@nhs.net",
  "authors": [
    {
      "affiliations": [
        "Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK",
        "Department of Neuromuscular Diseases, Queen Square Institute of Neurology, UCL, London, UK",
        "Centre for Neuromuscular Diseases, NHNN, Queen Square, London, UK"
      ],
      "name": "Bellanti Roberto"
    },
    {
      "affiliations": [
        "Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK"
      ],
      "name": "Lester David G"
    },
    {
      "affiliations": [
        "Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK"
      ],
      "name": "Dubuisson Nicolas"
    },
    {
      "affiliations": [
        "Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK"
      ],
      "name": "Turner Martin R"
    },
    {
      "affiliations": [
        "Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK"
      ],
      "name": "Thompson Alexander G"
    },
    {
      "affiliations": [
        "Department of Neuromuscular Diseases, Queen Square Institute of Neurology, UCL, London, UK",
        "Neuroimmunology and CSF Laboratory, National Hospital for Neurology and Neurosurgery, London, UK",
        "Centre for Neuromuscular Diseases, NHNN, Queen Square, London, UK"
      ],
      "name": "Lunn Michael P"
    },
    {
      "affiliations": [
        "Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK"
      ],
      "name": "Rinaldi Simon"
    }
  ],
  "title": "160 Fluid biomarkers in chronic inflammatory neuropathies: comparative analysis and evaluation of diagnostic utility",
  "uid": "6ac92c4f-dc05-5159-8128-85d168c97443"
}